A5100369170- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Cancer Research and Treatments
- Alcohol Consumption and Health Effects
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Colorectal Cancer Treatments and Studies
- Heat shock proteins research
- Cancer, Lipids, and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Single-cell and spatial transcriptomics
- RNA regulation and disease
- Inflammation biomarkers and pathways
- Anorectal Disease Treatments and Outcomes
- Microtubule and mitosis dynamics
The Ohio State University
2025
Shandong University
2018-2024
Shandong Provincial Hospital
2018-2024
Shandong First Medical University
2024
Affiliated Hospital of Jining Medical University
2015-2023
The Ohio State University Wexner Medical Center
2022
Beijing Friendship Hospital
2022
Capital Medical University
2022
Jining Medical University
2015-2021
MUSC Hollings Cancer Center
2014-2019
748 Background: Metastatic neuroendocrine bladder cancer is a rare and aggressive malignancy characterized by poor prognosis limited effective treatment options. Standard chemotherapy has shown success, necessitating novel therapies. We hypothesized that adding immunotherapy to would improve overall survival (OS) in these patients. Methods: conducted retrospective cohort study of 1,410 patients diagnosed with metastatic between 2004 2020 using the National Cancer Database (NCDB). Treatment...
Sepsis is a leading cause of death, which characterized by uncontrolled inflammatory response. In this study, we report that caveolin-1, major component caveolae, critical survival factor sepsis. We induced sepsis using well established animal model, cecal ligation and puncture (CLP). CLP 67% fatality in caveolin-1 null mice, but only 27% wild type littermates (<i>p</i> = 0.015). Further studies revealed mice deficient exhibited marked increase tumor necrosis factor-α interleukin-6...
Dysregulation of macrophage has been demonstrated to contribute aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, cell survival. In the present study, we explored effect leukadherin-1 (LA1), an agonist LPS-induced pro-inflammatory response macrophages endotoxic shock. Intriguingly, found that LA1 could significantly reduce mortalities mice alleviated pathological injury liver lung vivo...
Activation of TLR7 and TLR9 by endogenous RNA- or DNA-containing ligands, respectively, can lead to hyper-activation immune cells, including macrophages DCs, subsequently contributes the pathogenesis SLE. CD180, a TLR-like protein, has been shown participate in development activation cells. Our previous study others have reported that CD180-negative B cells are dramatically increased SLE patients responsible for production auto-antibodies. However, mode CD180 expression on DCs remains...
Cells and tissues, such as macrophages, express inducible nitric oxide synthase (INOS) after stimulation by certain factors. INOS helps mediate the macrophage inflammatory reaction, but few studies have explored how affects function in nonalcoholic fatty liver disease (NAFLD).
Abstract Backgroud and Aims Abnormalities in the tumor protein P53 ( p53 ) gene overexpression of mouse double minute 2 homolog (MDM2), a negative regulator p53, are commonly observed cancers. destabilization is regulated by endoplasmic reticulum (ER) stress unfolded response (UPR) cancer. However, mechanisms remain enigmatic. Canopy (CNPY2) key UPR initiator that primarily involved ER highly expressed liver, but its functional role regulating liver carcinogenesis poorly understood....
Intense efforts have been made in colorectal cancer (CRC) treatment recent decades. However, the mechanism of development and metastasis CRC has not fully cleared. This study is designed to identify key proteins involved stage III hepatic metastatic CRC.Protein expression profiles paired tumor benign tissue samples from patients are characterized by using a label-free proteomics approach. Key relevant revealed weighted gene correlation network analysis (WGCNA) other bioinformatics...
Objective Leucine-rich-repeat-containing G-protein-coupled receptor 5 (lgr5) is a candidate marker for colorectal cancer stem cells (CSC). In the current study, we investigated methylation status within thelgr5 promoter and evaluated its relationship with CSC differentiation, prognosis cancer, clinicopathological features. Methods The Lgr5 was detected methylation-specific PCR in six cell lines as well 169 primary tumor tissues. Differentiation of examined immunofluorescence...
Abstract Introduction Acute liver inflammatory reactions contribute to many health problems; thus, it is critical understand the underlying pathogenic mechanisms of acute hepatitis. In this study, an experimental in vivo model concanavalin A (ConA)‐induced hepatitis was used. Materials and Methods C57BL/6 (wild‐type, WT) or inducible nitric oxide synthase‐deficient (iNOS − /− ) mice were injected with PBS 15 mg/kg ConA via tail vein. Detection injury by histological examination apoptosis,...
Acute liver failure (ALF) is a serious threat to the life of people all over world. Finding an effective way manage ALF important. Human stem cells (HLSCs) are early undifferentiated that have been implicated in regeneration and functional reconstruction liver. In this study, we aimed evaluate protective effects HLSC line HYX1 against concanavalin A (ConA)-induced acute injury. were characterized by microscopy, assays, gene expression, western blot analyses. We showed can differentiate into...
Obesity is linked to nonalcoholic steatohepatitis. Peroxisome proliferator-activated receptor-α (PPARα) regulates lipid metabolism. Cytochrome P-450 2A5 (CYP2A5) a potential antioxidant and CYP2A5 induction by ethanol CYP2E1 dependent. High-fat diet (HFD)-induced obesity steatosis are more severe in knockout (cyp2a5-/-) mice than wild-type although PPARα elevated cyp2a5-/- mice. To examine why the upregulated failed prevent enhanced mice, we abrogate cross-breeding with (pparα-/-) create...
It is unclear how tumor-associated macrophages (TAMs) contribute to the initiation of oncogenesis and they are regulated at molecular level. By using a lineage-specific deletion strategy, we found that heat shock protein 90kDa β (Grp94), member 1 (HSP90B1), master chaperone for Toll-like receptors integrins also known as GP96, critically endows TAMs with ability promote genotoxic stress colitis-associated colon cancer.
Gastric cancer is among the most common malignant tumors of digestive tract. Establishing a robust and reliable animal model foundation for studying pathogenesis cancer. The present study established mouse gastric carcinoma by inoculating immunocompetent mice with MKN45 cells using microcarrier. Sixty male C57BL/6 were randomly divided into three groups: 2D group, an empty carrier 3D according to coculture system models hypodermic injection. Time develop tumor, rate tumor formation,...
This study aims to assess the prognostic implications of gene signature tertiary lymphoid structures (TLSs) in head and neck squamous cell carcinoma (HNSCC) scrutinize influence TLS on immune infiltration.
Scavenger receptor class B type I (SR-BI), a well-documented high-density lipoprotein receptor, has been implicated in the development and progression of human cancer. However, little is known regarding expression profile clinical value SR-BI gastric adenocarcinoma. In present study immunohistochemistry analysis was performed on well-annotated adenocarcinoma tissue microarray to investigate association between clinicopathological parameters or patient outcome. The results revealed that...
Objective: To investigate the protective effect of intraperitoneal transplantation human liver-derived stem cells at different times against concanavalin A (ConA)-induced acute liver injury in mice. Methods: total 88 male C57BL/6 mice were randomly divided into normal control group (group C), ConA model M), and (HYX1)+ConA E); according to interval between phosphate buffer/HYX1 injection injection, Groups M E further 3-hour groups (M1 E1 groups), 6-hour (M2 E2 12-hour (M3 E3 24-hour (M4 E4...
ABSTRACT Hepatocellular carcinoma (HCC) is one of the most common malignant tumors that threaten human health; thus, establishment an animal model with clinical features similar to liver cancer important practical significance. Taking advantage novel microcarrier-6, HCC cells was injected into immunocompetent mice establish a patient-derived xenograft (PDX) model. Primary were isolated from fresh tissues, which subsequently co-cultured microcarrier-6 construct three-dimensional tumor cell...