A5046896939- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Brain Metastases and Treatment
- Surgical site infection prevention
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Surgical Sutures and Adhesives
- Urologic and reproductive health conditions
- Peripheral Nerve Disorders
- Orthopedic Infections and Treatments
- Memory and Neural Mechanisms
- Pleural and Pulmonary Diseases
- Trauma Management and Diagnosis
- Traumatic Ocular and Foreign Body Injuries
- Vascular Malformations Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Congenital Diaphragmatic Hernia Studies
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
Marshall University
2013-2023
Neurological Surgery
1986-1987
Hunter Holmes McGuire VA Medical Center
1987
Virginia Commonwealth University Medical Center
1986-1987
✓ A consecutive series of 330 severely head-injured patients was studied prospectively. All the were treated with same protocols by physicians and staff in intensive care unit. had intracranial pressure (ICP) monitoring. Of patients, 100 pediatric age group (0 to 19 years age) 230 adult (20 80 age). Statistical analyses performed regard outcome, Glasgow Coma Scale (GCS) score, ICP course, incidence surgical lesions. The average emergency room GCS score as well 24-hour for each same....
Therapy-resistant cancer stem cells (CSCs) contribute to the poor clinical outcomes of patients with recurrent glioblastoma (rGBM) who fail standard care (SOC) therapy. ChemoID is a clinically validated assay for identifying CSC-targeted cytotoxic therapies in solid tumors.In randomized trial (NCT03632135), assay, personalized approach selecting most effective treatment from FDA-approved chemotherapies, improves survival rGBM (2016 WHO classification) over physician-chosen chemotherapy. In...
✓ Two cases of postoperative neurological deterioration following routine neurosurgical procedures are presented. In each instance, the patient was found to have hematological abnormalities present preoperatively consistent with vitamin B 12 deficiency and undergone general anesthesia involving N 2 O. This caused inactivation remaining marginal stores resultant decompensation. The frequent use O in significant incidence make it imperative that surgeon be aware this complication its easy...
The prognosis of glioblastoma (GBM) treated with standard-of-care maximal surgical resection and concurrent adjuvant temozolomide (TMZ)/radiotherapy remains very poor (less than 15 months). GBMs have been found to contain a small population cancer stem cells (CSCs) that contribute tumor propagation, maintenance, treatment resistance. highly invasive nature high-grade gliomas their inherent resistance therapy lead high rates recurrence. For these reasons, not all patients similar diagnoses...
Abstract A case of T-1, T-2 disc herniation is reported. The patient presented with diminished hand strength, medial arm and shoulder pain, arm, forearm, paresthesias. After surgical decompression removal a fragment, the made complete recovery. Routine cervical myelography was considered inadequate in view this patient's symptoms. High thoracic followed by computed tomographic scanning should be for patients presentation. Improved diagnosis tomography discussed.
Administration of ineffective anticancer therapy is associated with unnecessary toxicity and development resistant clones. Cancer stem-like cells (CSLCs) resist chemotherapy, thereby causing relapse the disease. Thus, a test that identifies most effective chemotherapy management offers great promise for individualized treatments. We have developed an ex vivo sensitivity assay (ChemoID), which measures CSLCs as well bulk tumor to variety agents. Two patients, 21-year old male (patient 1)...
A series of 100 patients 19 years age or younger is presented. Age, mechanism injury, Glasgow coma score (GCS), diagnosis, outcome, and other factors arc analysed. Ninety-four per cent the had ICP monitoring, 68% a good moderately disabled outcome; that is, they were functioning. There was 24% mortality. 25% incidence mass lesion these did worse. The major cause death neurologic injury.
e13012 Background: Cancer stem-like cells (CSLCs) in primary brain tumors can resist certain chemotherapies, thereby causing relapse of the disease. Thus, development a test that identifies most effective chemotherapy management offers great promise for personalized anticancer treatments. Methods: We have developed an ex vivo chemosensitivity assay (ChemoID) designed to predict sensitivity and resistance CSLCs bulk tumor given patient's solid variety agents by measuring cellular viability...
e13028 Background: Glioblastoma multiforme (GBMs) are brain tumors with low survival rates due to the presence of chemoresistant Glioma Cancer Stem-Like Cells (GCSLCs). Development a test that identifies most effective chemotherapy management for GCSLCs offers great promise personalized anticancer treatments. Methods: We have developed drug response assay (ChemoID) designed predict and bulk tumor cells given patient by measuring cell death following treatments at clinically relevant doses....
2089 Background: Cancer stem-like cells (CSLCs) in primary brain tumors can resist certain chemotherapies, thereby causing relapse of the disease. Thus, development a test that identifies most effective chemotherapy management offers great promise for personalized anticancer treatments. Methods: We have developed an ex vivo ChemoID assay designed to predict sensitivity and resistance CSLCs bulk tumor given patient's solid variety agents by measuring percentage cell death. In retrospective...
Abstract Patients with cervical spondylotic myelopathy who were neurosurgical candidates prospectively evaluated for voiding abnormalities. The patients had relatively advanced neurologic disease because of delays in presentation and diagnosis. 22 consecutive included 20 males 2 females average age 57 years. Sixteen symptoms 12 noting a change pattern following the onset their symptoms. Detrusor hyperreflexia was present 16 (73%) external sphincter dyssynergia 8 (36%) patients....
e13544 Background: We have developed a drug response assay (ChemoID) that identifies effective chemotherapy against cancer stem cells (CSCs) vs. bulk of tumor from panel potential treatments. A prospective study was conducted evaluating the use CSC in glioblastoma patients treated with standard-of-care. Methods: 41 were enrolled an IRB-approved protocol. Patients all standard-of-care TMZ plus radiation or without maximal surgery. prospectively monitored for response, time to recurrence,...
2028 Background: Clinical outcomes in patients with recurrent high-grade glioma (HGG) remain poor. Cancer stem cells (CSCs) have been implicated metastasis, treatment resistance and recurrence of HHGs. We shown several clinical studies that anti-CSC-directed therapy selected by ChemoID assay provides benefits many cancer types; however, this is the first report a randomized trial evaluating whether CSC-targeted cytotoxic agents assay-guided improves survival HGG. Methods: In parallel-group,...
Multiorgan Intra-thoracic herniation is a rare complication of traumatic diaphragmatic rupture that occurs in particular after vehicle accident. Because its specific clinical signs it can be misdiagnosed. We present case left with transthoracic migration stomach, splenic flexur colon, spleen, and pancreas tail, was successfully repaired primarily.
e13040 Background: Cancer stem-like cells (CSLCs) can resist certain chemotherapies, thereby causing relapse of the disease. Thus, development a test that identifies most effective chemotherapy management offers great promise for individualized anticancer treatments. Methods: We have developed ChemoID, an in vitro assay, designed to predict sensitivity and resistance given patient’s CSLCs bulk tumor variety agents. Results: A 5-month female (Patient A), 21-year old male B), both affected by...
2057 Background: Over the past 20 years even with aggressive standard of care (SoC) Stupp treatment protocol prognosis glioblastoma (GBM) has only minimally improved from 12 to 14 months. This is due in large part presence chemo- and radiation-resistant GBM cancer stem cells (CSCs) that contribute tumor propagation, maintenance, resistance. We are using ChemoID, a CLIA certified CAP accredited drug response assay identifies most effective chemotherapy against CSCs bulk panel potential...
Over the past 20 years even with aggressive standard of care (SoC) Stupp treatment protocol prognosis glioblastoma (GBM) has only minimally improved from 12 to 14 months. This is due in large part presence chemo- and radiation-resistant GBM cancer stem cells (CSCs) that contribute tumor propagation, maintenance, resistance. We are using ChemoID, a CLIA certified CAP accredited drug response assay identify most effective chemotherapy against CSCs bulk panel chemotherapies, offering great...
CT-guided stereotactic biopsy of lower brain stem lesions in 7 consecutive cases is discussed. A frontal transincisural approach was used. Five patients had astrocytomas histologically. The single patient who undergone empirical radiation therapy prior to tissue diagnosis revealed only necrosis. One found have pathology suggestive Leigh's disease. This not radiated and the first alive adult this confirmed. Although controversy still exists management lesions, we intend demonstrate value such lesions.
Abstract With the easily available option for surgeons to soak their suture in anti-biotic irrigating solution intraoperatively mind, this study was designed evaluate ability of soaked bacitracin inhibit growth Staphylococcus aureus and Methicillin-resistant . Using standard experimental procedure, sterile Bacitracin suture, dried 10 minutes or 6 hours, incubated 24 h on inoculated plates, examined zone inhibition around suture. This compared control unsoaked antimicrobial (AMS) currently...
Sedation is a ubiquitous practice in ICUs and NCCUs. It has the benefit of reducing cerebral energy demands, but also precludes an accurate neurologic assessment. Because this, sedation intermittently stopped for purposes assessment, which termed wake-up test (NWT). NWTs are considered to be gold-standard continued assessment brain-injured patients under sedation. produce acute stress response that accompanied by elevations blood pressure, respiratory rate, heart ICP. Utilization...