A5043258621- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gut microbiota and health
- Vascular Tumors and Angiosarcomas
- Retinoids in leukemia and cellular processes
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Digestive system and related health
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Systemic Sclerosis and Related Diseases
- Histiocytic Disorders and Treatments
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2016-2025
Seoul National University
2014
Catholic University of America
2014
Kyungpook National University
2014
BC Cancer Agency
2010-2013
Terry Fox Research Institute
2013
St. Vincent's Hospital
2012
Clinical Research Management
2005
In this study, we examined BRAF mutation in a wide range of histiocytic and dendritic cell neoplasms compared its detection rate each disease group.A total 129 cases histiocytic, other related lesions were reviewed from the archives 10 hospitals Korea. The consisted sarcoma, follicular (FDC) interdigitating Langerhans histiocytosis (LCH), blastic plasmacytoid neoplasm, acute monocytic leukaemia M5, giant tumour, xanthogranuloma, inflammatory myofibroblastic tumour Rosai-Dorfman disease....
Extranodal NK/T-cell lymphoma (ENKTCL) is associated with latent Epstein-Barr virus (EBV) infection and frequent relapse even after complete response (CR) to intensive chemotherapy radiotherapy. The expression of EBV proteins in the tumor provides targets for adoptive immunotherapy antigen-specific cytotoxic T cells (CTL). To evaluate efficacy safety membrane protein (LMP)-1 LMP-2a-specific CTLs (LMP1/2a CTLs) stimulated LMP1/2a RNA-transferred dendritic cells, we treated 10 ENKTCL patients...
Aquaporins (AQPs) have previously been associated with increased expression in solid tumors. However, its hematologic malignancies including CML has not described yet. Here, we report the of AQP5 cells by RT-PCR and immunohistochemistry. While normal bone marrow biopsy samples (n = 5) showed no AQP5, 32% patient 41) demonstrated expression. In addition, level emergence imatinib mesylate resistance paired (p 0.047). We found that overexpression K562 resulted cell proliferation. small...
Abstract With contrasting observations on the effects of β-catenin hematopoietic stem cells (HSCs), precise role Wnt/β-catenin signals HSC regulation remains unclear. Here, we show a distinct mode signal that can regulate HSCs in stroma-dependent manner. Stabilization bone marrow stromal promoted maintenance and self-renewal contact-dependent manner, whereas direct stabilization caused loss HSCs. Interestingly, canonical Wnt receptors accumulation were predominantly enriched rather than...
Regulation of tumor microenvironment is closely involved in the prognosis Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) an enzyme acting as immune modulator through suppression T-cell immunity. This study aims to investigate role IDO HL.A total 121 cases HL were enrolled do immunohistochemistry for IDO, CD163, CD68, CD4, CD8, and FoxP3. Positivity was evaluated from area fractions or numbers positive cells using automated image analyzer. Correlations between expression various...
We aimed to investigate MYC expression and chromosomal aberration in mantle cell lymphoma (MCL), the clinical significance of these factors.Sixty-five patients with MCL, including 54 classic, nine blastoid two pleomorphic variants, were enrolled. Expression MYC, Ki67 p53 was assessed by immunohistochemistry. amplification or translocation examined fluorescence in-situ hybridization. higher blastoid/pleomorphic MCL variants (mean, 19.0%) than classic 1.9%; P < 0.001). also significantly...
Human chronic graft-versus-host disease (GVHD) shares clinical characteristics with a murine sclerodermatous GVHD model that is characterized by skin thickening and lung fibrosis. A B10.D2 → BALB/c transplant of was used to address the therapeutic effect mesenchymal stem cells (MSCs) on development GVHD. The pathological severity cutaneous significantly attenuated in MSC-treated recipients relative control subjects. After MSC treatment, collagen production reduced, consistent down-regulation...
Abstract Background Inflammatory bowel disease is a chronic and excessive inflammation of the colon small intestine. We previously reported that priming mesenchymal stromal cells (MSCs) with poly(I:C) induced them to express indoleamine 2,3-dioxygenase (IDO). tried find out whether IFN-γ poly(I:C)-primed MSCs have better therapeutic efficacy on experimental colitis in IDO1-dependent manner. Methods To compare effects between unstimulated primed murine colitis, mice (C57BL6) were administered...
Objectives: In this single-center retrospective study, we aimed to verify the extent of duodenal follicular lymphoma (DFL) and investigate role clinical significance video capsule endoscopy (VCE) in treatment process. Methods: We analyzed imaging data 40 patients diagnosed with DFL. Results: Imaging workup bone marrow biopsies revealed DFL only gastrointestinal tract (stage I) 22 local lymph nodes II1), distant II2), pancreas II2Epancreas), extranodal regions IV) 1, 3, 13 patients,...
Background/Objectives This study aimed to evaluate whether very early interim 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed (CT) after a single cycle of first-line chemotherapy predicts long-term survival outcome in patients with diffuse large B-cell lymphoma (DLBCL). Methods A total 51 (31 males and 20 females; mean age 55 years) had four FDG PET/CT studies, at baseline one, three, six cycles (PET0, PET1, PET3, PET6). Visually quantitatively assessed PET...
Self-renewal of hematopoietic stem cells (HSCs) is key to their reconstituting ability, but the factors regulating process remain poorly understood. Here, we show that Interleukin-10 (IL-10), a pleiotropic immune modulating cytokine, can also play role in HSC self-renewal. First, quantitative decrease primitive cell populations, not more matured cells, was observed bone marrows IL-10 disrupted mice as determined by long-term vitro cultures or vivo competitive repopulation assays. In...
Abstract: The proteasome inhibitor, bortezomib, has anti‐myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor‐ κ B (NF B)‐mediated pro‐inflammatory cytokines. We report a patient with who developed cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. LV exhibited marked increase serum levels IL‐6, TNF‐ α , and C‐reactive protein (CRP). administration may enhance release cytokines, which might play...
Abstract Despite the wide use of mesenchymal stromal cells (MSCs) for paracrine support in clinical trials, their variable and heterogeneous supporting activity pose major challenges. While three-dimensional (3D) MSC cultures are emerging as alternative approaches, key changes cellular characteristics during 3D-spheroid formation remain unclear. Here, we show that MSCs 3D spheroids undergo further progression towards epithelial-mesenchymal transition (EMT), driven by upregulation...
Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and radiomic features, BMBx results. A total of 328 were included; 269 (82%) PET-negative 59 (18%) PET-positive for lesions on assessment. fair degree agreement was present between (ĸ = 0.362, p < 0.001). Bone involvement lead to stage IV 12 patients, despite no other evidence extranodal lesion. Of 35 discordant BMBx-negative cases,...
Abstract Friend Leukemia Virus Integration 1 (FLI-1) is a member of E26 transformation-specific family transcription factors that participates in hematopoietic and vascular endothelial cell development. Immunohistochemical detection FLI-1 has been widely used to diagnose tumors or, more evidently, Ewing’s sarcoma. However, the expression pattern hematolymphoid neoplasms remains unclear. Therefore, this study, we aimed investigate these tumors, focusing on high-grade lesions, which presents...
We tried to investigate the expression rate of human papillomavirus (HPV) L1 capsid protein in uterine cervical specimens and correlate it with grade dysplasia, HPV genotype age patients. Among proved have by DNA genotyping test, eighty cytology-biopsy matched cases 22 unmatched cytology were selected. Immunostaining for was performed on both smears tissue sections. The expressed mainly nuclei, but occasionally cytoplasm cells located superficial layer squamous epithelium. immunostaining...
Bone marrow mesenchymal stromal cells (MSCs) have been implicated in the microenvironmental support of hematopoietic stem (HSCs) and often co-transplanted with HSCs to facilitate recovery ablated bone marrows. However, precise effect transplanted MSCs on HSC regeneration remains unclear because kinetics self-renewal vivo after co-transplantation has not monitored. In this study, we examined effects intrafemoral injection rigorous competitive repopulating unit (CRU) assays using congenic...
F-18-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is essential for monitoring response to treatment in patients with diffuse large B-cell lymphoma (DLBCL) and qualitative interpretation commonly applied clinical practice. We aimed evaluate the interobserver agreements of PET/CT DLBCL predictive value results outcome. images were obtained 3 times: at baseline, after cycles first-line chemotherapy (interim), completion chemotherapy. Two nuclear medicine...
Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly owing to their immunosuppressive properties. The goal of the study was determine whether TLR ligands can enhance therapeutic efficacy bone marrow-derived MSCs treatment bowel disease. Mice (C57BL6) were administered with 4% dextran sulfate sodium (DSS) in drinking water 7 days and injected on 1 3 following DSS ingestion. Our results demonstrated that among various ligands, treated...