A5100646675- Genomics and Phylogenetic Studies
- Literature Analysis and Criticism
- Hydrology and Sediment Transport Processes
- Cancer Cells and Metastasis
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Probiotics and Fermented Foods
- Fish Ecology and Management Studies
- Pregnancy and preeclampsia studies
- Genetic Associations and Epidemiology
- Pain Management and Opioid Use
- Hematopoietic Stem Cell Transplantation
- Cognitive Abilities and Testing
- Advanced Materials and Mechanics
- Photosynthetic Processes and Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Water Quality and Resources Studies
- Shakespeare, Adaptation, and Literary Criticism
- Gut microbiota and health
- Acute Myeloid Leukemia Research
- Nutritional Studies and Diet
- Mesenchymal stem cell research
- Microbial Community Ecology and Physiology
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
Korea University
2021-2025
Catholic University of Korea
2009-2024
Pohang University of Science and Technology
2024
Cedars-Sinai Medical Center
2022-2024
Seoul National University Hospital
2023
Seoul National University
2005-2022
London School of Hygiene & Tropical Medicine
2021
Soonchunhyang University
2018-2021
Hongik University
2021
Laser Scan Engineering (United Kingdom)
2021
Variovorax paradoxus is a microorganism of special interest due to its diverse metabolic capabilities, including the biodegradation both biogenic compounds and anthropogenic contaminants. V. also engages in mutually beneficial interactions with bacteria plants. The complete genome sequence S110 composed 6,754,997 bp 6,279 predicted protein-coding sequences within two circular chromosomes. Genomic analysis has revealed multiple features for autotrophic heterotrophic lifestyles. These...
Background Smokers tend to weigh less than never smokers, while successful quitting leads an increase in body weight. Because smokers and non-smokers may differ genetic environmental family background, we analysed data from twin pairs which the co-twins differed by their smoking behaviour evaluate if association between mass index (BMI) remains after controlling for background. Methods findings The international CODATwins database includes information on BMI measured 1960 2012 156,593...
Abstract With contrasting observations on the effects of β-catenin hematopoietic stem cells (HSCs), precise role Wnt/β-catenin signals HSC regulation remains unclear. Here, we show a distinct mode signal that can regulate HSCs in stroma-dependent manner. Stabilization bone marrow stromal promoted maintenance and self-renewal contact-dependent manner, whereas direct stabilization caused loss HSCs. Interestingly, canonical Wnt receptors accumulation were predominantly enriched rather than...
The design of smart and functional nanocarriers for drug delivery systems that use a variety organic inorganic materials has led to the development nanomedicines with improved therapeutic efficiency reduced side effects. In this study, pH- temperature-responsive, controlled-release system high capacity loading was developed based on radially porous silica nanoparticles composed functionalized ligands polymer encapsulation. This uses oriented mesoporous as carrier, control surface chemistry...
Objective The objective of this study was to analyze how parental education modifies the genetic and environmental variances BMI from infancy old age in three geographic‐cultural regions. Methods A pooled sample 29 cohorts including 143,499 twin individuals with information on 1 79 years (299,201 measures) analyzed by modeling. Results Until 4 age, not consistently associated BMI. Thereafter, higher level lower males females. Total additive were smaller offspring highly educated parents than...
Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting possible effect environment. By utilizing classical twin design which allows decomposing the variation into genetic and environmental components, we tested hypothesis that is greater offspring lower educated parents. Twin data from 29 cohorts including 65,978 complete pairs with information on at ages 1 to 69 years parental...
There is evidence that birth size positively associated with height in later life, but it remains unclear whether this explained by genetic factors or the intrauterine environment. To analyze associations of weight, length and ponderal index from infancy through adulthood within mono- dizygotic twin pairs, which provides insights into role environmental individual-specific factors. This study based on data 28 cohorts 17 countries. The pooled included 41,852 complete pairs (55% monozygotic...
Evidence for the concept of "gut-brain axis" (GBA) has risen. Many types research demonstrated mechanism GBA and effect probiotic intake. Although many studies have been reported, most were focused on neurodegenerative disease and, it is still not clear what type bacterial strains positive effects. We designed an experiment to discover a strain that positively affects brain function, which can be recognized through changes in cognitive processes using healthy mice. The experimental group...
We report on the out-of-plane thermal conductivities of epitaxial Fe3O4 thin films with thicknesses 100, 300, and 400 nm, prepared using pulsed laser deposition (PLD) SiO2/Si substrates. The four-point probe three-omega (3-ω) method was used for conductivity measurements in temperature range 20 to 300 K. By measuring temperature-dependent characteristics films, we realized that their significantly decreased decreasing grain size thickness films. were found be 0.52 3.51 W/m · K at For 100-nm...
Molecular characterization technology in genetically modified organisms, addition to how transgenic biotechnologies are developed now require full transparency assess the risk living and non-modified organisms. Next generation sequencing (NGS) methodology is suggested as an effective means genome detection of insertion locations. In present study, we applied NGS insert loci, specifically epidermal growth factor (EGF) rice cells. A total 29.3 Gb (~72× coverage) was sequenced with a 2 × 150 bp...
Abstract Accumulating studies have shown the cellular nature of hematopoietic stem cell (HSC) niche in bone marrow (BM) and their degenerative changes under leukemic conditions. However, dynamic adaptation cells to physiological stimulatory signals remains largely uncharacterized. Here, we established a stimulation model induced by 5-fluorouracil. This reveals rapid reversible conversion mesenchymal into niche-like stromal cells, which exhibit platelet-derived growth factor...
Acne is a chronic inflammatory skin disease induced by Cutibacterium acnes. Recently, the effects of probiotics, prebiotics and synbiotics have been researched for treatment diseases in humans. However, synbiotic effect probiotics prebiotic Curcuma longa rhizome extract (CLE) on C. acnes remains ambiguous. Therefore, aim this study was to investigate synergistic antibacterial activities probiotic lactic acid bacteria (LAB) with CLE as against Agar well diffusion assays were performed...
Over the past decades, accumulating evidences have highlighted gut microbiota as a key player in brain functioning via microbiota-gut-brain axis, and accordingly, beneficial role of several probiotic strains cognitive ability also been actively investigated. However, majority research demonstrated effects against age-related decline or neurological disease. To this end, we aimed to investigate lactic acid bacteria having on function healthy young mice elucidate underlying characteristics by...
The aim of this study was to describe a ventral laparoscopic technique for bilateral medial iliac lymphadenectomy in dogs. Twelve intact male purpose-bred research dogs, weighing less than 15 kg, were positioned dorsal recumbency, and 3-portal used. Bilateral dissection performed with vessel-sealing devices while tilting the surgical table by up 30° towards contralateral side target lymph node (MILN) without changing surgeon's position. Using approach, MILNs identified excised all mean times...
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling inferences made studies general. We analyzed whether there were differences individual, maternal paternal education between MZ DZ large pooled dataset. Information was gathered on individual 218,362 adult 27 cohorts (53% females; 39% twins), 147,315 143,056 respectively, 28 (52% 38% twins). Together, we had information or parental 42 representing 19...
Plants are sessile and rely on a wide variety of growth hormones to adjust development in response internal external stimuli. We have identified gene, designated NAN, encoding basic helixloop-helix (bHLH) transcription factor that regulates cell elongation seed germination plants. NAN has an HLH motif its C-terminal region but does not any other discernible homologies bHLH proteins. A bipartite nuclear localization signal is located close the motif. An Arabidopsis mutant, nan-1D, which...
VVZ-149 is a small molecule that both inhibits the glycine transporter type 2 and serotonin receptor 5 hydroxytryptamine A. In randomized, parallel-group, double-blind trial (NCT02844725), we investigated analgesic efficacy safety of Injections, which under clinical development as single-use injectable product for treating moderate to severe postoperative pain.Sixty patients undergoing laparoscopic robotic-laparoscopic gastrectomy were randomly assigned receive 10-hour intravenous infusion...
Background There is evidence that birth weight positively associated with education, but it remains unclear whether this association explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed between and educational years within twin pairs, which controls for environment shared co-twins. Methods The data were derived from nine cohorts in eight countries including 6116 complete pairs. attainment was both individuals pairs using linear regression...