A5063753546- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Banana Cultivation and Research
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Plant tissue culture and regeneration
- Bone Tissue Engineering Materials
- Advancements in Transdermal Drug Delivery
- Protein Hydrolysis and Bioactive Peptides
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Horticultural and Viticultural Research
- Orthopaedic implants and arthroplasty
- Lipid Membrane Structure and Behavior
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Ocular Surface and Contact Lens
- Angiogenesis and VEGF in Cancer
- Advanced Drug Delivery Systems
- Osteoarthritis Treatment and Mechanisms
- Polysaccharides and Plant Cell Walls
- Dental Implant Techniques and Outcomes
- Chemical Synthesis and Analysis
- Amino Acid Enzymes and Metabolism
Shandong University
2016-2025
National Medical Products Administration
2023-2024
Regeneron (United States)
2024
Liaoning University of Traditional Chinese Medicine
2019-2023
Suzhou Municipal Hospital
2022
Nanjing Medical University
2022
State Council of the People's Republic of China
2020
Shangdong Agriculture and Engineering University
2017
Guangxi Academy of Agricultural Science
2011-2013
Czech Academy of Sciences, Institute of Biotechnology
2011
It is commonly observed that hydrophobic molecules alone cannot self-assemble into stable nanoparticles, requiring amphiphilic or ionic materials to support nanoparticle stability and function in vivo. We report herein newly self-assembled nanomedicines through entirely different mechanisms. present proof-of-concept methodology results of our hypothesis disulfide-induced (DSINMs) are promoted stabilized by the insertion a single disulfide bond molecules, order balance competition between...
The combination of paclitaxel (PTX) and doxorubicin (DOX) has been widely used in the clinic. However, it remains unsatisfied due to generation severe toxicity. Previously, we have successfully synthesized a prodrug PTX-S-DOX (PSD). displayed comparable vitro cytotoxicity compared with mixture free PTX DOX. Thus, speculated that could be promising improve anti-cancer effect reduce adverse effects by improving pharmacokinetics behavior PSD enhancing tumor accumulation. Due fact copper ions...
Recently, nanomedicine without drug carriers has attracted many pharmacists' attention. A novel paclitaxel–s–s–paclitaxel (PTX–s–s–PTX) conjugate with high loading (∼78%, w/w) was synthesized by conjugating paclitaxel to using disulfide linkage. The could self-assemble into uniform nanoparticles (NPs) 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR) encapsulated within the core of PTX–s–s–PTX NPs for photothermal therapy (PTT). DiR-loaded self-assembled (DSNs) had a mean...
Thymosin β-4(Tβ-4) is a macromolecular protein drug with potential for development in wound repair but limited by the shortcomings of protein, such as large volumes, poor membrane permeability, and unstable physicochemical characteristics. Ethosomes could enhance cell fluidity reduce epidermal density to make drugs through stratum corneum into deeper layers skin easily. Herein, we developed characterized novel transdermal delivery vehicle load peptides use Tβ-4 model wrapped ethosomes.We...
Despite standard treatment for non-small cell lung cancer (NSCLC) being surgical resection, recurrence and complications, such as induction of malignant pleural effusion (MPE) significant postoperative pain, usually result in failure. In this study, an alginate-based hybrid hydrogel (SOG) is developed that can be injected into the resection surface lungs during surgery. Briefly, endoplasmic reticulum-modified liposomes (MSLs) pre-loaded with signal transducer activator transcription 3...
The bioactivities and molecular mechanism of two novel antioxidant peptides were investigated by 3D-QSAR,<italic>in vitro</italic>evaluation MD simulations.