Young Been Kim
A5042870777- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- RNA regulation and disease
- RNA modifications and cancer
Seoul National University Bundang Hospital
2022-2024
Viral load and the duration of viral shedding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants transmission disease 2019. In this study, we examined effects doses on lung spleen K18-hACE2 transgenic mice by temporal histological transcriptional analyses. Approximately, 1×10
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and potentially fatal virus. So far, most comprehensive analyses encompassing clinical transcriptional manifestation have concentrated on the lungs. Here, we confirmed evident signs of viral infection in lungs spleen SARS-CoV-2-infected K18-hACE2 mice, which replicate phenotype symptoms hospitalized humans. Seven days post detection organs, infected mice showed decreased vital signs, leading to death....
Abstract Translational regulation in tissue environments during vivo viral pathogenesis has rarely been studied due to the lack of translatomes from virus-infected tissues, although a series translatome studies using vitro cultured cells with infection have reported. In this study, we exploited tissue-optimized ribosome profiling (Ribo-seq) and severe-COVID-19 model mice establish first temporal translation profiles virus host genes lungs SARS-CoV-2 pathogenesis. Our datasets revealed not...