A5030904160- Phytochemistry and Bioactive Compounds
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Phytochemical Studies and Bioactivities
- Ion Transport and Channel Regulation
- Hormonal Regulation and Hypertension
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Phytochemicals and Antioxidant Activities
- Alcohol Consumption and Health Effects
- Wound Healing and Treatments
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Fungal Biology and Applications
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects of Natural Compounds
- Microbial Metabolites in Food Biotechnology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac electrophysiology and arrhythmias
- Immunodeficiency and Autoimmune Disorders
- Pancreatic function and diabetes
- interferon and immune responses
- Skin Protection and Aging
- RNA regulation and disease
Northeast Agricultural University
2024
Marshall University
2016-2023
University of Toledo
2018-2021
China Pharmaceutical University
2014-2021
Jiangsu Food and Pharmaceutical Science College
2021
University of Florida
2019
Anhui Agricultural University
2019
Zhejiang Academy of Medical Sciences
2019
Gladstone Institutes
2019
Central South University
2017
Abstract Alzheimer’s disease (AD) is the most common cause of dementia. A finding in AD DNA damage. Double-strand breaks (DSBs) are particularly hazardous to neurons because their post-mitotic state forces rely on error-prone and potentially mutagenic mechanisms repair breaks. However, it remains unclear whether damage results from increased or failure repair. Oligomerization tumor suppressor protein p53 an essential part DSB repair, phosphorylated S15 indicator We report that monomer:dimer...
The Na/K-ATPase α1 polypeptide supports both ion-pumping and signaling functions. α3 differs from in its primary structure tissue distribution. expression of seems particularly important neurons, recent clinical evidence a unique role this isoform normal brain function. nature specific has remained elusive, because the ubiquitous presence hindered efforts to characterize α3-specific functions mammalian cell systems. Using knockdown pig kidney cells (PY-17), we generated first stable line...
The objective of this study was to investigate the potential
At concentrations found in humans after ingestion of one to two cups green tea, epicatechin-3-gallate (ECG) modulates Na/K-ATPase conformation and activity. Akin ouabain, an archetypal ligand the cardiotonic steroid (CTS) family, ECG also activates protein kinase C epsilon type (PKCε) translocation increases force contraction rat heart. This study evaluated whether, like Na/K-ATPase/Src receptor function triggers pre- postconditioning against ischemia/reperfusion (I/R) injury. In vitro,...
Ouabain preconditioning (OPC) initiated by low concentrations of the cardiac glycoside (CG) ouabain binding to Na/K-ATPase is relayed a unique intracellular signaling and protects myocytes against ischemia/reperfusion injury. To explore more clinically applicable protocols based on CG properties, we tested whether FDA-approved digoxin could trigger cardioprotective effects comparable with those using PC, PostC, postconditioning in Langendorff-perfused mouse heart subjected global ischemia...
Recent studies have revealed that Na/K-ATPase (NKA) can transmit signals through ion-pumping–independent activation of pathways relayed by distinct intracellular protein/lipid kinases, and endocytosis challenges the traditional definition cardiotonic steroids (CTS) are NKA inhibitors. Although additional effects CTS long been suspected, revealing its agonist impact receptor could be a novel mechanism in understanding basic biology NKA. In this study, we tested whether different structural...
The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in treatment of cardiac conditions, CTS inhibit ion-pumping function Na/K-ATPase. much lower concentrations, range those reported endogenous blood, they stimulate hypertrophic growth cultured myocytes through initiation a Na/K-ATPase-mediated reactive oxygen species (ROS)-dependent signaling. To examine possible effect on structure vivo, we compared mice...
AbstractA series of flavone glycosides were isolated from Fructus Kochiae for the first time, including two new glycosides. The structures established by interpretation their spectroscopic data. Two are quercetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranosyl-7-O-β-d-glucopyranoside (1) and 3-O-α-l-rhamnopyranosyl-(1 6)-β-d-galactopyranosyl-7-O-β-d-sophoroside (2). others 7-O-β-d-glucopyranoside (3), 2)-β-d-galactopyranoside (4), 3-O-β-d-galactopyranosyl-7-O-β-d-glucopyranoside (5),...
(1) Background: Cardiotonic steroids have been found to stimulate collagen synthesis and might be potential wound healing therapeutics. The objective of this study was evaluate the feasibility digitoxigenin its topical formulation for healing; (2) Methods: In in vitro study, human dermal fibroblast cells were treated with assessed. vivo applied excisional full-thickness wounds rats immediately after wounding remained three days, open evaluated over 10 days. A administration prepared, release...
The roots of six species Salvia (S. argentea, S. aerea, cavaleriei, constanea, trijuga and yunnanensis) have been examined for the presence diterpenoids. Diterpenoids were found in all except cavaleriei. Those extracted from yunnanenis very similar; tanshinone 1 2A isolated four, whereas cryptotanshinone dihydrotanshinone not detected extracts yunnanensis trijuga, respectively. Przewaquinones A B only constanea. diterpenoids argentea differed completely those other investigated;...