A5060406027- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Fatty Acid Research and Health
- Pituitary Gland Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Spinal Hematomas and Complications
- Growth Hormone and Insulin-like Growth Factors
- Intracranial Aneurysms: Treatment and Complications
- Infectious Diseases and Tuberculosis
- Cancer Research and Treatments
- Neurosurgical Procedures and Complications
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cellular transport and secretion
- Cholesterol and Lipid Metabolism
- Osteomyelitis and Bone Disorders Research
- Spinal Dysraphism and Malformations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Allegheny Health Network
2016-2020
Allegheny General Hospital
2014-2015
Massachusetts General Hospital
2007-2013
Harvard University
2007-2013
Harvard University Press
2012
University of Illinois Chicago
2002-2007
University of Illinois Urbana-Champaign
2002
Illinois College
2002
ω-3 Fatty acid (FA) emulsions reduce LPS-stimulated murine macrophage TNF-α production, but the exact mechanism has yet to be defined. The purpose of this study was determine for FA inhibition production following LPS stimulation. RAW 264.7 cells were pretreated with isocaloric (Omegaven), ω-6 (Lipovenos), or DMEM and subsequently exposed LPS. IκB-α phospho-IκB-α determined by Western blotting. NF-κB binding assessed using electromobility shift assay, activity measured a luciferase reporter...
Angiopoietin-1 (Ang1) exerts a vascular endothelial barrier protective effect by blocking the action of permeability-increasing mediators such as growth factor (VEGF) through unclear mechanisms. Because VEGF may signal hyperpermeability phospholipase C (PLC)-IP 3 pathway that activates extracellular Ca 2+ entry via plasmalemmal store-operated channel transient receptor potential canonical-1 (TRPC1), we addressed possibility Ang1 acts inhibiting this mechanism in cells. Studies cell...
Abstract NO is a crucial mediator of the inflammatory response, but its in vivo role as determinant lung inflammation remains unclear. We addressed regulating activation NF-κB and expression proteins using an mouse model sepsis induced by i.p. injection Escherichia coli. observed time-dependent degradation IκB accompanied increases inducible NOS, macrophage protein-2 (MIP-2), ICAM-1 after E. coli challenge, which paralleled ability tissue to produce high-output NO. To determine this process,...
Chemotherapy-resistant cancer stem cells (CSC) may lead to tumor recurrence in glioblastoma (GBM). The poor prognosis of this disease emphasizes the critical need for developing a treatment stratification system improve outcomes through personalized medicine.We present case series 12 GBM and 2 progressive anaplastic glioma cases from single Institution prospectively treated utilizing CSC chemotherapeutics assay (ChemoID) guided report. All patients were eligible receive stereotactic biopsy...
The authors evaluated the effectiveness of a simple technique using ethylene oxide (EtO) gas sterilization and room temperature storage autologous bone grafts for reconstructive cranioplasty following decompressive craniectomy. retrospectively analyzed data in 103 consecutive patients who underwent craniectomy any cause at University Illinois Chicago between 1999 2005. Patients with pre-existing intracranial infection prior to or lost follow-up before reconstruction were excluded. Autologous...
We examined the relationship between neutrophil [polymorphonuclear leukocyte (PMN)] influx and lung vascular injury in response to Escherichia coli pneumonia. assessed tissue PMN uptake by measuring myeloperoxidase transvascular migration determining counts interstitium bronchoalveolar lavage fluid (BALF) mice challenged intratracheally with E. coli. Lung was quantified microvessel filtration coefficient ( K f,c ), a measure of permeability. addressed role CD18 integrin mechanism inducing...
Objective: Spindle cell oncocytoma (SCO) is a rare neoplasm of the anterior pituitary that clinically and radiologically indistinguishable from nonfunctioning adenomas. The 26 cases reported to date presented with symptoms mass effect hypopituitarism. We describe previously unreported presentation SCO pituitary, severe hyponatremia.
A distinctive case of primary biliary lymphoma occurring in the cystic duct causing extrinsic compression porta hepatis a 48-year-old woman is presented. Imaging studies revealed stricture common hepatic with 2.5-cm nonhomogeneous mass at hepatis, mimicking Klatskin tumor. Exploratory laparotomy gallbladder neck extension into akin to Mirizzi's syndrome. soft, tan-yellow 1.0-cm was removed from duct, and infiltrating atypical lymphocytic nodules were identified final diagnosis an anaplastic...
Our in vivo and vitro studies using omega-3 fatty acids (FA) have provided insight into the biological effects mechanisms of their anti-inflammatory action(s). The implications for this research are profound because there few nutritional therapies available that potential to be clinically effective malignancies other chronic inflammatory conditions as FA. In summary experiments FA discussed action presented.
Acute pancreatitis is often complicated by multiorgan dysfunction, which postulated to occur in part macrophage infiltration into the pancreas. Eicosapentaenoic acid (EPA), an omega-3 fatty acid, principal biologic component of fish oil and has clinically experimentally been demonstrated be anti-inflammatory. We hypothesized that dietary EPA supplementation before induction would attenuate both M-mediated local pancreatic systemic pulmonary inflammatory response vivo model acute edematous...
The progressive refinement of transsphenoidal pituitary surgery has continued under a minimally invasive endoscopic strategy. physical advantages the endoscope allow approach through natural nasal air pathway without need for retractor. unique optical characteristics an provide great in tumor surgery, particularly macroadenomas. Wide-angled panoramic views at posterior wall sphenoidal sinus clear anatomic orientation comparison to limited sellar exposure conventional microscopic techniques....
Edited by Anil Nanda, 1st Edition, 2012. Published Thieme Medical Publishers, Inc., New York, pp 252 (hardcover). (Foreward Peter J Jannetta). ISBN: 978-1588906632 Having authored one of the chapters, we have been familiar with this project during its evolution. This well-organized book fills a niche as comprehensive but concise reference or vade mecum dedicated to unique neuroanatomical compartment posterior fossa. It is well known neurosurgeons that range disorders include trauma,...