A5028364829- Nicotinic Acetylcholine Receptors Study
- Ion Channels and Receptors
- Lung Cancer Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Receptor Mechanisms and Signaling
- Piperaceae Chemical and Biological Studies
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Toxin Mechanisms and Immunotoxins
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- Bioactive Compounds and Antitumor Agents
- Bioactive natural compounds
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- Synthesis and biological activity
- Protein Kinase Regulation and GTPase Signaling
- Genomics and Chromatin Dynamics
- 14-3-3 protein interactions
- Pituitary Gland Disorders and Treatments
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related gene regulation
Marshall University
2015-2024
Moffitt Cancer Center
2003-2023
Texas Biomedical Research Institute
2023
University of Mississippi
2017
Bidhan Chandra Krishi Viswavidyalaya
2017
Boston Children's Hospital
2017
Harvard University
2017
Cedars-Sinai Medical Center
2017
National Institute of Technology Durgapur
2016
Alderson Broaddus University
2012
Abstract Cigarette smoking is strongly correlated with the onset of nonsmall cell lung cancer (NSCLC). Nicotine, an active component cigarettes, has been found to induce proliferation lines. In addition, nicotine can angiogenesis and confer resistance apoptosis. All these events are mediated through nicotinic acetylcholine receptors (nAChRs) on cells. this study, we demonstrate that promote anchorage‐independent growth in NSCLCs. also induces morphological changes characteristic a migratory,...
Prohibitin, a potential tumor suppressor protein, has been shown to inhibit cell proliferation and repress E2F transcriptional activity. Though prohibitin potent functions in the nucleus, mitochondrial role for also proposed. Here we show that is predominantly nuclear two breast cancer lines where it co-localizes with E2F1 p53. Upon apoptotic stimulation by camptothecin, exported perinuclear regions localizes mitochondria. The data presented here capable of physically interacting p53 vivo...
Recent studies have shown that nicotine, a component of cigarette smoke, can stimulate the proliferation non-neuronal cells. While nicotine is not carcinogenic by itself, it has been to induce cell and angiogenesis. Here we find mitogenic effects in non-small lung cancers (NSCLCs) are analogous those growth factors involve activation Src, induction Rb-Raf-1 interaction, phosphorylation Rb. Analysis human NSCLC tumors show enhanced levels complexes compared with adjacent normal tissue. The...
Non-small cell lung cancer (NSCLC) demonstrates a strong etiologic association with smoking. Although nicotine is not carcinogenic, it can induce proliferation and angiogenesis suppress apoptosis induced by certain agents. Here we show that inhibits the drugs gemcitabine, cisplatin, taxol, which are used to treat NSCLCs. This protection correlated induction of XIAP survivin in panel human NSCLC lines, depletion ablated protective effects nicotine. The antiapoptotic were mediated dihydro...
Proponents for electronic cigarettes (E-cigs) claim that they are a safe alternative to tobacco-based cigarettes; however, little is known about the long-term effects of exposure E-cig vapor on vascular function. The purpose this study was determine cardiovascular consequences chronic exposure. Female mice (C57BL/6 background strain) were randomly assigned daily vapor, standard (3R4F reference) cigarette smoke, or filtered air ( n = 15/group). Respective whole body exposures consisted four...
Background Small cell lung cancer (SCLC) is characterized by rapid progression and low survival rates. Therefore, novel therapeutic agents are urgently needed for this disease. Capsaicin, the active ingredient of chilli peppers, displays anti-proliferative activity in prostate epidermoid vitro. However, capsaicin has not been studied human SCLCs. The present manuscript fills void knowledge explores effect SCLC vitro vivo. Methodology/Principal Findings BrdU assays PCNA ELISAs showed that...
BackgroundNicotine induces the proliferation of non–small cell lung cancer (NSCLC) cells via nicotinic acetylcholine receptors and arrestin, β1 (ARRB1) protein. However, whether ARRB1 translocates to nucleus upon receptor activation how it regulates growth human NSCLCs are not known.
Despite its importance, the death rate of ovarian cancer has remained unchanged over past five decades, demanding an improvement in prevention and treatment this malignancy. With no known carcinogens, targeted is currently unavailable, efforts early detection malignancy by screening biomarkers have failed. The inhibition angiogenesis, also as angioprevention, a promising strategy to limit growth solid tumors, including cancers. Nobiletin, polymethoxy flavonoid compound isolated from...
The retinoblastoma tumor suppressor protein (Rb) plays a vital role in regulating mammalian cell cycle progression and inactivation of Rb is necessary for entry into S phase. inactivated by phosphorylation upon growth factor stimulation quiescent cells, facilitating the transition from G(1) phase to Although signaling events after have been well characterized, it not yet clear how these signals contact machinery. We had found previously that cells lead direct binding Raf-1 kinase Rb, leading...
Prohibitin is a growth regulatory gene that has pleiotropic functions in the nucleus, mitochondria, and cytoplasmic compartments. Earlier studies had proposed role for prohibitin modulating cellular senescence, but underlying mechanisms remain unknown. Here we show senescence induced by DNA-damaging agents causes localization of to specific heterochromatic foci. could bind heterochromatin protein 1 (HP1) family proteins colocalized with HP1γ senescence-associated Further, synergize repress...