A5078426957- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Ion Channels and Receptors
- Piperaceae Chemical and Biological Studies
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Bioactive Compounds and Antitumor Agents
- Eosinophilic Disorders and Syndromes
- Toxin Mechanisms and Immunotoxins
- Eicosanoids and Hypertension Pharmacology
- Mesenchymal stem cell research
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Bone Tissue Engineering Materials
- Endometrial and Cervical Cancer Treatments
- Mechanisms of cancer metastasis
Marshall University
2016-2025
Cabell Huntington Hospital
2018-2024
University of Mississippi Medical Center
2020
Jackson Memorial Hospital
2020
West Virginia University
2018
University of Mississippi
2018
Bidhan Chandra Krishi Viswavidyalaya
2017
Boston Children's Hospital
2017
Harvard University
2017
Cedars-Sinai Medical Center
2017
Therapy-resistant cancer stem cells (CSCs) contribute to the poor clinical outcomes of patients with recurrent glioblastoma (rGBM) who fail standard care (SOC) therapy. ChemoID is a clinically validated assay for identifying CSC-targeted cytotoxic therapies in solid tumors.In randomized trial (NCT03632135), assay, personalized approach selecting most effective treatment from FDA-approved chemotherapies, improves survival rGBM (2016 WHO classification) over physician-chosen chemotherapy. In...
Abstract Patients with recurrent platinum-resistant ovarian cancer ( PROC ) have poor clinical outcomes, owing mainly to the presence of therapy-resistant stem cells CSCs ). The NCT03949283 randomized trial enrolled patients receive ChemoID-guided chemotherapy or best physician-choice regimen selected from same list thirteen mono combination chemotherapies. primary outcome was objective response rate ORR assessed on CT scans using RECIST 1.1 criteria at 6 months follow-up. Subjects treated...
CCDC6 gene product is a pro-apoptotic protein substrate of ATM, whose loss or inactivation enhances tumour progression. In primary tumours, the impaired function has been ascribed to rearrangements and somatic mutations in several neoplasia. Recently, low levels protein, NSCLC, have correlated with tumor prognosis. However, mechanisms responsible for variable tumors not described yet.We show that turnover regulated cell cycle dependent manner. undergoes cyclic variation phosphorylated status...
The prognosis of glioblastoma (GBM) treated with standard-of-care maximal surgical resection and concurrent adjuvant temozolomide (TMZ)/radiotherapy remains very poor (less than 15 months). GBMs have been found to contain a small population cancer stem cells (CSCs) that contribute tumor propagation, maintenance, treatment resistance. highly invasive nature high-grade gliomas their inherent resistance therapy lead high rates recurrence. For these reasons, not all patients similar diagnoses...
Chemotherapy-resistant cancer stem cells (CSC) may lead to tumor recurrence in glioblastoma (GBM). The poor prognosis of this disease emphasizes the critical need for developing a treatment stratification system improve outcomes through personalized medicine.We present case series 12 GBM and 2 progressive anaplastic glioma cases from single Institution prospectively treated utilizing CSC chemotherapeutics assay (ChemoID) guided report. All patients were eligible receive stereotactic biopsy...
Administration of ineffective anticancer therapy is associated with unnecessary toxicity and development resistant clones. Cancer stem-like cells (CSLCs) resist chemotherapy, thereby causing relapse the disease. Thus, a test that identifies most effective chemotherapy management offers great promise for individualized treatments. We have developed an ex vivo sensitivity assay (ChemoID), which measures CSLCs as well bulk tumor to variety agents. Two patients, 21-year old male (patient 1)...
The repair of orthopedic and maxillofacial defects in modern medicine currently relies heavily on the use autograft, allograft, void fillers, or other structural material composites. This study examines vitro osteo regenerative potential polycaprolactone (PCL) tissue scaffolding, fabricated via a three-dimensional (3D) additive manufacturing technology, i.e., pneumatic micro extrusion (PME) process. objectives this were: (i) To examine innate osteoinductive osteoconductive 3D-printed PCL...
Acinic cell carcinoma (ACC) is an uncommon salivary gland neoplasm that generally displays indolent growth pattern. Most cases arise in the major glands, particularly parotid. However, it can from minor glands oral cavity and aero-digestive tract. Although ACC a low-grade malignant tumor, poorly differentiated high-grade transformed variants exhibit propensity for late recurrence metastasis. There are no adequate clinical trials define optimal approach to patients with metastatic tumors due...
Glioblastoma (GBM) is a lethal disease. At least in part, the recurrence of GBM caused by cancer stem cells (CSCs), which are resistant to chemotherapy. Personalized anticancer therapy against CSCs can improve treatment outcomes. We present prospective cohort study 40 real-world unmethylated Methyl-guanine-methyl-transferase-promoter patients treated utilizing CSC chemotherapeutics assay-guided report (ChemoID).Eligible who underwent surgical resection for recurrent were included study. Most...
Follicular dendritic cell tumor (FDCT) is an uncommon neoplasm that typically presents as a slow-growing, painless mass without systemic symptoms. Histologically, FDCT characterized proliferation of spindle to ovoid cells having plump eosinophilic cytoplasm with indistinct borders and nuclei vesicular or granular chromatin small distinct nucleoli. The immunohistochemical profile includes positive staining for CD21, CD23, CD35, vimentin, fascin, HLA-DR, epithelial membrane antigen, clusterin,...
Abstract COVID-19, caused by SARS-CoV-2, is associated with arterial and venous thrombosis, thereby increasing mortality. SARS-CoV-2 spike protein (SP), a viral envelope structural protein, implicated in COVID-19-associated thrombosis. However, the underlying mechanisms remain unknown. Thymidine phosphorylase (TYMP), newly identified prothrombotic upregulated plasma, platelets, lungs of patients COVID-19 but its role thrombosis not defined. In this study, we found that wild-type SP...
Obesity results in hepatic fat accumulation, i.e., steatosis. Besides the overload, impaired fatty acid β-oxidation also promotes Fatty takes place mitochondria and peroxisomes. Usually very long chain branched-chain acids are first oxidized peroxisomes, resultant short further mitochondria. Peroxisome biogenesis is regulated by peroxin 16 (PEX16). In liver-specific PEX16 knockout (Pex16Alb-Cre) mice, hepatocyte peroxisomes were absent, but hepatocytes proliferated, liver mass was...
Obesity is linked to nonalcoholic steatohepatitis. Peroxisome proliferator-activated receptor-α (PPARα) regulates lipid metabolism. Cytochrome P-450 2A5 (CYP2A5) a potential antioxidant and CYP2A5 induction by ethanol CYP2E1 dependent. High-fat diet (HFD)-induced obesity steatosis are more severe in knockout (cyp2a5-/-) mice than wild-type although PPARα elevated cyp2a5-/- mice. To examine why the upregulated failed prevent enhanced mice, we abrogate cross-breeding with (pparα-/-) create...