A5044462544- High voltage insulation and dielectric phenomena
- Cancer therapeutics and mechanisms
- Plant Molecular Biology Research
- Synthetic Organic Chemistry Methods
- Drug Transport and Resistance Mechanisms
- Plant Gene Expression Analysis
- Power Transformer Diagnostics and Insulation
- Blood Coagulation and Thrombosis Mechanisms
- Coordination Chemistry and Organometallics
- Protease and Inhibitor Mechanisms
- Berry genetics and cultivation research
- Microbial Metabolism and Applications
- Conducting polymers and applications
- Fungal Biology and Applications
- Food Quality and Safety Studies
- Synthesis and biological activity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phytochemicals and Antioxidant Activities
- Quinazolinone synthesis and applications
- Meat and Animal Product Quality
- Signaling Pathways in Disease
- Lightning and Electromagnetic Phenomena
- Perovskite Materials and Applications
- Plant biochemistry and biosynthesis
- Asymmetric Synthesis and Catalysis
Hubei Engineering University
2018-2025
Nanjing Medical University
2025
Nanjing University
2025
Nanjing General Hospital of Nanjing Military Command
2025
Harbin University of Science and Technology
2022-2023
Guangdong University of Technology
2022
AviChina Industry & Technology (China)
2022
Orion Corporation (Finland)
2022
University of Cambridge
2022
Shenyang Agricultural University
2017-2018
A series of substituted angular benzophenazines were prepared using a new synthetic route via novel regiocontrolled condensation 1,2-naphthoquinones and 2,3-diaminobenzoic acids. The synthesis biological activity this 8,9-benzo[a]phenazine carboxamide systems are described. analogues evaluated against the H69 parental human small cell lung carcinoma line H69/LX4 resistant which overexpresses P-glycoprotein. Selected COR-L23 non COR-L23/R multidrug resistance protein. This potent cytotoxic...
Multidrug resistance mediated by P-glycoprotein (Pgp) or multidrug-resistance-associated protein (MRP) remains a major obstacle for successful treatment of cancer. Inhibition Pgp and MRP transport is important high efficacy anticancer drugs. While several inhibitors have entered clinical trials, the development specific MRP1 still in its infancy. In our screening program, we identified pyrrolopyrimidine (4) as novel selective inhibitor. Subsequent SAR work on 4-position template revealed...
Real-time quantitative reverse transcription PCR (RT-qPCR) is one of the most effective tools for studying gene expression. Inonotus obliquus a rare and edible medicinal fungus. Selecting an appropriate reference crucial researching its function. In this study, we selected 11 potential genes . Subsequently, applied GeNorm, NormFinder, BestKeeper algorithms to evaluate expression stability these genes. Under varying carbon sources, VPS exhibited good was suitable as internal gene. different...
FIXa is a serine protease enzyme involved in the intrinsic pathway of coagulation cascade. The upstream intervention cascade selectively inhibiting would leave hemostasis intact via extrinsic pathway, leading to an optimum combination efficacy and safety with low incidence bleeding. We have identified 2-amindinobenzothiophene template as lead scaffold for inhibiton based on its homology urokinase plasminogen activator (uPA). Subsequent SAR work revealed number highly potent inhibitors,...
Circadian clocks coordinate physiology and development as an adaption to the oscillating day/night cycle caused by rotation of Earth on its axis changing length day night away from equator orbiting sun. confer advantages entraining rhythmic environmental cycles ensure that internal events within plant occur at correct time with respect cyclic external environment. Advances in determining structure circadian oscillators pathways allow them respond light, temperature, metabolic signals have...
In our continued effort to identify selective MRP1 modulators, we have developed two novel templates, 3 and 4, through rational drug design by identifying the key pharmacophore interaction at 7-position of pyrrolopyrimidine template 1. Further synthesis SAR work on these templates gave a number potent modulators with great selectivity against Pgp. Additional studies reduce CYP3A4 inhibition are also reported. Several compounds classes were subjected in vivo xenograft efficacies demonstrated.
On the basis of our understanding on binding interactions benzothiophene template within FIXa active site by X-ray crystallography and molecular modeling studies, we developed SAR strategy targeting 4-position to access S1 β S2−S4 sites. A number highly selective potent factor Xa (FXa) inhibitors were identified simple switch functional groups with conformational changes toward
Genes controlling fruit appearance determine shape and size. In ethylmethane sulfonate (EMS)-mutagenized lines of Fragaria vesca accession Yellow Wonder (YW), two shapes are observed: wild-type long mutated shortened (sf). this study, we first characterized sf based on morphology, histology, cytology physiology. The was identified as a gibberellin (GA)-deficient mutant, four complementary DNA (cDNA) libraries separately constructed from flower buds small green fruits YW were sequenced to...
The ingot of S31254 super austenitic stainless steel (SASS) was annealed at 1220 °C for 70 h to eliminate the segregation Mo element, and grain size grows level millimeter. stress–strain response microstructural evolution coarse-grained SASS were investigated by hot compression tests in temperature range 950–1250 strain rate 0.001–10 s−1. results showed that energy required plastic deformation improved with increase decrease temperature. activation calculated be 542.91 kJ·mol−1 through...