A5100652835- MicroRNA in disease regulation
- Advanced Surface Polishing Techniques
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Bacteriophages and microbial interactions
- Extracellular vesicles in disease
- Cultural and Historical Studies
- RNA Research and Splicing
- Adhesion, Friction, and Surface Interactions
- Covalent Organic Framework Applications
- Corporate Finance and Governance
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Hydrogels: synthesis, properties, applications
- Vibrio bacteria research studies
- Diamond and Carbon-based Materials Research
- interferon and immune responses
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- NF-κB Signaling Pathways
- Enterobacteriaceae and Cronobacter Research
- Acute Myeloid Leukemia Research
- Agriculture Sustainability and Environmental Impact
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
Seoul National University
2007-2025
The Ohio State University
2025
National Cancer Center
2024
Kangwon National University
2023-2024
Konkuk University
2023-2024
Pusan National University
2024
Sogang University
2023
Yonsei University
2021-2023
Sejong University
2023
University of Seoul
2023
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infected >200 million people resulting in >4 deaths. However, temporal landscape of the SARS-CoV-2 translatome and its impact on human genome remain unexplored. Here, we report a high-resolution atlas transcriptome for various time points after infecting cells. Intriguingly, substantial amount translation initiates at novel initiation site (TIS) located leader sequence, termed TIS-L. Since TIS-L...
Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among currently identified >1,500 human RNA-binding proteins (RBPs), there are only a handful RBPs known to enhance MT and several others reported suppress MT, leaving global impact on elusive. In this study, we have systematically analyzed transcriptome-wide binding sites for 150 evaluated quantitative effect individual efficacy. contrast previous studies, show that most significantly affect all those MT-regulating function...
This paper describes the preparation of 3D polymer monoliths containing internal hierarchical porosity. The porous networks are fabricated based on Pickering high-internal-phase emulsions (HIPEs) stabilized by microporous β-cyclodextrin-based particles (CDPs) as emulsifier; CDPs facilely synthesized polyaddition reactions without need for catalysts. designed agents enable to form a bicontinuous phase in 8:2 cyclohexane-water v/v, and oil droplets continuous water is found be fairly stable up...
The roles of miRNAs in lung cancer have not yet been explored systematically at the genome scale despite their important regulatory functions. Here, we report an integrative analysis miRNA and mRNA sequencing data for matched tumor-normal samples from 109 Korean female patients with non-small-cell adenocarcinoma (LUAD). We produced (miRNA-Seq) RNA-Seq 48 61 additional patients. Subsequent differential expression stringent criteria yielded 44 2322 genes. Integrative gene set differentially...
The opportunistic pathogen V. parahaemolyticus is a major causative agent for seafood-borne illness worldwide. It also causes severe vibriosis in aquaculture animals, affecting seafood production with huge economic loss. These issues are getting worse due to the current global warming oceans, spread of antibiotic resistance, and changes consumer preference toward ready-to-eat (RTE) food items including seafood. To answer urgent need sustainable biocontrol agents against parahaemolyticus, we...
The comorbid association of autoimmune diseases with cancers has been a major obstacle to successful anti-cancer treatment. Cancer survival rate decreases significantly in patients preexisting autoimmunity. However, date, the molecular and cellular profiles such comorbidities are poorly understood. We used Aicardi-Goutières syndrome (AGS) as model disease explored underlying mechanisms genome instability AGS-associated-gene-deficient patient cells. found that R-loops highly enriched at...
Acute myeloid leukemia (AML) generally has an unsatisfactory prognosis despite the recent introduction of new regimens, including targeted agents and antibodies. To find a druggable pathway, we performed integrated bioinformatic pathway screening on large OHSU MILE AML databases, discovered SUMOylation validated it independently with external data set (totaling 2959 642 normal sample data). The clinical relevance in was supported by its core gene expression which is correlated patient...
Abstract An RNA structure or modified sequences can provide a platform for ribosome loading and internal translation initiation. The functional significance of has recently been highlighted by the discovery that subset circular RNAs (circRNAs) is internally translated. However, molecular mechanisms underlying initiation in circRNAs remain unclear. Here, we identify eIF3g (a subunit eIF3 complex) as binding partner eIF4A3, core component exon-junction complex (EJC) deposited onto spliced...
Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment, yet roles and mechanisms of TAMs inflammation-associated oncogenesis remain enigmatic. We report that protein canopy homolog 2 (CNPY2) functions as novel TLR4 regulator, promoting cytokine production macrophages. CNPY2 binds directly to TLR4. Cnpy2 deficiency reduces cell surface expression TLR4, nuclear translocation NFκB Macrophage-specific significantly decreases hepatocarcinogenesis diethylnitrosamine...
The global regulator Mlc is a repressor of several genes and operons that are involved in sugar uptake metabolism. A Salmonella enterica serovar Typhimurium mlc mutant showed reduced levels invasion cytotoxicity compared to the wild-type, exhibited expression hilD, hilA invF, which regulatory pathogenicity island 1 (SPI1). However, effects on hilD bacterial invasiveness were not seen hilE mutant, was increased suggests exerts positive SPI1 by reducing HilE, known down-regulate through direct...
Abstract Dysbiosis of the sinus microbiome affects pathophysiology chronic rhinosinusitis with nasal polyps (CRSwNPs). We investigated whether microbiota in CRSwNPs is associated eosinophilic inflammation, especially relation to innate lymphoid cells (ILCs), prognosis, and serum extracellular vesicles (EVs). Middle meatal swabs from 31 patients six healthy controls were analyzed by 16S ribosomal RNA sequencing. ILC2s cytokines sinonasal tissues measured flow cytometry ELISA, respectively....
Gut microbiome can affect drug metabolism considerably, leading to modified response. However, quantitative estimation of host vs. microbial contributions in a living host–gut system has been challenging. Using the interspecies Caenorhabditis elegans and gut bacteria, we developed real-time approach for monitoring their metabolic interaction vivo during anticancer 5-fluorouracil (5-FU) metabolism. The fluorine NMR-based yielded 5-FU made by human gut-microbial species variable genetic...
Abstract Backgroud and Aims Abnormalities in the tumor protein P53 ( p53 ) gene overexpression of mouse double minute 2 homolog (MDM2), a negative regulator p53, are commonly observed cancers. destabilization is regulated by endoplasmic reticulum (ER) stress unfolded response (UPR) cancer. However, mechanisms remain enigmatic. Canopy (CNPY2) key UPR initiator that primarily involved ER highly expressed liver, but its functional role regulating liver carcinogenesis poorly understood....
Astaxanthin (AST) exhibits potent antioxidant and anti-inflammatory activities but poor stability biological efficacy, which limit its application in the food medical industries. In present study, a new strategy was proposed to enhance of AST using fetal bovine serum-derived extracellular vesicles (EVs). Saponin-assisted incubation used load owing high encapsulation efficiency loading capacity. AST-incorporated EVs (EV-ASTs) maintained their original EV morphology showed at 4 °C, 25 37 °C...
Uncovering tumor markers of colorectal cancer is important for the early detection and prognosis patients. Spermine oxidase (SMOX) upregulated in various cancers. The present study aims to explore biologic function expression patterns SMOX (CRC), third most common type worldwide. We used quantitative real-time PCR, Western blot, vitro functional studies four CRC cell lines knocked down by siRNA immunohistochemistry 350 cases tissues. results showed that was overexpressed clinical samples....
Expansion microscopy (ExM) enhances spatial resolution by using a swellable polymer that expands the sample volume factor of ≈4 in one dimension and ≈64 volume. Combining ExM with stimulated emission depletion (STED) microscopy, referred to as ExSTED, increases up 10 nm. However, photobleaching is critical issue ExSTED because expansion lowers fluorophore density whereas high-resolution STED requires high intensity. To overcome these issues, we developed extremely bright nanoscopy...