A5060171549- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Fatty Acid Research and Health
- Nutrition, Health and Food Behavior
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipoproteins and Cardiovascular Health
- Nutrition, Genetics, and Disease
- Metabolism, Diabetes, and Cancer
- Health and Wellbeing Research
- Phytochemicals and Antioxidant Activities
- Blood properties and coagulation
- Regulation of Appetite and Obesity
- Clinical Nutrition and Gastroenterology
Dong-A University
2016-2025
Pohang University of Science and Technology
2013
Yonsei University
2003-2012
Yonsei University Health System
2011
Institut Pasteur
2009-2010
DNA Link (South Korea)
2004-2005
Jean Mayer Human Nutrition Research Center on Aging
2004-2005
Tufts University
2004-2005
Obesity is currently epidemic in many countries worldwide and strongly related to diabetes cardiovascular disease. This study investigated the differences metabolomic profiling between overweight/obese normal-weight men. Overweight/obese (n=30) age-matched, men were included. Anthropometric parameters, conventional metabolites, biomarkers measured. Metabolomic was analyzed with UPLC-Q-TOF MS. showed higher levels of HOMA-IR, triglycerides, total cholesterol, LDL-cholesterol, lower...
To determine whether circulating metabolic intermediates are associated with inflammation, oxidative stress and arterial stiffness in men newly diagnosed type 2 diabetes investigate the that may predict risk of developing diabetes.Men (n = 26) age- body mass index-matched nondiabetic 27) were included. We measured inflammatory markers by brachial-ankle pulse wave velocity (ba-PWV). Metabolomic profiling was analysed ultra performance liquid chromatography quadrupole time-of-flight...
Our objective was to evaluate whether isocaloric replacement of refined rice with whole grains and other plant products as a form powder reduces coronary artery disease (CAD) risk factors, such insulin demand lipid peroxidation in CAD patients. Seventy-six male patients were randomly assigned either group ingesting whole-grain meal daily or control for 16 weeks. In the group, serum concentrations glucose decreased by 24% 14%, respectively, without altering body weight energy intake, whereas...
Abstract Introduction Decreased expression of human leukocyte antigen class II (HLA-DR) on monocytes is a hallmark altered immune status in patients with systemic inflammatory response syndrome (SIRS). So far, the analyses were mainly performed without taking into account subpopulations. Methods We studied this modification CD14 HIGH and LOW 20 SIRS undergoing abdominal aortic surgery (AAS), carotid artery (CAS), 9 healthy controls, we investigated mediators intracellular molecules that may...
In vitro and animal studies have demonstrated that Chlorella is a potent biological response modifier on immunity. However, there were no direct evidences for the effect of supplementation immune/inflammation in healthy humans. This study was designed an 8-week randomized, double-blinded, placebo-controlled trial: 5g (n=23) or Placebo (n=28) as form tablets. Mainly, cytotoxic activities Natural killer (NK) cells serum concentrations interferon-γ, interleukin-1β interleukin-12 measured. After...
Alzheimer disease (AD) is a neurodegenerative disorder characterized by excessive accumulation of amyloid-beta peptide (Aβ) and progressive loss neurons. Therefore, the inhibition Aβ-induced neurotoxicity potential therapeutic approach for treatment AD. Ecklonia cava an edible brown seaweed, which has been recognized as rich source bioactive derivatives, mainly phlorotannins. In this study, phlorotannins including eckol, dieckol, 8,8′-bieckol were used neuroprotective candidates their...
This study aimed to identify the optimal features of gait parameters predict fall risk level in older adults. The included 746 adults (age: 63-89 years). Gait tests (20 m walkway) speed modification (slower, preferred, and faster-walking) while wearing inertial measurement unit sensors embedded shoe-type data loggers on both outsoles. A metric was defined classify risks, determined based a set questions determining history falls fear falls. extreme gradient boosting (XGBoost) model built...
Invasive aspergillosis (IA) is a major cause of infectious morbidity and mortality in immune compromised patients. Studies on the pathogenesis IA have been limited by difficulty to monitor disease progression real-time. For real-time monitoring infection, we recently engineered bioluminescent A. fumigatus strain. In this study, demonstrate that bioluminescence imaging can track at different anatomic locations murine model recapitulates natural route infection. To define temporal functional...
We examined the effects of quercetin‐rich onion peel extract supplementation on adipokine expressions from adipose tissues in a diet‐induced obese animal model. Male Sprague‐Dawley rats ( n = 24) were randomly assigned into control 8), high fat diet (HF, 8) and with (HFOE, 8). After 8 weeks, serum biochemical parameters, weights (epididymal, perirenal mesenteric fats) mRNA levels (adiponectin, IL (interleukin)‐6 visfatin) along PPAR (peroxisome proliferator‐activated receptor) γ2 measured....
The reported health benefits of Korean red ginseng (KRG) include antioxidant, antitumor, antimutagenic, and immunomodulatory activities; however, the effects on oxidative stress have not yet been evaluated. Therefore, we assessed effect KRG antioxidant enzymes markers in humans.We conducted a randomized, double-blind, placebo-controlled study with three groups, including placebo, low-dose (3 g/day), high-dose (6 which were randomly assigned to healthy subjects aged 20-65 years. Lymphocyte...
Cardiovascular disease is the leading cause of death worldwide. This study aimed to investigate recent nationwide trends in major dietary risk factors for dyslipidemia and atherosclerosis. We estimated age-standardized mean intakes fresh fruits, vegetables, whole grains, fiber, sugar-sweetened beverages (SSBs); percentage energy intake from protein, total fat, saturated polyunsaturated fat using nationally representative samples Korean National Health Examination Nutrition Survey 2013-2022....
It is unclear whether lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) exerts a pro- or antiatherogenic effect on cardiovascular disease (CVD). We investigated the association between Lp-PLA(2) variant (V279F and A379V) CVD in Korean men.CVD patients (n = 532) healthy controls 670) were genotyped for polymorphism A379V).We calculated odds ratio (OR) risk measured anthropometries, lipid profiles, low-density lipoprotein (LDL) particle size, oxidized LDL, peroxides, activity.The presence...