A5022862706- Cholesterol and Lipid Metabolism
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Antioxidant Activity and Oxidative Stress
- Peroxisome Proliferator-Activated Receptors
- Phytochemistry and Biological Activities
- Steroid Chemistry and Biochemistry
- Atherosclerosis and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Phytoestrogen effects and research
- Phytochemical compounds biological activities
- Bioactive natural compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects of Natural Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Inflammatory mediators and NSAID effects
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional and Medicinal Uses of Annonaceae
- Sesquiterpenes and Asteraceae Studies
- Cancer, Lipids, and Metabolism
- Lipid metabolism and biosynthesis
- Paraoxonase enzyme and polymorphisms
- Lipoproteins and Cardiovascular Health
Korea Research Institute of Bioscience and Biotechnology
2013-2024
Korea University of Science and Technology
2005-2017
Korea University
2015
University of Pavia
2005-2008
Kyung Hee University
2006-2008
Gyeongsang National University
2006-2008
Sookmyung Women's University
2007
University of Science and Technology
2007
Chungnam National University
2006
Seoul National University
2006
The subendothelial aggregation and retention of low density lipoprotein (LDL) are key events in atherogenesis, but the mechanisms vivo not known. Previous studies have shown that treatment LDL with bacterial sphingomyelinase (SMase)in vitro leads to formation lesion-like aggregates become retained on extracellular matrix stimulate macrophage foam cell formation. In addition, aggregated human lesional LDL, unaggregated or plasma shows evidence hydrolysis by an arterial wall SMase vivo,...
Naringin, a bioflavonoid found in citrus fruit peel, is known to have an antioxidative effect, but its effect on atherosclerosis has not been studied. This study evaluated the of naringin blood lipid levels and aortic fatty streaks, action mechanism hypercholesterolemic rabbits. Male New Zealand white rabbits were fed 0.25% cholesterol diet divided into untreated group (n = 4), naringin-treated 5; 500 mg/kg per day), lovastatin-treated 20 day). After 8 weeks, was sampled analyzed...
The oxidized low-density lipoprotein (ox-LDL) plays a critical role at the early stages of atherosclerosis. Thus, prevention LDL-oxidation by antioxidants may arrest progression Two quinoline alkaloids, 3,8-dihydroxyquinoline (1) and 2,8-dihydroxy-3,4-dimethoxyquinoline (3), 2,4-di-tert-butylphenol (2) were isolated from dried body Scolopendra subspinipes. Compounds 1—3 exhibited antioxidant activities on copper-mediated (1: IC50=2.6 μM, 2: IC50=8.2 3: IC50=63.0 μM), AAPH-mediated oxidation...
This study investigated the molecular mechanisms underlying antidiabetic effect of an ethanol extract soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas db/db-ESL group was ND with 1% ESL for 8 weeks. Dietary improved glucose tolerance lowered plasma glucose, glycated hemoglobin, HOMA-IR, triglyceride levels. The pancreatic insulin content significantly greater than that group. supplementation altered IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2,...
A study was conducted to determine whether the ethanol extract of roots Brassica rapa (EBR) ameliorates cisplatin-induced nephrotoxicity in terms oxidative stress, as characterized by lipid peroxidation, reactive oxygen species (ROS) production, and glutathione (GSH) depletion LLC-PK1 cells. Pretreatment cells with EBR prevented decreases cell viability cellular GSH content. The effect then investigated rats given for 14 d before cisplatin administration. single dose (7 mg/kg, i.p.) caused...
Natural food supplements with high flavonoid content are often claimed to promote weight-loss and lower plasma cholesterol in animal studies, but human studies have been more equivocal. The aim of this study was firstly determine the effectiveness natural containing Glycine max leaves extract (EGML) or Garcinia cambogia (GCE) cholesterol. Secondly examine whether these any beneficial effect on lipid, adipocytokine antioxidant profiles.Eighty-six overweight subjects (Male:Female = 46:40, age:...
BACKGROUND AND PURPOSE Brassica rapa species constitute one of the major sources food. In present study, we investigated anti-inflammatory effects and underlying molecular mechanism arvelexin, isolated from B. rapa, on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages a model septic shock induced by LPS. EXPERIMENTAL APPROACH The expression Inducible nitric oxide synthase (iNOS) COX-2, TNF-α, IL-6 IL-1β were determined Western blot and/or RT-PCR respectively. To elucidate...