A5100613919- Plant Stress Responses and Tolerance
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
- Selenium in Biological Systems
- Multimodal Machine Learning Applications
- Bladder and Urothelial Cancer Treatments
- Plant pathogens and resistance mechanisms
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Plant Virus Research Studies
- Legume Nitrogen Fixing Symbiosis
- Chromatin Remodeling and Cancer
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Cancer-related gene regulation
- RNA modifications and cancer
- Tannin, Tannase and Anticancer Activities
- Advanced Neuroimaging Techniques and Applications
- Greenhouse Technology and Climate Control
- Berry genetics and cultivation research
- Gut microbiota and health
Second Affiliated Hospital of Shantou University Medical College
2022-2025
Shantou University
2022-2025
Southern Medical University
2023-2025
Hangzhou Medical College
2025
International Sakharov Environmental Institute
2025
Belarusian State University
2025
Ministry of Agriculture and Rural Affairs
2022-2024
Shanxi Datong University
2018-2024
Qilu Hospital of Shandong University
2024
National Clinical Research Center for Digestive Diseases
2024
Abstract Objective Bladder cancer(BCa) was a disease that seriously affects patients’ quality of life and prognosis. To address this issue, many researches suggested the gut microbiota modulated tumor response to treatment; however, had not been well-characterized in bladder cancer. In study, our objective determine whether diversity composition or density specific bacterial genera influence prognosis patients with Methods We collected fecal samples from total 50 cancer 22 matched non-cancer...
The integration of visual encoders and large language models (LLMs) has driven recent progress in multimodal (MLLMs). However, the scarcity high-quality instruction-tuning data for vision-language tasks remains a challenge. current leading paradigm, such as LLaVA, relies on language-only GPT-4 to generate data, which requires pre-annotated image captions detection bounding boxes, suffering from understanding details. A practical solution this problem would be utilize available instruction...
Schizochytrium sp. ATCC 20888 is an important species for industrial polyunsaturated fatty acids (PUFA) production. This study investigated the regulatory mechanisms affecting proportions of eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) in terms biosynthesis storage distribution. EPA DHA possessed different accumulation patterns: proportion increased over time, while peaked at 48 h. was predominantly integrated into triacylglycerol during logarithmic phase phosphatidylcholine...
MIR210HG is a novel long noncoding RNA (lncRNA) and has been found to be overexpresed in osteosarcoma glioma. However, the level of its clinical significance hepatocellular carcinoma (HCC) are not well known. In results our research, expression was increased HCC tissue samples cells compared with paired adjacent normal liver cell line respectively, good marker discriminate tissues from non-tumorous tissues. high-expression correlated advanced stage, big tumor size, present vascular invasion...
Ovarian cancer (OC) is a fatal in women, mainly due to its aggressive nature and poor survival rate. The lncRNA-miRNA-mRNA (long noncoding RNA-microRNA-messenger RNA) interaction promising biomarkers for the improving prognosis of OC. Therefore, we explored regulatory mechanism WDFY3-AS2/miR-18a/RORA axis involved biological activities OC cells. Microarray analysis predicted differentially expressed lncRNA, miRNA, mRNA related OC, followed by investigating relationship among them. expression...
Fragaria vesca (2n = 2x 14), the woodland strawberry, is a perennial herbaceous plant with small sequenced genome (240 Mb). It commonly used as genetic model for genus and Rosaceae family. Fruit skin color one of most important traits both commercial esthetic value strawberry. Anthocyanins are prominent pigments in strawberry that bring red, pink, white, yellow hues to fruits which they accumulate. In this study, we conducted de novo assembly fruit transcriptome compared gene expression...
Abstract The methyltransferase Polycomb Repressive Complex 2 (PRC2), composed of EZH2, SUZ12, and EED subunits, is associated with transcriptional repression via tri-methylation histone H3 on lysine 27 residue (H3K27me3). PRC2 a valid drug target, as the EZH2 gain-of-function mutations identified in patient samples drive tumorigenesis. inhibitors have been discovered demonstrated anti-cancer efficacy clinic. However, their pharmacological mechanisms are poorly understood. MAK683 potent...
The structure-activity relationship between digestion of walnut peptide (<3 kDa) and antioxidant activity were explored, the inhibitory effect DPP-IV on KGHLFPN (Lys-Gly-His-Leu-Phe-Pro-Asn) was selected. After simulated gastrointestinal digestion, peptides' capacities enhanced, tertiary structures weaker, secondary random coiled. C–H phylyl bonds broken macromolecular proteins hydrolyzed. Antioxidant a good inhibitor. And 4–8 h may be optimal time for oral absorption in vivo. Therefore,...
This paper presents OmniCity, a new dataset for omnipotent city understanding from multi-level and multi-view images. More precisely, OmniCity contains satellite images as well street-level panorama mono-view images, constituting over 100K pixel-wise annotated that are well-aligned collected 25K geo-locations in New York City. To alleviate the substantial annotation efforts, we propose an efficient street-viewimage pipeline leverages existing label maps of view transformation relations...
Understanding the spatial heterogeneity of light and photosynthesis distribution within a canopy is crucial for optimizing plant growth yield, especially in context greenhouse structures. In previous studies, we developed 3D functional-structural model (FSPM) Chinese solar (CSG) tomato plants, which was reconstructed as mockup implemented virtual scene. This model, accounts various environmental factors, allows precise calculations radiation, temperature, at organ level. study focuses on...
Cisplatin is a first generation platinum‑based chemotherapeutic agent, however, the extensive application of cisplatin inevitably results in drug resistance, which major obstacle cancer chemotherapy. The aim present study was to investigate efficiency reversing cisplatin‑resistance with use combination therapy oridonin and human ovarian cells, attempt reduce side effects therapeutic agents when used alone. half maximal inhibitory concentration (IC50) values were determined...
Abstract Aim This study investigated the role of RAP1B in hepatic lipid metabolism and its implications obesity associated metabolic disorders, focusing on molecular mechanisms through which influences accumulation, inflammation oxidative stress liver tissues hepatocyte cell lines. Materials Methods Liver‐specific RAP1B‐knockout (LKO) overexpression (OE) mice were generated fed a high‐fat diet for 18 weeks to evaluate systemic changes. Comprehensive phenotyping included measurements body...
Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic renal cell carcinoma (mRCC), but response rates remain heterogeneous, and reliable predictive biomarkers are lacking. Recent studies suggest that androgen receptor (AR) signaling plays a role in regulating CD8 + T-cell function, implying 5α-reductase (5-ARIs), which lower activity, could enhance antitumor immunity improve clinical outcomes patients receiving immunotherapy. This study...
This study aimed to investigate the diagnostic potential of diffusional kurtosis imaging (DKI) parameters in detecting pathological alterations normal-appearing white matter (NAWM) associated with cerebral small vessel disease (CSVD). A total 56 patients diagnosed CSVD were enrolled, all exhibiting confirmed lacunar infarction corticospinal tract (CST) as verified by conventional magnetic resonance imaging. control group 24 healthy individuals who exhibited no discernible abnormalities on...
CCCH (C3H) zinc-finger proteins are involved in plant biotic and abiotic stress responses, growth development, disease resistance. However, studies on C3H genes Phaseolus vulgaris L. (common bean) limited. Here, 29 protein-encoding genes, located 11 different chromosomes, were identified P. vulgaris. A phylogenetic analysis categorized the PvC3Hs into seven subfamilies basis of distinct features, such as exon-intron structure, cis-regulatory elements, MEME motifs. collinearity revealed...
Sugar Will Eventually be Exported Transporters (SWEET) proteins function as sugar transporters that play key roles in plant growth, development, and biotic abiotic stress responses. However, little is known about the SWEET gene family common bean (Phaseolus vulgaris L.). In this study, 24 putative PvSWEET genes were identified. They can categorized into four subgroups based on a phylogenetic analysis, exon–intron structure, cis-regulatory elements, MEME motifs. A collinearity analysis showed...