A5101960786- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Peptidase Inhibition and Analysis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Pulmonary Hypertension Research and Treatments
- Animal Disease Management and Epidemiology
- Cervical Cancer and HPV Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
- Genetic and phenotypic traits in livestock
- Trace Elements in Health
- Brucella: diagnosis, epidemiology, treatment
- Ovarian function and disorders
- Cardiovascular Function and Risk Factors
Nanjing Medical University
2011-2025
Xinjiang Medical University
2025
Northwest Women's and Children's Hospital
2023-2024
State Key Laboratory of Natural Medicine
2019-2024
Zhongnan Hospital of Wuhan University
2023-2024
Yantaishan Hospital
2024
China Pharmaceutical University
2019-2024
National Clinical Research
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Tianjin Institute of Pharmaceutical Research (China)
2024
Abstract Intratumoral heterogeneity, including epithelial–mesenchymal transition (EMT), is one major cause of therapeutic resistance. The induction ferroptosis, an iron‐dependent death, has the potential in overcoming this resistance to traditional treatment modalities. However, roles distinct EMT phenotypes ferroptosis remain enigma. This study reports that 3D soft fibrin microenvironment confers colorectal cancer (CRC) cells hybrid phenotype and high level ferroptosis. activation histone...
Background Patient adherence is an important issue for health service providers and researchers. However, the knowledge structure of diverse research on treatment unclear. This study used co-word analysis social network techniques to analyze literature adherence, show their evolution over time. Methods Published scientific papers about were retrieved from Web Science (2000 May 2011). A total 2308 relevant articles included: 788 published in 2000–2005 1520 2006–2011. The keywords each article...
Small-sized titanium dioxide (TiO2) nanoparticles (< 10 nm) are widely used in both industry and daily life due to their enhanced thermomagnetic photocatalytic properties surface activity. However, increasing use increases the health risk of people exposed these particles, either occupationally or environmentally. This study was performed evaluate effect small-sized TiO2 on immune function rat pulmonary alveolar macrophages vivo. Forty-two rats were intra-tracheally instilled with 0.5, 5 50...
Brucellosis is a bacterial disease caused by brucella; mainly spread direct contact transmission through the brucella carriers, or indirect environment containing large quantities of bacteria discharged infected individuals. At beginning 21st century, epidemic among dairy cows in Zhejiang province, began to come back and has become localized prevalent epidemic. Combining pathology brucellosis, reported positive data characteristics, feeding method this paper establishes an dynamic model...
BackgroundThe current prevalence of tuberculosis (TB) in the People's Republic China (P. R. China) demonstrates geographical heterogeneities, which show that TB remote areas Western is more serious than coastal plain Eastern China. Although a lot ecological studies have been applied exploration on regional difference disease risks, there still paucity P. China.ObjectiveTo understand underlying factors contributing to inequity burden by using an approach and, thus, aiming provide basis...
Abstract Nitric oxide (NO) has a wide range of potential applications in tumor therapy. However, targeted delivery system for NO donors remained elusive, creating bottleneck that limits its druggability. The antibody–drug conjugate (ADC) is drug composed an antibody linked to active cytotoxic drug. This design may compensate the weak targeting ability and various biological functions donor. In this study, we designed donor HL-2, which had targeted, cleaved disulfide bond attachable maleimide...
Adeno-associated virus (AAV)-mediated gene therapy is widely applied to treat numerous hereditary diseases in animal models and humans. The specific expression of AAV-delivered transgenes driven by cell type-specific promoters should further increase the safety therapy. However, current methods for screening are labor-intensive time-consuming. Herein, we designed a "multiple vectors one AAV" strategy promoter construction vivo. Through this strategy, truncated native Myo15 hair cells (HCs)...
Cholinergic degeneration is one of the key pathological hallmarks Alzheimer’s disease (AD), a condition that characterized by synaptic disorders and memory impairments. Nerve growth factor (NGF) secreted in brain regions receive projections from basal forebrain cholinergic neurons. The trophic effects NGF rely on appropriate maturation its precursor, proNGF. ratio proNGF/NGF known to be increased patients with AD; however, mechanisms underlie this observation have yet elucidated. Here, we...
Abstract High altitude exposure increases the risk of myocardial ischemia (MI) and subsequent cardiovascular death. Machine learning techniques have been used to develop disease prediction models, but no reports exist for high induced ischemia. Our objective was establish a machine learning-based MI model identify key factors. Using prospective cohort study, predictive developed validated high-altitude MI. We consolidated health examination self-reported electronic questionnaire data...
Summary: Immunocytokines are a promising immunotherapeutic approach in cancer therapy. Anti–VEGFR2-interferon α (IFNα) suppressed colorectal (CRC) growth and enhanced CD8 + T-cell infiltration the tumor microenvironment, exhibiting great clinical translational potential. However, mechanism of how anti–VEGFR2-IFNα recruits T cells has not been elucidated. Here, we demonstrated that CRC metastasis infiltration. RNA sequencing revealed transcriptional activation CCL5 metastatic cells, which was...
Abstract Background Although the community health service system is now established in China, utilisation of institutions low due to lack a gate-keeping role primary providers and referrals among three-tiered institutions. In addition this, patients who can afford pay, often seek best services big hospitals guarantee quality care. Thus, need guiding increasing becoming an urgent problem, which hinders future development services. This study focuses on question how increase Chinese centres...
Dairy cattle brucellosis is a chronic bacterial disease, which caused by Brucella abortus and mainly characterized abortion in dairy cattle. With the rapid development of breeding industry milk cows China, infectious cases show an increasing trend. Particularly Jilin province, annual number positive was only 3 1987, went up to 168 2005. Based on situation infection we propose Susceptible-Exposed-Infected-Virus (SEIV) dynamical model with outside transferred amount describe transmission...
Cells and tissues, such as macrophages, express inducible nitric oxide synthase (INOS) after stimulation by certain factors. INOS helps mediate the macrophage inflammatory reaction, but few studies have explored how affects function in nonalcoholic fatty liver disease (NAFLD).