A5021310386- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Gastric Cancer Management and Outcomes
- Cardiac Arrest and Resuscitation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Trauma and Emergency Care Studies
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Cell death mechanisms and regulation
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Natural Compounds in Disease Treatment
- Sepsis Diagnosis and Treatment
- Lymphatic System and Diseases
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
Second Hospital of Shandong University
2015-2025
Shandong University
2011-2024
Jilin University
2023-2024
Tongji University
2022-2024
Shanghai Pulmonary Hospital
2022-2024
Novogene Bioinformatics Institute
2024
Wenzhou Medical University
2024
Dongyang People's Hospital
2024
Central Hospital of Zibo
2022
Shanxi Agricultural University
2022
Immunotherapy has been shown to be effective as a first-line treatment option for non-small cell lung cancer (NSCLC) patients. Unfortunately, it failed acquire an anticipant anti-tumour effect relatively lower clinical benefit rates. It is therefore important identify novel strategies improving immunotherapy. Endostar recombinant human endostatin that exerts its anti-angiogenic effects via vascular endothelial growth factor (VEGF)-related signalling pathways. Anti-programmed death receptor 1...
Investigating the genetic footprints of historical temperature selection can get insights to local adaptation and feasible influences climate change on long-term population dynamics.Chicken is a significative species study account its similar domestication track related human activity with most diversified varieties. Yet, few studies have demonstrated signatures naturally tropical frigid environments.Here, we generated whole genome resequencing 119 domesticated chickens in China including...
Background: Cancer cell-derived exosomal microRNAs (miRNAs) play critical role in orchestrating intercellular communication between tumor cells and microenvironmental factors, including lymphatic endothelial (LECs). Nevertheless, the functions underlying mechanisms of miRNAs metastasis lymphangiogenesis esophageal squamous cell carcinoma (ESCC) remain unclear. Methods: Small RNA sequencing, Gene Expression Omnibus (GEO) analysis qRT‒PCR were performed to identify candidate involved ESCC...
An increasing number of studies have suggested the dysbiosis salivary microbiome has been linked to advancement multiple diseases and proved be helpful for diagnosis them.Although epidemiological microbiota in carcinogenesis are mounting, no systemic study exists regarding oral non-small cell lung cancer (NSCLC) patients.In this study, we presented characteristics patients from NSCLC healthy controls by sequencing 16S rRNA microbial genes.Our result revealed distinct composition compared...
Abstract Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with esophageal squamous cell carcinoma (ESCC). Ubiquitin Specific Peptidase 21 (USP21) is dysregulated in plenty human cancers, however, its potential function and relevant molecular mechanisms ESCC malignant progression as well value translation remain largely unknown. Here, vitro vivo experiments revealed that aberrant upregulation USP21 accelerated proliferation...
Thymosin β-4(Tβ-4) is a macromolecular protein drug with potential for development in wound repair but limited by the shortcomings of protein, such as large volumes, poor membrane permeability, and unstable physicochemical characteristics. Ethosomes could enhance cell fluidity reduce epidermal density to make drugs through stratum corneum into deeper layers skin easily. Herein, we developed characterized novel transdermal delivery vehicle load peptides use Tβ-4 model wrapped ethosomes.We...
Abstract Esophageal squamous carcinoma (ESCC) is the major subtype of esophageal cancer in China, accounting for 90% cases. Recent studies revealed that abnormalities Hippo/YAP axis are pervasive ESCC and recognized as important driver progression. Since activity Hippo signaling controlled by phosphorylation cascade, it a mystery why effector YAP still over-activated when cascade inhibited. Several suggested addition to phosphorylation, other protein modifications such ubiquitination also...
Increasing evidence has shown that circular RNAs (circRNAs) interact with RNA-binding proteins (RBPs) and promote cancer progression. However, the function mechanism of circRNA/RBP complex in esophageal squamous cell carcinoma (ESCC) are still largely unknown. Herein, we first characterized a novel oncogenic circRNA, circ-FIRRE, by RNA sequencing (Ribo-free) profiling ESCC samples. Furthermore, observed marked circ-FIRRE overexpression patients high TNM stage poor overall survival....
In response to the high false positive rate of traditional Low-Dose Computed Tomography (LDCT) in diagnosing pulmonary malignant nodules, this study aimed investigate effectiveness scoring blood-based non-invasive biological metabolite detection combined with artificial intelligent imaging clinical diagnosis Pulmonary Nodules (PNs). retrospective study, risk was performed patients for nodules and subsequently, PNs were sampled by invasive procedures pathological examinations. The...
Background The study was conducted to investigate the effectiveness and cost of computed tomography (CT)‐guided percutaneous microwave ablation (MWA) thoracoscopic lobectomy for stage I non‐small cell lung cancer (NSCLC). Methods We retrospectively analyzed data 46 85 patients with NSCLC treated CT‐guided MWA or lobectomy, respectively, at our center from July 2013 June 2015. Overall survival (OS), disease‐free (DFS), local control rate, hospital stay, were evaluated. Survival curves...
Malignant pleural mesothelioma (MPM) is a rare form of cancer that associated with asbestos exposure. Unfortunately, current therapies have limited efficacy. Previous studies indicated curcumin exerts antiproliferative and antitumor effects, has low toxicity. The present study aimed to evaluate the anticancer effects on RN5 MPM cell line. inhibitory viability were determined using sulforhodamine B assay. In addition, cycle progression was analyzed by propidium iodide (PI) staining flow...
Chemotherapy is one of the primary treatments for both small cell lung cancer (SCLC) and non-small (NSCLC), however, chemoresistance develops over time a bottleneck to effective chemotherapy worldwide. Therefore, development new potent therapeutic agents overcome utmost importance. Triptolide natural component extracted from Tripterygium Wilfordii, Chinese plant; our study aimed evaluate its anti-tumor effects in taxol-resistant human adenocarcinoma investigate molecular mechanisms...
CD45, the leukocyte common antigen, is expressed on almost all cells of immunological and hematological systems. CD45 expression related to a variety diseases, including leukemia lymphoma. In this study, we analyzed level across cancers evaluated relationship between its patient prognosis. We further integrated methylation data explore differences in from multi-omics perspective. also levels immune cell infiltrates modifiers. Our results revealed distinct characteristics prognostic value...