A5101432563- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Acupuncture Treatment Research Studies
- Neurotransmitter Receptor Influence on Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Nail Diseases and Treatments
- Cancer-related gene regulation
- Pharmacological Effects of Natural Compounds
- Kruppel-like factors research
- Genetic Syndromes and Imprinting
- Alcoholism and Thiamine Deficiency
- PARP inhibition in cancer therapy
- Ion Channels and Receptors
- Immunotoxicology and immune responses
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Skin and Cellular Biology Research
- Alkaloids: synthesis and pharmacology
- Heat shock proteins research
- Drug-Induced Hepatotoxicity and Protection
- Asthma and respiratory diseases
- Skin Diseases and Diabetes
- Genomics, phytochemicals, and oxidative stress
Hallym University Sacred Heart Hospital
2010-2024
Kyung Hee University
2021
Daegu Haany University
2004-2018
Hallym University
2007
Abstract Reactive oxygen species ( ROS ) have been implicated in the development of behavioral sensitization following repeated cocaine exposure. We hypothesized that increased exposure would act as signaling molecules mesolimbic dopamine DA system, which might play an important role mediating reinforcing effects cocaine. The aim this study was to evaluate enhancement brain metabolic activity and scavengers on self‐administration behavior, cocaine‐induced production nucleus accumbens NAc...
Administration of cocaine increases locomotor activity by enhancing dopamine transmission. To explore the peripheral mechanisms underlying acupuncture treatment for drug addiction, we developed a novel mechanical instrument (MAI) objective stimulation. The aim this study was to evaluate whether inhibition cocaine-induced is mediated through specific nerves, afferents from superficial or deep tissues, groups nerve fibers. Mechanical stimulation point HT7 with MAI suppressed in stimulus...
Background: Psoriasis is a chronic skin disease that appears to be autoimmune in nature. Recently, it thought microbial pathogens of can affect the pathogenesis psoriasis by inducing autoimmunity. Heat‐shock proteins (HSPs) are known play an important role immune and inflammatory responses including psoriasis. Recent studies have suggested Toll‐like receptors (TLR) 2, 4 γδ T‐cell (TCR‐γδ) may recognize HSP60 as ligand consequently activate system. Methods: The biopsy specimens 12 guttate...
Previous studies have shown a possible association between psoriasis and cardiovascular risk factors.We wanted to study the factors, including metabolic syndrome.We determined relationship of with syndrome disease. For proper level low-density lipoprotein (LDL) cholesterol, we calculated proportion patients who needed lifestyle changes or drug therapy.This included 197 401 controls. We found higher prevalence (17.8%, p=0.021), disease (4.6%, p=0.044), hypertension (32.5%, p=0.000)...
Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile Korean patients has not been available to date.
Acupuncture as a therapeutic intervention is widely practiced in the treatment of many functional disorders including alcohol abuse. In present study, effects acupuncture on withdrawal syndrome (AWS) and Fos-like immunoreactivity (FLI) striatum nucleus accumbens (NAC) rats were investigated. During 3 days cessation following chronic administration ethanol (3 g/kg, i.p. for weeks), showed significant increase AWS, such hypermotility, tail rigidity, grooming tremor, an FLI dopamine terminal...
Psoriasis is associated with increased risk of cardiovascular morbidities, especially in severe cases. Severity the disease has been known to be higher prevalence these factors. However, absence robust measurements, studies date relied mostly on treatment spectrum as a proxy for severity.To evaluate relationship between psoriasis area and severity index (PASI) factors Korean patients.Presence diabetes mellitus (DM), hypertension, smoking history was surveyed through questionnaires serum...
There is a lack of response data for topical treatments psoriasis vulgaris in Asian patients.To determine the optimal maintenance regimen treatment with calcipotriol monohydrate/betamethasone dipropionate gel Korean patients vulgaris, by comparing efficacy three 8-week regimens.This was multicentre, prospective, randomized, controlled, parallel-group, open-label, phase 4 clinical trial, conducted South Korea. Patients on limbs/trunk received once-daily monohydrate (50 μg/g)/betamethasone...
Abstract Postmarketing surveillance is conducted to establish drug safety and effectiveness under real‐world practice. We aimed validate the of ustekinumab in treatment adult Korean patients with plaque psoriasis This was a prospective, observational, multi‐center study. Subjects aged 18 years or older who were treated for enrolled. enrolled 977 patients; 654 (66.9%) men, mean body surface area (BSA, ± standard deviation) 27.0 18.3% severity index (PASI) score 18.1 9.7. The analysis...
Behavioral sensitization, as evidenced by the progressive enhanced locomotor response to a subsequent injection of drug, is major behavioral outcome produced repeated injections nicotine, and model for studying drug addiction. It putatively regarded that alteration extracellular dopamine release in nucleus accumbens closely associated with nicotine-induced sensitization. The present study was performed evaluate effects essential oil from Angelica gigas NAKAI (on fragrance inhalation) on...
Sipjeondaebo-tang (SDT) is used frequently as a herbal prescription to treat deficiency syndromes in traditional Korean medicine. We investigated the hepatoprotective effects of SDT against oxidative stress and attempted clarify underlying molecular mechanisms. pretreatment reduced arachidonic acid (AA) plus iron-mediated cytotoxicity concentration-dependent manner prevented changes apoptosis-related protein expression. In addition, significantly glutathione depletion, hydrogen peroxide...
Krüppel-like factor 4 (KLF4) is a transcription that regulates diverse array of cellular processes, including development, differentiation, proliferation, and apoptosis. Although its function in keratinocytes has been widely studied, exact role psoriasis not elucidated.We designed this study to investigate epidermal expression levels KLF4 the change after treatment patients with psoriasis.We compared basal, suprabasal, superficial layers, psoriatic lesional, non-lesional, normal skin, using...
Sensitive skin is a subjective cutaneous hyper-reactivity that occurs in response to various innocuous stimuli. Keratinocytes have recently been shown participate sensory transduction by releasing many neuroactive molecules bind intra-epidermal free nerve endings and modulate nociception. In the literature, characterization of these interactions has based on co-culture keratinocyte mammalian-origin neuronal cell lines. this study, we established an vitro model primary human keratinocytes...
The development of therapies for psoriasis has led to the need a new strategy treatment patients with moderate-to-severe psoriasis. New consensus guidelines have been developed in some countries, which introduced goals determine timing therapeutic regimens To investigate opinions held by Korean dermatologists who specialize about goals, and compare these European consensus. were asked 11 questions defining questionnaire included factors used classify severity psoriasis, induction maintenance...
Abstract All parts of Thanakha ( Hesperethusa crenulata R.) have been used as traditional skin care herbal material in Myanmar. In this study, coumarins from H. R. bark were isolated through solvent extraction, systematic fractionation, and repeated column chromatography. Spectroscopic analyses using ESI–MS, 1D NMR (1H 13C), 2D (gHSQC gHMBC), specific rotation, circular dichroism, IR spectrometry revealed three 2 R -7-hydroxy-8-(2,3-dihydroxy-3-methylbutyl)-coumarin (compound 1 ), peucedanol...
Objectives : Liver is one of the largest organs in human, and has a function detoxification energy sensing to prevent severe disease. Paeoniae radix been used treat variety liver diseases such as hepatitis chronic hepatic failure. Although P. an medicinal herb for long time, effects on oxidative stress its action mechanism was not clearly verified.Methods This study investigated protective extract (PRE), underlying liver. tert-butyl hydroperoxide (t-BHP) carbon tetrachlroride...
Psoriasis and psoriatic arthritis (PsA) are included in the group of immune-mediated inflammatory diseases (IMIDs) caused by systemic inflammation; however, indicators for monitoring activity patients with psoriasis, such as Area Severity Index (PASI), limited.To determine whether Psoriatic Arthritis Screening Evaluation (PASE) questionnaire can be used to monitor disease psoriasis.This was a multicenter, noninterventional, cross-sectional study. Demographic factors PASI PASE scores were...