A5033531825- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Function and Risk Factors
- Asthma and respiratory diseases
- Vascular Anomalies and Treatments
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Cardiovascular Issues in Pregnancy
- Lung Cancer Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Pneumonia and Respiratory Infections
- Blood Coagulation and Thrombosis Mechanisms
- Pleural and Pulmonary Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Sarcoidosis and Beryllium Toxicity Research
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Medical Imaging and Pathology Studies
OLVG
2016-2025
Isabela State University
2023
Medisch Centrum Haaglanden
2020
Spaarne Gasthuis
2020
Amsterdam UMC Location University of Amsterdam
2007-2018
University of Pretoria
2017-2018
University of Amsterdam
2007-2016
KU Leuven
2003-2016
Medical University of Vienna
2011-2016
St. Antonius Ziekenhuis
2016
Background— Chronic thromboembolic pulmonary hypertension (CTEPH) is often a sequel of venous thromboembolism with fatal natural history; however, many cases can be cured by endarterectomy. The clinical characteristics and current management patients enrolled in an international CTEPH registry was investigated. Methods Results— included 679 newly diagnosed (≤6 months) consecutive CTEPH, from February 2007 until January 2009. Diagnosis confirmed right heart catheterization,...
Background— Chronic thromboembolic pulmonary hypertension, a rare complication of acute embolism, is characterized by fibrothrombotic obstructions large arteries combined with small-vessel arteriopathy. It can be cured endarterectomy, and clinically improved medical therapy in inoperable patients. A European registry was set up 27 centers to evaluate long-term outcome correlates 2 distinct populations operated not-operated patients who have chronic hypertension. Methods Results— total 679...
Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype-Phenotype Relationship in Sarcoidosis) project represents European multicentre study to investigate the influence genotype on phenotypes sarcoidosis.The baseline phenotype module comprised 2163 Caucasian patients with sarcoidosis who were phenotyped at 31 centres according standardised protocol.From this module, we found that acute onset mainly female, young and Scadding...
To compare the effectiveness of discontinuing treatment with amoxicillin after three days or eight in adults admitted to hospital mild moderate-severe community acquired pneumonia who substantially improved an initial days' treatment.Randomised, double blind, placebo controlled non-inferiority trial.Nine secondary and tertiary care hospitals Netherlands.Adults (pneumonia severity index score < = 110).Patients had intravenous were randomly assigned oral (n 63) 56) times daily for five...
Background Mechanical ventilation with high tidal volumes aggravates lung injury in patients acute or respiratory distress syndrome. The authors sought to determine the effects of short-term mechanical on local inflammatory responses without preexisting injury. Methods Patients scheduled undergo an elective surgical procedure (lasting &gt; = 5 h) were randomly assigned either higher 12 ml/kg ideal body weight and no positive end-expiratory pressure (PEEP) lower 6 10 cm H2O PEEP. After...
Alveolar fibrin deposition is a hallmark of acute lung injury, resulting from activation coagulation and inhibition fibrinolysis. Previous studies have shown that mechanical ventilation with high tidal volumes may aggravate injury in patients sepsis injury. The authors sought to determine the effects on alveolar hemostatic balance without preexistent injury.Patients scheduled for an elective surgical procedure (lasting > or = 5 h) were randomly assigned either higher 12 ml/kg ideal body...
The innate immune response is important in ventilator-induced lung injury (VILI) but the exact pathways involved are not elucidated. authors studied role of intracellular danger sensor NLRP3 inflammasome.NLRP3 inflammasome gene expression was analyzed respiratory epithelial cells and alveolar macrophages obtained from ventilated patients (n = 40). In addition, wild-type deficient mice were randomized to low tidal volume (approximately 7.5 ml/kg) high 15 ventilation. presence uric acid...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a deadly disease with increasingly impaired health-related quality of life (HRQOL). eHealth technologies facilitate collection physiological outcomes and patient-reported at home, but randomized controlled trials (RCTs) on the effects are scarce.Objectives: To investigate whether home monitoring program improves HRQOL medication use for patients IPF.Methods: We performed multicenter RCT in newly treated IPF. Patients were randomly assigned to...
Nonencapsulated Haemophilus influenzae often causes chronic infections of the lower respiratory tract in both nonobstructive and obstructive bronchitis. We assessed airway inflammation clinically stable, chronically H. influenzae-infected patients with (CB–HI, n = 10) bronchitis (COPD–HI, by analyses sol phase spontaneously expectorated sputum (SSP). As compared CB–HI group, COPD–HI group had significantly higher (p < 0.05) levels myeloperoxidase (MPO) tumor necrosis factor (TNF)- α their...
Pathophysiological findings in chronic thromboembolic pulmonary hypertension (CTEPH) have suggested that a secondary small vessel arteriopathy may contribute to the haemodynamic impairment observed these patients. It was hypothesised this element of elevated vascular resistance be responsive continuous intravenous epoprostenol therapy. Retrospectively, clinical and responses were evaluated nine CTEPH patients who subsequently underwent thromboendarterectomy (PTE). Cardiopulmonary...
Salmeterol is a beta2-adrenoreceptor agonist used in the treatment of obstructive pulmonary disease. inhibits inflammatory responses by neutrophils and mononuclear cells vitro mouse models lung inflammation vivo.To determine effect salmeterol on LPS-induced humans.Thirty-two healthy subjects were enrolled single-blinded, placebo-controlled study. Subjects inhaled 100 microg or placebo (t=-0.5 h) followed LPS normal saline (t=0 h; n=8/group). Measurements performed bronchoalveolar lavage...
Interventricular mechanical dyssynchrony is a characteristic of pulmonary hypertension. We studied the role right ventricular (RV) wall stress in recovery interventricular dyssynchrony, after endarterectomy (PEA) chronic thromboembolic hypertension (CTEPH). In 13 consecutive patients with CTEPH, before and 6 months endarterectomy, cardiovascular magnetic resonance myocardial tagging was applied. For left (LV) RV free walls, time to peak (Tpeak) circumferential shortening (strain) calculated....
Vitamin D deficiency is frequently found in patients with chronic obstructive pulmonary disease (COPD). has antimicrobial, anti-inflammatory, and immunomodulatory effects. Therefore, supplementation may prevent COPD exacerbations, particularly deficient patients.We aimed to assess the effect of vitamin on exacerbation rate D-deficient COPD.We performed a multicenter, double-blind, randomized controlled trial. ≥1 exacerbations preceding year (15-50 nmol/L) were randomly allocated 1:1 ratio...
Background In non-thromboembolic pulmonary hypertension, endothelin (ET)-1 levels are increased and correlate with the hemodynamic severity of disease. Whether such correlations exist in chronic thromboembolic hypertension (CTEPH) is unknown, nor whether ET-1 outcome after endarterectomy (PEA). Methods Results were determined by ELISA. ET-levels 35 CTEPH patients (1.62±0.21 pg/ml) compared healthy controls (n=11: 0.75±0.06 pg/ml, p<0.02). correlated (all p<0.0001) mean artery pressure (mPAP)...
Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is considered to be important for an appropriate immune response against pathogens that enter the lower airways.We studied effects two different TLR agonists relevant respiratory infections in human lung: lipoteichoic acid (LTA; TLR2 agonist, component gram-positive bacteria) and lipopolysaccharide (LPS; TLR4-agonist, gram-negative bacteria).Fifteen healthy subjects were given LPS or LTA: bronchoscope,...