A5020741921- Pharmacological Effects of Natural Compounds
- Nitric Oxide and Endothelin Effects
- Dermatology and Skin Diseases
- Natural product bioactivities and synthesis
- Phytochemical Studies and Bioactivities
- Traditional Chinese Medicine Analysis
- Protein Kinase Regulation and GTPase Signaling
- Stress Responses and Cortisol
- Phytochemicals and Antioxidant Activities
- Ginseng Biological Effects and Applications
- NF-κB Signaling Pathways
- Tryptophan and brain disorders
- Berberine and alkaloids research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Phytochemistry and Bioactive Compounds
- Phytochemistry and Bioactivity Studies
- Garlic and Onion Studies
- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Exercise and Physiological Responses
- Heat shock proteins research
- Atherosclerosis and Cardiovascular Diseases
Dongguk University
2014-2024
National Development Institute of Korean Medicine
2016-2019
Korea Health Promotion Institute
2015-2018
Bank of Korea
2014-2016
Dunsan Korean Medicine Hospital
2015
Kyungpook National University
2007
Dongguk University WISE
2007
University of Arizona
2002
Tufts University
2002
Mie University
2002
Depression is a serious psychiatric disorder with high prevalence, and the delayed onset of antidepressant effects remains limitation in treatment depression. This study aimed to screen essential oils that have potential for rapid-acting development. PC12 BV2 cells were used identify neuroprotective at doses 0.1 1 µg/mL. The resulting candidates treated intranasally (25 mg/kg) ICR mice, followed by tail suspension test (TST) an elevated plus maze (EPM) after 30 min. In each effective oil,...
Psoriasis is a common inflammatory skin disorder, which can be associated with psychological disorders, such as anxiety and depression. This study investigated the efficacy mechanism of action natural compound coptisine using imiquimod (IMQ)-induced psoriasis mice. Coptisine reduced severity psoriasis-like lesions, decreased epidermal hyperplasia levels cytokines TNF-α, IL-17, IL-22. Furthermore, improved IMQ-induced in mice by increasing number entries time open arms elevated plus maze...
It has been known for some time that agonist-induced contractions of vascular smooth muscle are often associated with a sensitization the contractile apparatus to intracellular Ca 2+ . One mechanism suggested explain is inhibition myosin phosphatase activity. In present study, we tested hypothesis differential localization might be its inhibition. Quantitative confocal microscopy freshly dissociated, fully cells was used in parallel measurements light chain and phosphorylation. The results...
Context: Foeniculum vulgare (F. vulgare) is traditionally used to treat inflammatory diseases. Recently, anti-inflammatory and antioxidant activities of methanol extract the fruits F. were reported. To identify biologically active compounds responsible for activity, we isolated four coumarins, scopoletin, 8-methoxypsoralen, bergapten imperatorin from vulgare.
Pterocarpus santalinus L. essential oil (PSEO) is traditionally employed for treating fever and mental aberrations. We aim to explore the antidepressant potential of intranasal PSEO in social defeat stress (SDS)-expose mice identify its mechanisms components.
Many traditional herbal medicines have been re-evaluated to determine whether they enhance immune responses. In this study, the possible use of wild Panax ginseng (WPG) for enhancement host immunity in chemotherapy was investigated. cell proliferation assay, WPG significantly enhanced RAW 264.7 macrophages and protected against regression treated with methotrexate (MTX). induced production nitric oxide expression inducible synthase cyclooxygense-2 mRNA. Furthermore, cytokines including...
Herbal combinations of Rhei Radix et Rhizoma, Gardeniae Fructus, Cimicifugae and Ginseng have been used in traditional formulas to treat the symptoms heat dryness. This study investigated therapeutic effects a natural compound mixture (PSM) these herbal combinations, containing emodin, genipin, chlorogenic acid, cimigenoside, ginsenoside Rb1, for treatment psoriasis its underlying molecular mechanisms. PSM was applied topically dorsal skin lesions imiquimod‐ (IMQ‐) induced C57BL/6 mice,...
Psoriasis is a chronic, immune-mediated inflammatory skin disorder. Rheum palmatum L. common traditional medicinal herb with anti-inflammatory and immunomodulatory activities. This study aimed to investigate the anti-psoriatic effects of ethanolic extract from R. (RPE) its chemical constituents, as well mechanisms underlying their therapeutic significance. An imiquimod (IMQ)-induced psoriasis-like mouse model was used examine effect RPE in vivo. Network pharmacological analysis performed...
Cinnamic acid (CA) and its derivatives have a broad therapeutic spectrum that includes antimicrobial, antifungal, antitumoral activities. However, the vasodilative effect of CA has not been demonstrated. The present study characterizes activity mechanism in rat thoracic aorta. vasomotion aortic strips following treatment was measured an organ bath system. In addition, vascular human umbilical vein endothelial cells (HUVECs) were used bath, Western blot, nitrite, cyclic guanosine...
Aromatherapy is one of the most common safer alternative treatments for psychiatric disorders with fewer side effects than conventional drugs. Here, we investigated cinnamon essential oil (CIEO) inhalation on mouse behaviors by performing different behavioral tests. CIEO showed anxiolytic in elevated plus maze test, as inferred from increased time spent open arms and decreased closed arms. Moreover, treatment enhanced social behavior increasing total contact number, center, distance traveled...
SUMMARY Flavonoids modulate vascular tone through an endothelium‐dependent or ‐independent mechanism. Although a few mechanisms for endothelium‐independent relaxation have been suggested, such as interference with protein kinase C cAMP cGMP phosphodiesterase, the inhibition of Ca 2+ release from intracellular stores influx extracellular fluids, mode action flavonoids remains elusive. We hypothesized that treatment flavone inhibits smooth muscle contraction by decreasing phosphorylation...
Context: Schizandra chinensis Baillon (SC) is traditionally used as a medicinal plant in the Orient. Recently, SC has become recognized an adaptogen by mainstream medical community. Phytoadaptogens influence respiratory, cardiovascular, uterus myotonic, and immune activities. Atopic dermatitis (AD) allergic inflammatory skin disease caused aberrant over-reactive responses.Objective: This study assessed suppressive effect of extract (SCE) on 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD...
RNF146 is an E3 ubiquitin ligase that specifically recognizes and polyubiquitinates poly (ADP-ribose) (PAR)-conjugated substrates for proteasomal degradation. has been shown to be neuroprotective against PAR polymerase-1 (PARP1)-induced cell death during stroke. Here we report expression inducers can prevent elicited by Parkinson's disease (PD)-associated PARP1-activating stimuli. In SH-SY5Y cells, conferred resistance toxic stimuli lead PARP1 activation. High-throughput screen using a...
Cinnamyl alcohol (CAL) is known as an antipyretic, and a recent study showed its vasodilatory activity without explaining the mechanism. Here we demonstrate effect mechanism of action CAL in rat thoracic aorta. The change tension aortic strips treated with was measured organ bath system. In addition, vascular or human umbilical vein endothelial cells (HUVECs) were used for biochemical experiments such Western blot nitrite cyclic guanosine monophosphate (cGMP) measurements. attenuated...
Gastrodia elata Blume (GEB) is a traditional herbal plant that has been used in Asian countries for centuries as an anticonvulsant, analgesic, and also sedative treating general paralysis, epilepsy, vertigo, tetanus. Although numerous reports have addressed the effects of GEB against degenerative diseases, no previous study examined possible gastroprotective GEB. Here, we pretreatment with (0.02 ml/g, p.o.) mouse water immersion restraint (WIR) stress-induced gastric lesion model. Our...