A5066557860- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Estrogen and related hormone effects
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Chemical Reactions and Isotopes
- Lanthanide and Transition Metal Complexes
- Cancer, Hypoxia, and Metabolism
- Cardiac Imaging and Diagnostics
- Hydraulic Fracturing and Reservoir Analysis
- Seismic Imaging and Inversion Techniques
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- Fluorine in Organic Chemistry
- Drilling and Well Engineering
- Prostate Cancer Treatment and Research
- Metal complexes synthesis and properties
- Rock Mechanics and Modeling
- Inhalation and Respiratory Drug Delivery
- HER2/EGFR in Cancer Research
- Radioactive element chemistry and processing
- Muon and positron interactions and applications
- Inflammatory mediators and NSAID effects
- Synthesis and Biological Evaluation
- Hydrocarbon exploration and reservoir analysis
Danish Gas Technology Centre (Denmark)
2018-2024
Department of Climate Change, Energy, the Environment and Water
2023
Technical University of Denmark
2017-2023
Simmons University
2023
Office of the Chief Scientist
2022
Oil and Gas Center
2019-2020
Carbon Engineering (Canada)
2020
Norsk Hydro (Germany)
2020
Allergy and Asthma Medical Group and Research Center
2002-2018
Rady Children's Hospital-San Diego
1991-2018
Abstract We propose an in vivo method for use with positron emission tomography (PET) that results a quantitative characterization of neuroleptic binding sites using radiolabeled spiperone. The data are analyzed mathematical model describes transport, nonspecific binding, the brain. demonstrates receptor quantities B max (i.e., number sites) and K D −1 affinity) not separably ascertainable tracer methodology human subjects. have, therefore, introduced new term, potential, equivalent to...
Recent evidence has defined an important role for PPARα in the transcriptional control of cardiac energy metabolism. To investigate genesis metabolic and functional derangements diabetic cardiomyopathy, mice with cardiac-restricted overexpression (MHC-PPAR) were produced characterized. The expression target genes involved fatty acid uptake oxidation pathways was increased MHC-PPAR mice. Surprisingly, glucose transport utilization reciprocally repressed hearts. Consistent gene profile,...
Recent evidence has defined an important role for PPARα in the transcriptional control of cardiac energy metabolism. To investigate genesis metabolic and functional derangements diabetic cardiomyopathy, mice with cardiac-restricted overexpression (MHC-PPAR) were produced characterized. The expression target genes involved fatty acid uptake oxidation pathways was increased MHC-PPAR mice. Surprisingly, glucose transport utilization reciprocally repressed hearts. Consistent gene profile,...
Gold nanocages represent a new class of nanomaterials with compact size and tunable optical properties in the near-infrared region. They passively accumulate tumor after intravenous injection. By exposing tumors to diode laser, photothermal effect Au selectively destroys tissue minimum damage surrounding healthy tissue.
Evidence is emerging that systemic metabolic disturbances contribute to cardiac myocyte dysfunction and clinically apparent heart failure, independent of associated coronary artery disease. To test the hypothesis perturbation lipid homeostasis in cardiomyocytes contributes dysfunction, we engineered transgenic mice with cardiac-specific overexpression fatty acid transport protein 1 (FATP1) using α-myosin heavy chain gene promoter. Two lines demonstrate 4-fold increased myocardial free (FFA)...
PURPOSE: The purpose of this study was to investigate whether positron emission tomography (PET) with the glucose analog [ 18 F]fluorodeoxyglucose (FDG) and estrogen 16 alpha-[ F]fluoroestradiol-17 beta (FES), performed before after treatment tamoxifen, could be used detect hormone-induced changes in tumor metabolism (metabolic flare) available levels receptor (ER). In addition, we investigated these PET findings would predict hormonally responsive breast cancer. PATIENTS AND METHODS: Forty...
Using H215O (half-life = 2.1 min) we demonstrated that a modification of the tissue autoradiographic approach permitted quantitation myocardial blood flow in open-chest dogs by direct assay and noninvasive estimation with positron-emission tomography (PET) delineated relative intact dogs. In anesthetized dogs, single-pass extraction fraction averaged 96 +/- 5% at flows 80 to 100 ml/100 g/min. This high did not differ significantly over range 12 238 Myocardial calculated after 60 sec...
An understanding of the metabolic fate radiometal-labeled peptides is important due to their application in areas diagnostic imaging and targeted radiotherapy. Radioisotopes copper (64Cu, T1/2 = 12.7 h; 67Cu, 62 h) have been labeled monoclonal antibodies (mAbs) applications PET radiotherapy cancer. Copper-64-TETA-d-Phe1-octreotide ([64Cu]TETA-OC) has shown bind somatostatin receptor, both vitro vivo, this agent inhibited growth somatostatin-receptor positive tumors rats. Copper-64-TETA-OC,...
In the diabetic heart, chronic activation of PPARα pathway drives excessive fatty acid (FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy. The related nuclear receptor, PPARβ/δ, is also highly expressed in yet its function has not been fully delineated. To address role myocardial metabolism, we generated transgenic mice with cardiac-specific expression driven by myosin heavy chain (MHC-PPARβ/δ mice). striking contrast to MHC-PPARα mice, MHC-PPARβ/δ had...
A biodegradable positron-emitting dendritic nanoprobe targeted at α v β 3 integrin, a biological marker known to modulate angiogenesis, was developed for the noninvasive imaging of angiogenesis. The has modular multivalent core-shell architecture consisting heterobifunctional core chemoselectively functionalized with polyethylene oxide (PEO) chains that form protective shell, which imparts stealth and dictates pharmacokinetics. Each 8 branches labeling radiohalogens. Placement radioactive...
Abstract Gold nanocages represent a novel class of nanostructures, well‐suited for biomedical applications. They can be readily prepared via the galvanic replacement reaction between silver nanocubes and chloroauric acid. Their optical resonance peaks easily precisely tuned to near‐infrared region from 650–900 nm, transparent window blood soft tissue. Furthermore, their surface conveniently conjugated with various ligands targeting cancer. In this feature article, we highlight recent...