A5091718941- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Thermography and Photoacoustic Techniques
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- Optical Coherence Tomography Applications
- Ultrasound Imaging and Elastography
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Infrared Thermography in Medicine
- Advanced X-ray and CT Imaging
- AI in cancer detection
- Epigenetics and DNA Methylation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Thermoregulation and physiological responses
- Semiconductor materials and devices
- Non-Invasive Vital Sign Monitoring
- Advanced Fluorescence Microscopy Techniques
- Ultrasonics and Acoustic Wave Propagation
- Radiomics and Machine Learning in Medical Imaging
- Near-Field Optical Microscopy
- Effects and risks of endocrine disrupting chemicals
- Advanced MRI Techniques and Applications
- Retinal Development and Disorders
Pohang University of Science and Technology
2016-2025
Pohang TechnoPark (South Korea)
2024-2025
Korea Atomic Energy Research Institute
2023-2024
Korea Research Institute of Standards and Science
2024
Chung-Ang University
2015-2024
Yonsei University
2016-2024
Dong-A University
2007-2024
Ansan University
2024
Korea University
2024
Pusan National University
2002-2023
Early diagnosis, accurate staging, and image-guided resection of melanomas remain crucial clinical objectives for improving patient survival treatment outcomes. Conventional techniques cannot meet this demand because the low sensitivity, specificity, poor spatial resolution, shallow penetration, and/or ionizing radiation. Here we overcome such limitations by combining high-resolution photoacoustic tomography (PAT) with extraordinarily optical absorbing gold nanocages (AuNCs). When...
This work demonstrated the use of Au nanocages as a new class lymph node tracers for noninvasive photoacoustic (PA) imaging sentinel (SLN). Current SLN mapping methods based on blue dye and/or nanometer-sized radioactive colloid injection are intraoperative due to need visual detection and low spatial resolution Geiger counters in detecting colloids. Compared current methods, PA shows number attractive features: noninvasiveness, strong optical absorption near-infrared region (for deep...
Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field precision nanomedicine. Here, we develop a "one-for-all" nanomaterial that self-assembles from flexible versatile phthalocyanine building blocks. The nanostructured assemblies (NanoPcTBs) display intrinsically unique photothermal photoacoustic properties. Fluorescence reactive oxygen species generation can be triggered depending on targeted,...
We present the first Korean individual genome sequence (SJK) and analysis results. The diploid of a male was sequenced to 28.95-fold redundancy using Illumina paired-end sequencing method. SJK covered 99.9% NCBI human reference genome. identified 420,083 novel single nucleotide polymorphisms (SNPs) that are not in dbSNP database. Despite close similarity, significant differences were observed between Chinese (YH), only other Asian available, SJK: (1) 39.87% (1,371,239 out 3,439,107) SNPs...
Using a hand-held photoacoustic probe integrated with clinical ultrasound array system, we successfully imaged objects deeply positioned in biological tissues. The optical contrasts were enhanced by methylene blue concentration of ~30 mM. penetration depth reached ~5.2 cm chicken breast tissue using 650-nm wavelength, which is ~4.7 times the 1/e depth. This imaging was achieved laser fluence on surface only 3 mJ/cm(2), 1/7 American National Standards Institute (ANSI) safety limit (20...
Abstract Photoacoustic imaging has attracted interest for its capacity to capture functional spectral information with high spatial and temporal resolution in biological tissues. Several photoacoustic systems have been commercialized recently, but they are variously limited by non-clinically relevant designs, immobility, single anatomical utility (e.g., breast only), or non-programmable interfaces. Here, we present a real-time clinical ultrasound system which consists of an FDA-approved...
Hexamodal imaging using simple nanoparticles is demonstrated. Porphyrin-phospholipids are used to coat upconversion in order generate a new biocompatible material. The characterized vitro and vivo for via fluorescence, upconversion, positron emission tomography, computed Cerenkov luminescence, photoacoustic tomography.
Optical-resolution photoacoustic microscopy (OR-PAM) is a novel label-free microscopic imaging tool to provide in vivo optical absorbing contrasts. Specially, it crucial equip real-time capability without sacrificing high signal-to-noise ratios (SNRs) for identifying and tracking specific diseases OR-PAM. Herein we demonstrate 2-axis water-proofing MEMS scanner made of flexible PDMS. This results wide scanning range (9 × 4 mm2 transverse plane) fast speed (5 B-scan images per second)....
Photoacoustic microscopy (PAM) has become a premier tool that can provide the anatomical, functional, and molecular information of animals humans in vivo. However, conventional PAM systems suffer from limited temporal and/or spatial resolution. Here, we present fast system an agent-free localization method based on stable commercial galvanometer scanner with custom-made scanning mirror (L-PAM-GS). This novel hardware implementation enhances resolution significantly while maintaining high...
Significance Multimodal imaging based on optics and ultrasound can provide guide images complementary structural functional information, thus improving the accuracy of medical diagnosis treatment monitoring. However, because conventional transducers are opaque, in multimodal with optics, optical devices must be placed off-axis from transducer. This arrangement is prone to misalignment, adds complexity bulk system, result a low signal-to-noise-ratio. Here, we present transparent transducer at...
Smart textiles consist of discrete devices fabricated from-or incorporated onto-fibres. Despite the tremendous progress in smart for lighting/display applications, a large scale approach display system with integrated multifunctional traditional textile platforms has yet to be demonstrated. Here we report realisation fully operational 46-inch consisting RGB fibrous LEDs coupled fibre that are capable wireless power transmission, touch sensing, photodetection, environmental/biosignal...
Abstract Thyroid cancer is one of the most common cancers, with a global increase in incidence rate for both genders. Ultrasound-guided fine-needle aspiration current gold standard to diagnose thyroid but results are inaccurate, leading repeated biopsies and unnecessary surgeries. To reduce number biopsies, we explored use multiparametric photoacoustic (PA) analysis combination American Association (ATA) Guideline (ATAP). In this study, performed vivo multispectral PA imaging on nodules from...
A superresolution imaging approach that localizes very small targets, such as red blood cells or droplets of injected photoacoustic dye, has significantly improved spatial resolution in various biological and medical modalities. However, this superior is achieved by sacrificing temporal because many raw image frames, each containing the localization target, must be superimposed to form a sufficiently sampled high-density image. Here, we demonstrate computational strategy based on deep neural...
Background Monitoring the microcirculation in human feet is crucial assessing peripheral vascular diseases, such as diabetic foot. However, conventional imaging modalities are more focused on diagnosis major arteries, and there limited methods to provide microvascular information early stages of disease. Purpose To investigate a three-dimensional (3D) noncontrast bimodal photoacoustic (PA)/US system that visualizes foot morphologically also reliably quantifies podiatric parameters...
Microplastics (MPs) are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response the human health risk assessment. However, these focused on spherical MPs, which smooth edges shape account for less than 1% of MPs nature. Unfortunately, fragment-type very limited remain initial stages. In this study, we studied effect that 16.4 µm fragment type polypropylene (PP) an irregular sharp form naturally environment, had breast cancer....