A5044956866- Liver Disease Diagnosis and Treatment
- Veterinary Oncology Research
- Liver physiology and pathology
- Muscle Physiology and Disorders
- Drug-Induced Hepatotoxicity and Protection
- Mesenchymal stem cell research
- Alcohol Consumption and Health Effects
- Helicobacter pylori-related gastroenterology studies
- Tissue Engineering and Regenerative Medicine
- Vitamin C and Antioxidants Research
- Oral and Maxillofacial Pathology
- Cell Adhesion Molecules Research
- Infectious Diseases and Mycology
- Virus-based gene therapy research
- Pluripotent Stem Cells Research
- Galectins and Cancer Biology
- Mitochondrial Function and Pathology
- Veterinary Medicine and Surgery
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- Glycosylation and Glycoproteins Research
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
Kyungpook National University
2014-2023
Hoseo University
2023
Pusan National University Yangsan Hospital
2020
Yonsei University
2020
In-Q-Tel
2013
Sunchon National University
2006
National Institute on Alcohol Abuse and Alcoholism
1999-2001
National Institutes of Health
2000-2001
National Institute of Allergy and Infectious Diseases
2001
Korea Research Institute of Bioscience and Biotechnology
1996
Mitochondria are the major organelles that produce reactive oxygen species (ROS) and main target of ROS-induced damage as observed in various pathological states including aging. Production NADPH required for regeneration glutathione mitochondria is critical scavenging mitochondrial ROS through reductase peroxidase systems. We investigated role NADP+-dependent isocitrate dehydrogenase (IDPm) controlling redox balance subsequent cellular defense against oxidative damage. demonstrate this...
A facile method of preparing triple-modality, optical–nuclear–magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence based on radionuclides showed great potential as a new optical modality. The complementary nature the optical/PET/MR hybrid nanoprobes facilitated non-invasive differentiation between tumor-metastasized sentinel lymph nodes (SLNs) and tumor-free SLNs. Detailed facts importance to specialist readers are published...
Senescence marker protein 30 (SMP30), an important aging molecule that is highly expressed in the liver, has been known to protect hepatocytes from apoptosis by synthesis of vitamin C. To explore function SMP30 liver fibrosis, effect deficiency on fibrosis was investigated knockout (KO) mice. Moreover, vivo results were further confirmed way hepatic stellate cell (HSC) isolation. We demonstrated carbon tetrachloride (CCl4)-induced and nuclear translocation p-Smad2/3, immediate downstream...
The flavonoid naringin was investigated for its differential effects on hepatic cholesterol regulation when supplemented 3 weeks and 6 weeks. Sprague-Dawley rats were fed a high-fat high-cholesterol diet with or without 0.02% supplement Supplementation resulted in significant decrease the plasma triglyceride concentrations 6-week trial. Although high-density lipoprotein (HDL)-cholesterol not altered either trial, HDL-cholesterol/total ratio (in percent) significantly higher, atherogenic...
Recently, adipose tissue-derived stem cells (ASCs) were emerged as an alternative, abundant, and easily accessible source of cell therapy. Previous studies revealed losartan (an angiotensin II type I receptor blocker) treatment promoted the healing skeletal muscle by attenuation TGF-β signaling pathway, which inhibits differentiation. Therefore, we hypothesized that a combined therapy using ASCs might dramatically improve remodeling after injury. To determine effect with ASC transplantation,...
Abstract A 4‐year‐old, neutered female Cocker Spaniel was presented to the veterinary clinic for protrusion of left third eyelid. When eyelids from both eyes were everted, lobulated masses present on bulbar surface. The eyelid had a larger protrusion. There no apparent associated ocular or systemic involvement. tumor removed and referred histological examination. Histologically, there proliferations lymphoid follicles surrounded by cells forming marginal zone. Those occasionally infiltrated...
Alcoholic liver disease is a major cause of chronic worldwide, and cannabinoid receptor type 1 (CB1R) involved in diverse metabolic diseases. B-cell translocation gene 2 (BTG2) yin yang (YY1) are potent regulator biological conditions. Melatonin plays crucial role regulating physiological functions homeostasis. MicroRNAs key regulators various processes. Herein, we demonstrate that melatonin improves bile acid synthesis the alcohol-fed mice by controlling miR-497 expression. The level...
Nogo-A (Rtn 4A), a member of the reticulon 4 (Rtn4) protein family, is neurite outgrowth inhibitor that primarily expressed in central nervous system (CNS). However, previous studies revealed was upregulated skeletal muscles Amyotrophic lateral sclerosis (ALS) patients. Additionally, experiments showed endoplasmic reticulum (ER) stress marker, C/EBP homologous (CHOP), gastrocnemius muscle murine model ALS. We therefore hypothesized might relate to diseases. According our knocking down and...
Helicobacter pylori vacuolating cytotoxin A (VacA) has been considered as an apoptosis-inducing factor. Here, we investigated the mechanism of VacA-induced apoptosis in relation to defense and MAP kinases pathway gastric epithelial cells. AGS cells exposed enriched VacA extracts affected level SOD-1 villin. We further role those inductions using a functional recombinant (rVacA). Activation p38 MAPK Bax dimerization by rVacA were increased dose-dependent manner. rVacA-induced ERK1/2...
Following liver injuries, hepatic stellate cells ( HSCs ) express α‐ SMA . Mitogen activated protein kinase MAPK signaling pathways mediate expression in distinct cell types. However, the regulation of by MAPKs has been rarely studied. We aimed to study role activation during fibrosis. Liver fibrosis rats was induced carbon tetrachloride. HSC ‐ T6 cells, murine embryonic fibroblasts, JNK1 −/− and JNK2 were used for vitro studies. Immunohistochemistry immunoblot analysis used. have found that...
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder caused by mutations in the dystrophin gene. Adipose-derived stem cells (ASCs) are attractive source of for cell therapy. Losartan has been reported to improve ASC transplantation injured mouse muscles. In present study, we investigated whether combined treatment losartan and ASCs muscles mdx mice improves regeneration. The remarkably improved muscle regeneration induced hypertrophy. addition, downregulated transforming growth...
Horse health has become a major concern with the expansion of horse-related industries and sports; importance healthy muscles for horse performance daily activities is undisputed. Here we generated equine-induced pluripotent stem cells (E-iPSCs) by reprogramming equine adipose-derived (E-ADSCs) into iPSCs using polycistronic lentiviral vector encoding four transcription factors (i.e., Oct4, Sox2, Klf4, c-Myc) then examined their characteristics. Subsequently, established E-iPSCs were...
Abstract: Background/Aims: Many studies have reported that hypoxia might be associated with angiogenesis and fibrogenesis, the level of transforming growth factor‐β1 (TGF‐β1) was increased in fibrotic liver maximal at cirrhosis. Therefore, we examined expression TGF‐β1, phosphorylated‐Smad2/3 (p‐Smad2/3) TGF‐β immediate down stream signaling system hypoxic status during hepatic fibrogenesis. Methods: Fibrosis rats induced by carbon tetrachloride. Collagens were detected Azan stain....