A5008613763- Plant Molecular Biology Research
- Plant Reproductive Biology
- Soybean genetics and cultivation
- Advanced biosensing and bioanalysis techniques
- Plant tissue culture and regeneration
- Reproductive Biology and Fertility
- Plant nutrient uptake and metabolism
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Ovarian function and disorders
- Reproductive System and Pregnancy
- DNA Repair Mechanisms
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Renal and related cancers
- Genomics and Chromatin Dynamics
- Retinoids in leukemia and cellular processes
- Pineapple and bromelain studies
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Heat shock proteins research
- Biotin and Related Studies
China Agricultural University
2015-2025
Affiliated Hospital of Jining Medical University
2013-2024
Genecast (China)
2022-2024
Beijing National Laboratory for Molecular Sciences
2019-2024
Peking University
2019-2024
Swedish University of Agricultural Sciences
2021-2023
Hewlett-Packard (United States)
2023
Dalian Medical University
2022
Uppsala University
2022
Fujian Agriculture and Forestry University
2014-2021
Age-related gastrointestinal decline contributes to whole-organism frailty and mortality. Genistein is known have beneficial effects on age-related diseases, but its precise role in homeostasis of the aging gut remains be elucidated. Here, wild-type mice Zmpste24-/- progeroid were used investigate genistein lifespan mammals. A series longitudinal, clinically relevant measurements performed evaluate effect healthspan. It was found that dietary promoted a healthier longer life associated with...
Soybean, a major legume crop native to East Asia, presents wealth of resources for utilization. The basic leucine zipper (bZIP) transcription factors play important roles in various biological processes including developmental regulation and responses environmental stress stimuli. Currently, little information is available regarding the bZIP family soybean.Using genome-wide domain analysis, we identified 160 GmbZIP genes soybean genome, named from GmbZIP1 GmbZIP160. These 160GmbZIP genes,...
Summary The accumulation of anthocyanins in response to specific developmental cues or environmental conditions plays a vital role plant development and protection against stresses. Extensive research has examined the regulation anthocyanin biosynthetic genes at transcriptional post‐transcriptional levels, but chromatin this remains unknown. Chromatin immunoprecipitation quantitative reverse transcription‐polymerase chain reaction ( qRT ‐ PCR ) analyses were performed. Genetic interactions...
In flowering plants, meiocytes develop from subepidermal cells in anthers and ovules. The mechanisms that integrate gene-regulatory processes with meiotic programs during reproductive development remain poorly characterized. Here, we show Arabidopsis thaliana plants deficient ACTIN-RELATED PROTEIN6 (ARP6), a subunit of the SWR1 ATP-dependent chromatin-remodeling complex, exhibit defects prophase I female meiosis. We found this defect is likely due to dysregulated expression genes,...
Pineapple (Ananas comosus L.) cultivation commonly relies on asexual reproduction which is easily impeded by many factors in agriculture production. Sexual might be a novel approach to improve the pineapple planting. However, genes controlling sexual are still remain elusive. In different organisms conserved superfamily proteins known as ATP binding cassette (ABC) participate various biological processes. Whereas, till today ABC gene family has not been identified pineapple. Here 100 were...
Germ-line specification is essential for sexual reproduction. In the ovules of most flowering plants, only a single hypodermal cell enlarges and differentiates into megaspore mother (MMC), founder female germ-line lineage. The molecular mechanisms restricting MMC to remain elusive. We show that Arabidopsis transcription factor WRKY28 exclusively expressed in somatic cells surrounding required repress these from acquiring MMC-like identity. this process, SWR1 chromatin remodeling complex...
Flowering plants display a remarkable diversity in inflorescence architecture, and pedicel length is one of the key contributors to this diversity. In Arabidopsis thaliana, receptor-like kinase ERECTA (ER) mediated signaling pathway plays important roles regulating architecture by promoting cell proliferation. However, mechanism remains elusive pedicel. Genetic interactions between chromatin remodeling complex SWR1 control were studied. Comparative transcriptome analysis was applied identify...
An efficient transformation protocol is a primary requisite to study and utilize the genetic potential of any plant species. A quick system also crucial for functional analysis genes along with proteins their interactions in vivo. Presently, however, effective systems are still lacking many species including pineapple. This has limited full exploration repository pineapple as well its genes, protein localization interactions. To address above limitations, we have developed an protoplast...
In most plants, the female germline starts with differentiation of one megaspore mother cell (MMC) in each ovule that produces four megaspores through meiosis, which survives to become functional (FM). The FM further develops into an embryo sac. Little is known regarding control MMC formation per and selective survival FM. ICK/KRPs (interactor/inhibitor cyclin-dependent kinase (CDK)/Kip-related proteins) are plant CDK inhibitors cycle regulators. Here we report ovules Arabidopsis mutant all...
In female mammals, the size of initially established primordial follicle (PF) pool within ovaries determines reproductive lifespan females. Interestingly, establishment PF is accompanied by a remarkable programmed oocyte loss for unclear reasons. Although apoptosis and autophagy are involved in process loss, underlying mechanisms require substantial study. Here, we identify new role lysine-specific demethylase 1 (LSD1) controlling fate oocytes perinatal mice through regulating level...
In female mammals, the majority of primordial follicles (PFs) are physiologically quiescent, and only a few them activated enter growing follicle pool. Specific molecules, such as mammalian target rapamycin (mTOR) serine/threonine kinase Akt (AKT), have been proven to be important for PF activation. However, how transcription these genes is regulated not clear. Although activators mTOR or AKT successfully used rescue fertility patients with premature ovarian insufficiency, low efficacy...
Primordial follicle pool established perinatally is a non-renewable resource which determines the female fecundity in mammals. While majority of primordial follicles maintain dormant state, only few them are activated into growing adults each cycle. Excessive activation accelerates consumption and leads to premature ovarian failure. Although previous studies including ours have emphasized importance keeping balance between dormancy via molecules within follicles, such as TGF-β, E-Cadherin,...
Abstract Multicellular organisms result from complex developmental processes largely orchestrated through the quantitative spatiotemporal regulation of gene expression. Yet, obtaining absolute counts messenger RNAs at a three-dimensional resolution remains challenging, especially in plants, owing to high levels tissue autofluorescence that prevent detection diffraction-limited fluorescent spots. In situ hybridization methods based on amplification cycles have recently emerged, but they are...
<title>Abstract</title> <bold>Background: </bold>Intestinal inflammation is an energy-consuming process that may alter energy supply and demand in poultry. During inflammation, the intestinal metabolic profile patterns of partitioning remain unclear. This study investigated effects on intake, heat production (HP), retained (RE) metabolites layer pullets. <bold>Methods: </bold>After 7 d dietary adaption, thirty-two “Jing Tint 6” pullets with average body weight (1,123.50 g ± 8.55) were...
Summary Megasporogenesis is essential for female fertility, and requires the accomplishment of meiosis formation functional megaspores. The inaccessibility low abundance meiocytes make it particularly difficult to elucidate molecular basis underlying megasporogenesis. We used high‐throughput tag‐sequencing analysis identify genes expressed in ( FM s) by comparing gene expression profiles from wild‐type ovules undergoing megasporogenesis with those spl mutant ovules, which lack A total 862...
Abstract The size of the primordial follicle pool determines reproductive potential mammalian females and establishment is highly dependent on specific genes expression. However, molecular mechanisms by which essential are regulated coordinately to ensure assembly remain a mystery. Here, we show that small GTPase Rac1 plays an indispensable role in controlling formation follicles mouse ovary. Employing fetal ovary organ culture system, demonstrate disruption retarded breakdown germline cell...
FIXa is a serine protease enzyme involved in the intrinsic pathway of coagulation cascade. The upstream intervention cascade selectively inhibiting would leave hemostasis intact via extrinsic pathway, leading to an optimum combination efficacy and safety with low incidence bleeding. We have identified 2-amindinobenzothiophene template as lead scaffold for inhibiton based on its homology urokinase plasminogen activator (uPA). Subsequent SAR work revealed number highly potent inhibitors,...
Angiosperm reproductive development is a complex event that includes floral organ development, male and female gametophyte formation interaction between the organs for successful fertilization. Previous studies have revealed redundant function of ATP binding cassette subfamily G (ABCG) transporters ABCG1 ABCG16 in pollen but whether they are involved other processes unknown. Here we show were not only expressed anthers stamen filaments also enriched pistil tissues, including stigma, style,...
Anticipatory grief has been shown to be highly prevalent among family caregivers of patients with advanced illness. Qualitative study suggests that illness uncertainty may one the core characteristics anticipatory grief, but it not confirmed in quantitative studies. Therefore, purpose this was explore relationship between and Chinese lung cancer determine factors influencing grief.This descriptive cross-sectional used a convenience sampling method recruited 254 inpatient from thoracic...
Although the predatory stress experimental protocol is considered more psychological than restraint protocol, it has rarely been used to study effect of on reproduction. Few studies exist direct a female developmental competence her oocytes, and maternal oocytes not reported. In this study, system was first established for mice with cats as predators. Beginning 24 h after injection equine chorionic gonadotropin, were subjected h. Evaluation mouse responses showed that we increased...