A5054364956- Selenium in Biological Systems
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Food Chemistry and Fat Analysis
- Cholinesterase and Neurodegenerative Diseases
- RNA modifications and cancer
- Enzyme Catalysis and Immobilization
- Moringa oleifera research and applications
- Lanthanide and Transition Metal Complexes
- MicroRNA in disease regulation
- Phytochemicals and Antioxidant Activities
- Organoselenium and organotellurium chemistry
- Protein Interaction Studies and Fluorescence Analysis
- Trace Elements in Health
- Circular RNAs in diseases
- Nanoparticles: synthesis and applications
Hubei University of Medicine
2025
Taihe Hospital
2025
Central South University
2015-2025
Wenzhou Medical University
2024
Dongyang People's Hospital
2024
Haikou City People's Hospital
2024
Jinan University
2011-2021
First Affiliated Hospital of Henan University of Science and Technology
2016-2021
First Affiliated Hospital of University of South China
2019
University of South China
2019
Multidrug-resistant (MDR) bacterial infections are a severe threat to public health owing their high risk of fatality. Noticeably, the premature degradation and undeveloped imaging ability antibiotics still remain challenging. Herein, selenium nanosystem in response bacteria-infected microenvironment is proposed as an antibiotic substitute detect inhibit methicillin-resistant Staphylococcus aureus (MRSA) with combined strategy. Using natural red blood cell membrane (RBCM) bacteria-responsive...
Alzheimer's disease (AD), the most common neurodegenerative disease, is caused by an accumulation of amyloid-β (Aβ) plaque deposits in brains. Evidence increasingly showing that epigallocatechin-3-gallate (EGCG) can partly protect cells from Aβ-mediated neurotoxicity inhibiting Aβ aggregation. In order to better understand process aggregation and amyloid fibril disaggregation reduce cytotoxicity EGCG at high doses, we attached onto surface selenium nanoparticles (EGCG@Se). Given low delivery...
Co-delivery of gene and drug therapies for cancer treatment remains a major goal nanocarrier research. In this study, mesoporous silica nanoparticles (MSNs) were used to co-deliver siRNA doxorubicin (Dox) redox-controlled release. The present (MSNs-SS-siRNA@Dox) has cores that can be loaded with Dox, while connects the core surface by disulfide linkage plays gatekeeper role. Disulfide linkages also utilized target intracellular GSH, their cleavage led release Dox siRNA. Release was...
Angiogenesis is crucial for tumor growth. Thus, inhibiting angiogenesis represents a promising avenue preventing This study investigated the anti-angiogenesis and anti-tumor effects of 8-hydroxyquinoline ruthenium(II) complexes [Ru(bpy)2(8-HQ)](+) (BQ) [Ru(phen)2(8-HQ)](+) (PQ). The results showed that both compounds, especially PQ, suppressed proliferation, migration, invasion, tube formation microvessel growth endothelial cells in vitro. PQ also inhibited human hepatocellular liver...
Functionalization can promote the uptake of nanoparticles into cancer cells via receptor-mediated endocytosis, enabling them to exert their therapeutic effects. In this paper, epigallocatechin gallate (EGCG), which has a high binding affinity 67 kDa laminin receptor (67LR) overexpressed in HCC cells, was employed present study functionalized ruthenium (RuNPs) loaded with luminescent complexes achieve antiliver efficacy. [Ru(bpy)2(4-B)] (ClO4)2·2H2O (RuBB)-loaded EGCG-RuNPs (bpy =...
The removal of copper from aqueous solutions using elemental selenium nanoparticles (nanoSe0) was presented. uptake by nanoSe0 depended on reducing agents, such as ascorbic acid (Vc) which reduced Cu(II) to Cu(I). results scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy dispersive (EDX) indicated that adsorbed interacting between cuprous ions form selenide (Cu2Se) the surface nanoSe0. effects mass nanoSe0, contact time, pH, initial concentration, temperature were...
Two ruthenium(ii) polypyridyl complexes [Ru(phen)2(4idip)](ClO4)2 (1) and [Ru(bpy)2(4idip)](ClO4)2 (2) (phen = 1,10-phenanthroline, bpy 2,2′-bipyridine, 4idip 4-indoleimidazo[4,5-f][1,10]phenanthroline) designed as telomeric G-quadruplex ligands have been synthesized characterized. The interaction of human DNA (HTG21) with the was explored by fluorescence analysis, absorption spectroscopy, continuous variation, circular dichroism resonance energy transfer (FRET) melting assay, polymerase...
Amyloid β (Aβ) aggregates are considered as possible targets for therapy of Alzheimer's disease (AD). Metal ions play an important role in amyloid aggregation and neurotoxicity the AD pathogenesis. Disruption interactions between these metal peptides holds considerable promise a therapeutic strategy treatment. In this study, L-Cys-modified Se/Ru nanoparticles (NPs) have been designed Aβ-binding units to inhibit metal-induced Aβ aggregation. L-Cys was used both reducing agent surface modifier...
Purpose: LncRNA MIR100HG promotes several types of malignancies, while its involvement in other human diseases is unknown. Patients and methods: Our study included 70 patients with LSCC who were diagnosed treated the First Affiliated Hospital College Clinical Medicine Henan University Science Technology from January 2016 to July 2018. qRT-PCR, cell transfection, vitro proliferation assay, migration invasion assay applied for research. Results: In present we found that was upregulated,...
Medium-long-medium (MLM) structured lipid (SL) as a new SL is potential functional ingredient in food and nutraceutical products, but its composition-structure-physicochemical properties relationship has not been revealed industry. MLM type of medium-long chain triacylglycerol (MLCT) was synthesized from Camellia oil by combi-lipase; physicochemical composition-structure were investigated this research. The higher MLCT (67.24% ± 0.09) (52.71% 0.53) productivities achieved after parameter...