A5039735690- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Clinical Research Studies
- Carcinogens and Genotoxicity Assessment
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Bioactive Natural Diterpenoids Research
- Pharmacogenetics and Drug Metabolism
- Animal testing and alternatives
- Connexins and lens biology
- Pluripotent Stem Cells Research
- Bacteriophages and microbial interactions
- Dermatology and Skin Diseases
- Alcohol Consumption and Health Effects
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Organ Transplantation Techniques and Outcomes
- Chemotherapy-induced organ toxicity mitigation
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- CRISPR and Genetic Engineering
- Renal and related cancers
Seoul National University
2001-2025
Catholic University of Korea
2017-2022
Cornell University
2012-2022
Bucheon St. Mary's Hospital
2017-2021
Pfizer (United Kingdom)
2021
Yonsei University
2019
Seoul National University Hospital
2014-2016
Ulsan College
2015
University of Ulsan
2015
National Institute on Alcohol Abuse and Alcoholism
2013-2014
Mesenchymal stem cell (MSC) is a promising tool for the therapy of immune disorders. However, their efficacy and mechanisms in treating allergic skin disorders are less verified. We sought to investigate therapeutic human umbilical cord blood-derived MSCs (hUCB-MSCs) against murine atopic dermatitis (AD) explore distinct that regulate efficacy. AD was induced mice by topical application Dermatophagoides farinae. Naïve or activated-hUCB-MSCs were administered mice, clinical severity...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, causes life-threatening disease. This novel enters host cells via tract, promoting formation severe pulmonary lesions and systemic Few animal models can simulate clinical signs pathology COVID-19 patients. Diverse preclinical studies using K18-hACE2 mice Syrian golden hamsters, which are highly permissive to SARS-CoV-2 in emerging; however, pathogenesis cellular tropism these remain obscure. We...
Aims: Glutathione peroxidase (GPX) mimic ebselen and superoxide dismutase (SOD) copper diisopropylsalicylate (CuDIPs) were used to rescue impaired glucose-stimulated insulin secretion (GSIS) in islets of GPX1 and(or) SOD1-knockout mice. Results: Ebselen improved GSIS all four tested genotypes. The the knockout resulted from a coordinated transcriptional regulation key regulators was mediated by peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α)-mediated signaling...
After the outbreak of acute renal failure associated with melamine-contaminated pet food, many attempts have been made to uncover mechanism underlying toxicity caused by melamine and melamine-related compounds. Using rat models, we investigated crystal formation following ingestion a melamine-cyanuric acid mixture (M+CA, 1:1) gain insight into M+CA-induced toxicity. M+CA did not induce in precision-cut kidney slices, suggesting that does direct nephrotoxicity. On contrary, oral...
Fisetin was reported to have an anti-proliferative and apoptotic activity as a novel anti-cancer agent in various cancer cell lines. However, the possible molecular targets for effect of fisetin human head neck (HNCC) not yet been clarified. In this study, influence on growth apoptosis HNCCs were examined. HSC3 cells, treatment reduced viability induced apoptosis. Through results from screening expression profile apoptosis-related genes, sestrin 2 (SESN2) functionally involved...
The Omicron variant has become the most prevalent SARS-CoV-2 variant. is known to induce milder lesions compared original Wuhan strain. Fatal infection of strain into brain been well documented in COVID-19 mouse models and human cases, but apparent infections by have not reported adult cases or animal models. In this study, we investigated whether could spread using K18-hACE2 mice susceptible infection. were intranasally infected with 1 × 105 PFU SARS-CoV-2. A follow-up was conducted 7 days...
The global regulator Mlc is a repressor of several genes and operons that are involved in sugar uptake metabolism. A Salmonella enterica serovar Typhimurium mlc mutant showed reduced levels invasion cytotoxicity compared to the wild-type, exhibited expression hilD, hilA invF, which regulatory pathogenicity island 1 (SPI1). However, effects on hilD bacterial invasiveness were not seen hilE mutant, was increased suggests exerts positive SPI1 by reducing HilE, known down-regulate through direct...
Amorphous silica nanoparticles (SiO2NPs) have been widely used in medicine including targeted drug/DNA delivery, cancer therapy, and enzyme immobilization. Nevertheless, SiO2NPs should be with caution due to safety concerns associated unique physical chemical characteristics. The objective of this study was determine the effects on genotoxic non-genotoxic mechanisms abnormal gap junctional intercellular communication (GJIC) multistage carcinogenesis. exhibited negative responses standard...
This study was designed to determine whether dietary epigallocatechin-3-gallate (EGCG), the most abundant catechin polyphenol in green tea, can protect liver from cytochrome P450 2E1 (CYP2E1)-dependent alcoholic damage. Compared with an ethanol group, when EGCG present diet, formation of a fatty significantly reduced and serum aspartate transaminase (AST) alanine (ALT) levels were much lower. Ethanol treatment elevated hepatic CYP2E1 expression while simultaneously reducing phospho-acetyl...
In vitro follicle growth (IVFG) strategy is critical in the fertility preservation of cancer survivors; however, its optimal protocol needs to be developed using primate models since availability human samples limited. Only a few previous studies have reported successful IVFG rhesus monkey ovaries low-dose follicle-stimulating hormone (FSH) (0.3 or 3 ng/mL) and long-term culture (up 5 weeks) it still uncertain regard duration effective dose treated gonadotropins applicable preantral...
Viral load and the duration of viral shedding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants transmission disease 2019. In this study, we examined effects doses on lung spleen K18-hACE2 transgenic mice by temporal histological transcriptional analyses. Approximately, 1×10
Adiponectin, which is expressed exclusively in adipose tissue, has been shown to increase fatty acid oxidation via activation of AMP-activated kinase (AMPK) and phosphorylation acetyl CoA carboxylase (ACC). ACC carnitine palmitoyl-transferase-1 (CPT1) activity have be rate controlling factors oxidation. In high fat diet (HFD)-induced obese mice, we analyzed the time-course changes expression adiponectin lipid oxidative enzymes induced by treatment with bisphenol A diglycidyl ether (BADGE) or...