A5067406841- Seaweed-derived Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- Echinoderm biology and ecology
- Neuroinflammation and Neurodegeneration Mechanisms
- Glycosylation and Glycoproteins Research
- Medicinal Plants and Neuroprotection
- Microtubule and mitosis dynamics
- Alzheimer's disease research and treatments
- Cellular transport and secretion
- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Carbohydrate Chemistry and Synthesis
- RNA regulation and disease
- RNA Research and Splicing
- Cholesterol and Lipid Metabolism
- Receptor Mechanisms and Signaling
- Pharmacological Effects of Natural Compounds
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Algal biology and biofuel production
- Protein Hydrolysis and Bioactive Peptides
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Bioactive Compounds
Dongguk University
2015-2024
Dongguk University WISE
2002-2012
Kyungpook National University
2004
California Institute of Technology
1996
University of New Brunswick
1991
We purified an abundant protein of apparent molecular mass 180 kDa from the postsynaptic density fraction rat forebrain and obtained amino acid sequences three tryptic peptides generated protein. The were used to design a strategy for cloning cDNA encoding by polymerase chain reaction. open reading frame encodes novel predicted 167 kDa. have named densin-180. Antibodies raised against carboxyl densin-180 recognize band on immunoblots that is enriched in fraction. Immunocytochemical...
Sulfotransferase 1A1 (SULT1A1) is responsible for catalyzing various types of endogenous and exogenous compounds. Accumulating data indicates that the polymorphism rs9282861 (R213H) inefficient enzymatic activity associated with cancer progression. To characterize detailed functional consequences this mutation behind loss-of-function SULT1A1, present study deployed molecular dynamics simulation to get insights into changes in conformation binding energy. The scenario SULT1A1 both wild...
Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance anti-amyloidogenic potentials algal endorse protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, impaired proteostasis which known implicated in...
Abstract Nanoparticles (NPs) have a critical function in mitigating the disease of fruits and vegetables. In present investigation, effects three levels concentrations (0.05, 0.10, 0.20 mg/mL) titanium dioxide NPs (TiO 2 -NPs) silicon (SiO were investigated against fungus Phomopsis vexans , bacterium Ralstonia solanacearum Meloidogyne incognita (root-knot nematode). The investigation’s findings found that application SiO -NPs was more efficient test pathogens comparison to TiO -NPs. best...
By combining in situ hybridization (ISH) and immunocytochemistry (IC), microscopic topological localization of mRNAs proteins can be determined. Although this technique applied to a variety tissues, it is particularly important for use on neuronal cells which are morphologically complex specific located distinct subcellular domains such as dendrites dendritic spines. One common technical problem combined ISH IC that the signal immunocytochemical often becomes much weaker after conducting...
Neurotrophic factors are vital not only to support neuronal development but also protect mature neurons from atrophy in neurodegenerative diseases. As an effort explore natural sources that possess neurotrophic activity, we screened common marine algae for their neuritogenic activity the developing rat hippocampal culture. Of 22 seaweed species examined, ethanol extracts of Gelidium amansii (GAE) exhibited potent followed by Undaria pinnatifida and Sargassum fulvellum extracts. The effects...
Age-related neurological disorders are of growing concern among the elderly, and natural products with neuroprotective properties have been attracting increasing attention as candidates for prevention or treatment induced by oxidative stress. In an effort to explore resources, we collected some common marine seaweed from Korean peninsula Indonesia screened them activity against hypoxia/reoxygenation (H/R)-induced Of 23 seaweeds examined, ethanol extract Gracilariopsis chorda (GCE) provided...
Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism its neuroprotection poorly understood. Here, we employed system pharmacology silico analysis to elucidate underlying neuropharmacological action against neurodegenerative disorders...
Recently, the critical roles played by genetic variants of TREM2 (Triggering Receptor Expressed on Myeloid cells 2) in Alzheimer's disease have been aggressively highlighted. However, few studies focused deleterious Nasu-Hakola (NHD) associated variants. In order to get insights into contributions made these neurodegeneration, we investigated influences four NHD mutations (Y38C, W50C, T66M, and V126G) loss-of-function, followed this with silico prediction conventional molecular dynamics...