A5070643418- Photoacoustic and Ultrasonic Imaging
- Thermography and Photoacoustic Techniques
- Optical Imaging and Spectroscopy Techniques
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Optical Coherence Tomography Applications
- Thermoregulation and physiological responses
- Ultrasound Imaging and Elastography
- Non-Invasive Vital Sign Monitoring
- Ultrasonics and Acoustic Wave Propagation
- Non-Destructive Testing Techniques
- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Cancer Cells and Metastasis
- Near-Field Optical Microscopy
- Microfluidic and Bio-sensing Technologies
- Nosocomial Infections in ICU
- Vascular Tumors and Angiosarcomas
- 3D Printing in Biomedical Research
- Cell Image Analysis Techniques
- Antibiotic Use and Resistance
- Skin Protection and Aging
- Cerebrovascular and Carotid Artery Diseases
- Extracellular vesicles in disease
- Hepatitis Viruses Studies and Epidemiology
Pohang University of Science and Technology
2017-2025
Pohang TechnoPark (South Korea)
2024
Pohang Iron and Steel (South Korea)
2022
University of Ulsan
2007-2015
Asan Medical Center
2007-2015
Ulsan College
2007-2015
Ulsan University Hospital
2005
Mount Sinai Medical Center
1997
Significance Multimodal imaging based on optics and ultrasound can provide guide images complementary structural functional information, thus improving the accuracy of medical diagnosis treatment monitoring. However, because conventional transducers are opaque, in multimodal with optics, optical devices must be placed off-axis from transducer. This arrangement is prone to misalignment, adds complexity bulk system, result a low signal-to-noise-ratio. Here, we present transparent transducer at...
Background Monitoring the microcirculation in human feet is crucial assessing peripheral vascular diseases, such as diabetic foot. However, conventional imaging modalities are more focused on diagnosis major arteries, and there limited methods to provide microvascular information early stages of disease. Purpose To investigate a three-dimensional (3D) noncontrast bimodal photoacoustic (PA)/US system that visualizes foot morphologically also reliably quantifies podiatric parameters...
Abstract Transparent ultrasound transducers (TUTs) can seamlessly integrate optical and components, but acoustic impedance mismatch prohibits existing TUTs from being practical substitutes for conventional opaque transducers. Here, we propose a transparent adhesive based on silicon dioxide-epoxy composite to fabricate matching backing layers with impedances of 7.5 4–6 MRayl, respectively. By employing these layers, develop an ultrasensitive, broadband TUT 63% bandwidth at single resonance...
Functional imaging of microvascular dynamics in extremities delivers intuitive information for early detection, diagnosis, and prognosis vascular diseases. High-resolution high-speed photoacoustic microscopy (PAM) visualizes measures multiparametric microvessel networks vivo such as morphology, flow, oxygen saturation, metabolic rate. Here, we demonstrate high-resolution monitoring human fingers. We photoacoustically monitored the position displacement blood vessels associated with arterial...
Photoacoustic microscopy (PAM) is used to visualize blood vessels and monitor their time-dependent changes. Photoplethysmography (PPG) measures hemodynamic time-series changes such as heart rate. However, PPG's limited visual access the dynamic of has prohibited further understanding hemodynamics. Here, we propose a novel, fully integrated PAM photoplethysmography (PAM-PPG) system understand features in detail. Using PAM-PPG system, simultaneously acquire vascular images (by PAM) volume PPG)...
Postprandial hyperglycemia, blood glucose spikes, induces endothelial dysfunction, increasing cardiovascular risks. Endothelial dysfunction leads to vasoconstriction, and observation of this phenomenon is important for understanding acute hyperglycemia. However, high-resolution imaging microvessels during hyperglycemia has not been fully developed. Here, we demonstrate that photoacoustic microscopy can noninvasively monitor morphological changes in vessels live animals' extremities when...
Abstract Ultraviolet photoacoustic microscopy (UV‐PAM), based on the high intrinsic optical absorption of DNA/RNA, holds great promise for intraoperative label‐free histopathological imaging modalities. Although clinical histopathology requires high‐resolution images to observe individual cell structures, conventional UV‐PAM suffers from relatively low resolution compared histological Notably, opto‐ultrasound beam combiners or ring‐shaped ultrasound transducers, which have been used as...
Photoacoustic imaging (PAI) has become a powerful biomedical technique in the last decades, combining optical and ultrasound (USI) principles. Among various configurations, optical-resolution photoacoustic microscopy (OR-PAM) served as vital tool for high-resolution high-sensitivity of small animals vivo. However, current systems have limited mobility, which hinders preclinical clinical research cramped spaces. Here, we propose compact ( <inline-formula...
Dual-mode photoacoustic/ultrasound endoscopy (ePAUS) is a promising tool for preclinical and clinical interventions. To be clinically useful, ePAUS must deliver high-performance ultrasound imaging comparable to commercial systems maintain high photoacoustic performance at long working distances. This requires transducer with an intact physical aperture coaxial alignment of acoustic optical beams within the probe, challenging integration task. We present probe miniaturized, optically...
Photoacoustic (PA) imaging combines optical contrast with ultrasound (US) detection, enabling high-resolution of biological tissues greater penetration depth than conventional techniques. Among its various implementations, photoacoustic microscopy (PAM) achieves micrometer-scale resolution by focusing laser excitation and detecting ultrasonic signals, allowing for the detailed visualization microvascular structures fine tissue morphology. Over last decade, PAM speed has significantly...
Mobile and wearable healthcare electronics are widely used for measuring bio-signals using various fusion sensors that employ photoplethysmograms, cameras, microphones, ultrasound (US) sensors, accelerometers. However, the consumer demand small form factors has significantly increased as integration of multiple is difficult in mobile or devices. This study proposes two novel opto-US namely (1) a photoplethysmography (PPG)-US device (2) PPG sensor built-in smartphone with US sensor,...
SignificanceCorticosteroids—commonly prescribed medications for skin diseases—inhibit the secretion of vasodilators, such as prostaglandin, thereby exerting anti-inflammatory action by constricting capillaries in dermis. The effectiveness corticosteroids is determined degree vasoconstriction followed whitening, namely, blanching effect. However, current method observing effect indirectly evaluates effects corticosteroids.AimIn this study, we employed optical-resolution photoacoustic (PA)...
We have developed a reflection-mode switchable subwavelength Bessel-beam (BB) and Gaussian-beam (GB) photoacoustic microscopy (PAM) system. To achieve both high resolution, we tightly attached very small ultrasound transducer to an optical objective lens with numerical aperture of 1.0 working distance 2.5 mm. used axicon achromatic doublet in our system obtain the extended depth field (DOF) BB. compare DOF performance achieved BB-PAM against GB-PAM system, designed so that GB can be easily...
Abstract Optical resolution photoacoustic microscopy (OR-PAM) is a remarkable biomedical imaging technique that can selectively visualize microtissues with optical-dependent high resolution. However, traditional OR-PAM using mechanical stages provides slow speed, making it difficult to biologically interpret in vivo tissue. In this study, we developed high-speed recently commercialized MEMS mirror. This system (MEMS-OR-PAM) consists of 1-axis mirror and stage. Furthermore, study proposes...
Sentinel lymph node biopsy with an indocyanine green-based near-infrared fluorescence imaging system avoids the shortcomings of using a radioisotope or combination blue dye and radioactive tracer. To improve surgical precision, recent research has provided depth profile sentinel by fusing ultrasound imaging. Here, we present combined based on transparent transducer. The transducer enables seamless coaxial alignment beam paths, allowing bi-modal observation single region interest. Further,...
Two-dimensional matrix transducer arrays are the most appropriate imaging probes for acquiring dual-modal 3D photoacoustic (PA)/ultrasound (US) images. However, they have small footprints which limit field-of-view (FOV) to less than 10 mm × and degrade spatial resolution. In this study, we demonstrate a PA US system (using 2D array motorized scanning system) enlarge FOV of volumetric Multiple volumes were merged form wide-field image approximately 45 mm. vivo was demonstrated using rat...
Mid-infrared photoacoustic microscopy can capture biochemical information without staining. However, the long mid-infrared optical wavelengths make spatial resolution of significantly poorer than that conventional confocal fluorescence microscopy. Here, we demonstrate an explainable deep learning-based unsupervised inter-domain transformation low-resolution unlabeled images into confocal-like virtually fluorescence-stained high-resolution images. The framework is proposed for this...
Photoacoustic (PA) imaging has become invaluable in preclinical and clinical research. Endoscopic PA particular been explored as a noninvasive modality to view vasculature diagnose cancers the digestive system. However, these feasibility studies are still limited rodents or rabbits. Here, we develop fully synchronized simultaneous ultrasound photoacoustic microscopy system using two spectral bands (
Abstract Optical‐resolution photoacoustic microscopy (OR‐PAM) enables both high‐resolution and high‐contrast imaging of optical chromophores ranging from biological tissues to inorganic samples. The lateral spatial resolution OR‐PAM depends on its configuration is primarily determined by the numerical aperture objective lens. This study demonstrates a novel, lens‐free, shear‐force system using tapered fiber, serving as proof‐of‐concept toward implementation super‐resolution, near‐field...