A5036684599- Thyroid Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Neonatal Respiratory Health Research
- Photoacoustic and Ultrasonic Imaging
- BRCA gene mutations in cancer
- Thermography and Photoacoustic Techniques
- Ga2O3 and related materials
- GaN-based semiconductor devices and materials
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Semiconductor materials and devices
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Nanoplatforms for cancer theranostics
- Atherosclerosis and Cardiovascular Diseases
- 3D Printing in Biomedical Research
- Nanowire Synthesis and Applications
- Epigenetics and DNA Methylation
- IgG4-Related and Inflammatory Diseases
- Hops Chemistry and Applications
- Hedgehog Signaling Pathway Studies
- Mast cells and histamine
Catholic University of Korea
2015-2024
Kyungpook National University
2023
Seoul St. Mary's Hospital
2016-2020
Chungnam National University
2011-2016
Silla University
2014
Samsung Medical Center
2010
Sungkyunkwan University
2010
Woosuk University
2006-2009
Abstract Ultraviolet photoacoustic microscopy (UV‐PAM), based on the high intrinsic optical absorption of DNA/RNA, holds great promise for intraoperative label‐free histopathological imaging modalities. Although clinical histopathology requires high‐resolution images to observe individual cell structures, conventional UV‐PAM suffers from relatively low resolution compared histological Notably, opto‐ultrasound beam combiners or ring‐shaped ultrasound transducers, which have been used as...
Papillary thyroid carcinoma (PTC) represents a heterogeneous disease with diverse clinical outcomes highlighting need to identify robust biomarkers relevance. We applied non-negative matrix factorization-based deconvolution publicly available gene expression profiles of cancers in the Cancer Genome Atlas (TCGA) consortium. Among three metagene signatures identified, two were enriched canonical BRAF-like and RAS-like up-regulation genes involved oxidative phosphorylation cell adhesions,...
Cyclin D1 protein is aberrantly overexpressed in thyroid cancers, but mutations of the CCND1 gene are rare these tumors. We investigated rs9344 (G870A) polymorphism and expression profiles wild-type CCND1a shortened oncogenic isoform CCND1b at mRNA levels 286 Genotype AA was associated with high more frequently found cancer than benign The were higher papillary carcinoma (PTC) or other malignant However, showed no association parameters. Noninvasive follicular neoplasm papillary-like nuclear...
Background: Although most differentiated thyroid carcinomas (DTCs) have indolent behavior, DTCs with distant metastasis a poor prognosis. However, there are no validated markers that predict the risk of and prognosis DTC. We aimed to develop genetic classifier for predicting outcomes DTC patients metastases. Methods: Targeted deep sequencing 157 cancer-related genes was performed 61 A candidate mutation independent cancer samples using digital polymerase chain reaction. Results: The...
CD73 is involved in tumor immune escape and promotes the growth progression of cancer cells. The functional role expression papillary thyroid carcinoma (PTC) has not yet been established. In 511 patients with PTC, immunohistochemistry for on tissue microarrays showed that high was associated an aggressive histologic variant (p = 0.002), extrathyroidal extension < 0.001), lymph node metastasis BRAFV600E mutation 0.015). Survival analysis results had worse recurrence-free survival 0.023)....
Background: There are no reliable biomarkers to accurately differentiate indolent thyroid tumors from more aggressive cancers. This study aimed develop new DNA methylation markers for diagnosis and recurrence risk stratification of papillary carcinoma (PTC). Methods: Thyroid tumor-specific profiling was investigated in 34 fresh frozen tissues, which included nontumor (n = 7), noninvasive follicular neoplasms with papillary-like nuclear features (NIFTP, n 6) PTC 21), using the Illumina...
Background. Most patients with a preoperative diagnosis of thyroid follicular neoplasm (FN) undergo diagnostic surgery to determine whether the nodule is benign or malignant. Point mutations at NRAS codon 61 are most common observed in FN. However, clinical significance mutation remains unclear. Methods. From 2012 2013, 123 consecutive undergoing thyroidectomy for FN were evaluated prospectively. Molecular analyses performed pyrosequencing. Results. The overall malignancy rate was 48.8%...
Papillary thyroid carcinoma (PTC) is a heterogeneous tumor with various histological and molecular subtypes. EHD2 involved in endocytosis endosomal recycling. This study aimed to investigate the prognostic significance of expression PTC develop new model for predicting persistent/recurrent disease after thyroidectomy. Pathologic slides 512 consecutive patients ≥ 1 cm were retrospectively reviewed. BRAF mutation analysis immunohistochemistry performed. Clinical mRNA was analyzed 388 using The...
The challenge in managing thyroid nodules is to accurately diagnose the minority of those with malignancy. We aimed identify diagnostic and prognostic miRNA markers for nodules. In a discovery cohort, we identified 20 candidate miRNAs differentiate between noninvasive follicular neoplasms papillary-like nuclear features (NIFTP) papillary carcinomas (PTC) by using high-throughput small RNA sequencing method. then selected three (miR-136, miR-21, miR-127) that were differentially expressed PTC...
In this study, a capacitorless one-transistor dynamic random-access memory (1T-DRAM), based on polycrystalline silicon (poly-Si) nanotube structure with grain boundary (GB), is designed and analyzed using technology computer-aided design (TCAD) simulation. the proposed 1T-DRAM, 1T-DRAM cell exhibited sensing margin of 422 μA/μm retention time 213 ms at T = 358 K single GB. To investigate effect random GBs, it was assumed that number GB seven, characteristics depending location GBs were...
Abies koreana Wilson (A. koreana) is a shrub or broadly pyramidal evergreen tree endemic in the mountainous regions of South Korea. We obtained essential oil (EO) from alpine needle leaves A. by supercritical fluid extraction (SFE) method. EO was analyzed gas chromatography–mass spectrometry (GC–MS), and 68 compounds were identified constituting 95.66% oil. The major components elemol (11.17%), terpinen-4-ol (9.77%), sabinene (8.86%), 10(15)-cadien-4-ol (7.16%), α-terpineol (6.13%), α-pinene...
Mycobacterium tuberculosis (Mtb) heparin binding hemagglutinin (HBHA) is an Ag known to evoke effective host immune responses during infection. However, the molecular basis of response HBHA has not been fully characterized. In this study, we examined mechanisms by which can induce expression proinflammatory cytokines in macrophages.HBHA-induced mRNA and protein levels were determined bone marrow-derived macrophages (BMDMs) using RT-PCR ELISA analysis. The roles intracellular signaling...
Abstract It is challenging to overcome difficult-to-treat asthma, and cell-based therapies are attracting increasing interest. We assessed the effects of mesenchymal stem cell (MSC) treatments using a murine model chronic ovalbumin (OVA)-challenged asthma. developed allergic asthma OVA sensitization challenge. Human adipose-derived MSCs (hADSCs) or human bone marrow-derived (hBMSCs) were administered. measured levels resistin-like molecule-β (RELM-β). also RELM-β in patients normal controls....
Stem cell transplantation is a promising therapeutic strategy that includes both therapy and tissue engineering for the treatment of many regenerative diseases; however, efficacy safety stem depend on type used in translational applications. In this study, we validated hypothesis human nasal turbinate-derived mesenchymal cells (hTMSCs) are potential source adult clinical use bone using three-dimensional (3D) cell-printing technology. hTMSCs were cultured evaluated according to their growth,...
[Purpose] The purpose of this study was to determine the effects adjusting scapula into its ideal position through active scapular protraction on muscle activation and function upper extremity. [Subjects] Twenty female college students aged 19–21 without any physical or functional disability were subjects study. They had no history injury their extremities hands. [Methods] After initial measurements experimental group asked perform protraction; then, grip strength measured again. Every...
Background: Hashimoto thyroiditis (HT) is suspected to correlate with papillary thyroid carcinoma (PTC) development. While some HT cases exhibit histologic features of immunoglobulin G4 (IgG4)-related disease, the relationship PTC progression remains unestablished.Methods: This cross-sectional study included 426 adult patients (≥1 cm) undergoing thyroidectomy at an academic center. was identified based on its typical features. IgG4 and IgG immunohistochemistry were performed. Wholeslide...
Background: Studies in experimental models of allergic asthma have shown that mesenchymal stem cells (MSCs) therapeutic potential for T-helper 2 (T H 2) cell-mediated inflammation.However, the mechanisms underlying these effects are not fully understood and their safety has been confirmed.Methods: Using a mouse model asthma, we investigated efficacy human adipose-derived (hADSCs) or bone marrowderived (hBMSCs) according to treatment frequency timing.Results: Ovalbumin (OVA)-sensitized...