A5051111217- Transplantation: Methods and Outcomes
- Occupational and environmental lung diseases
- Organ Transplantation Techniques and Outcomes
- Pulmonary Hypertension Research and Treatments
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Mechanical Circulatory Support Devices
- Venous Thromboembolism Diagnosis and Management
- Medical Imaging and Pathology Studies
- Renal Transplantation Outcomes and Treatments
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Radiation Dose and Imaging
- Tracheal and airway disorders
- Cardiac tumors and thrombi
- Polyomavirus and related diseases
- Myasthenia Gravis and Thymoma
- Organ and Tissue Transplantation Research
- Lung Cancer Research Studies
- Cardiovascular Function and Risk Factors
- Vascular Anomalies and Treatments
- Cardiovascular Issues in Pregnancy
- RNA Interference and Gene Delivery
Toronto General Hospital
2016-2025
Princess Margaret Cancer Centre
2016-2025
University of Toronto
2016-2025
University Health Network
2016-2025
Health Net
2004-2024
St Joseph's Health Centre
2024
NeoGenomics (United States)
2024
Toronto East General Hospital
2024
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
More than 80% of donor lungs are potentially injured and therefore not considered suitable for transplantation. With the use normothermic ex vivo lung perfusion (EVLP), retrieved can be perfused in an circuit, providing opportunity to reassess its function before In this study, we examined feasibility transplanting high-risk that have undergone EVLP.In prospective, nonrandomized clinical trial, subjected high risk transplantation 4 hours EVLP. High-risk were defined by specific criteria,...
Background— Chronic thromboembolic pulmonary hypertension (CTEPH) is often a sequel of venous thromboembolism with fatal natural history; however, many cases can be cured by endarterectomy. The clinical characteristics and current management patients enrolled in an international CTEPH registry was investigated. Methods Results— included 679 newly diagnosed (≤6 months) consecutive CTEPH, from February 2007 until January 2009. Diagnosis confirmed right heart catheterization,...
Background— Chronic thromboembolic pulmonary hypertension, a rare complication of acute embolism, is characterized by fibrothrombotic obstructions large arteries combined with small-vessel arteriopathy. It can be cured endarterectomy, and clinically improved medical therapy in inoperable patients. A European registry was set up 27 centers to evaluate long-term outcome correlates 2 distinct populations operated not-operated patients who have chronic hypertension. Methods Results— total 679...
In Brief Acute lung injury (ALI) may complicate thoracic surgery and is a major contributor to postoperative mortality. We analyzed risk factors for ALI in cohort of 879 consecutive patients who underwent pulmonary resections non-small cell carcinoma. Clinical, anesthetic, surgical, radiological, biochemical, histopathologic data were prospectively collected. The total incidence was 4.2% (n = 37). 10 cases, intercurrent complications (bronchopneumonia, n 5; bronchopulmonary fistula, 2;...
Treatment of damaged donor lungs with the cytokine interleukin-10 improves their function, allowing previously unacceptable organs to be used for transplantation.
Malignant pleural mesothelioma (MPM) remains associated with poor outcome. We examined the results of trimodality therapy cisplatin-based chemotherapy followed by extrapleural pneumonectomy (EPP) and adjuvant high-dose (50 to 60 Gy) hemithoracic radiation for MPM.We conducted a retrospective review all patients prospectively evaluated protocol between January 2001 December 2007 in our institution.A total were suitable candidates. Histology was epithelioid (n = 44) or biphasic 16)....
Chronic postsurgical pain (CPSP), an often unanticipated result of necessary and even life-saving procedures, develops in 5-10% patients one-year after major surgery. Substantial advances have been made identifying at elevated risk developing CPSP based on perioperative pain, opioid use, negative affect, including depression, anxiety, catastrophizing, posttraumatic stress disorder-like symptoms. The Transitional Pain Service (TPS) Toronto General Hospital (TGH) is the first to...
New biomarkers are needed to detect pleural mesothelioma at an earlier stage and individualize treatment strategies. We investigated whether fibulin-3 in plasma effusions could meet sensitivity specificity criteria for a robust biomarker.
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown cause characterised by progressive fibrotic formation in lung tissue. We hypothesise that disrupted metabolic pathways IPF contribute to pathogenesis.Metabolomics human was performed using mass spectroscopy (IPF lung=8; donor lung=8). Gene expression key enzymes measured microarrays. Of the 108 metabolites whose levels were found altered, 48 significantly increased, whereas 60 decreased samples compared with normal...
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following guideline development process as outlined in Methodology Manual . follow Conflict Interest Policy Clinical Practice other guidance (“Guidance”) provided by is not a or definitive guide to treatment options. It intended voluntary use clinicians should be used conjunction independent professional judgment. Guidance may applicable all patients,...
Cytokines have been shown to play an important role in promoting inflammation the setting of ischemia-reperfusion injury. However, their human lung transplantation has not systematically explored. This study was undertaken examine kinetics cytokine release 18 consecutive procedures and relationships between levels donor factors, length ischemic time, allograft function. TNF-alpha, IFN-gamma, IL-10, IL-12, IL-18 were found at higher during whereas IL-8 predominantly increased after...