A5068855118- Preterm Birth and Chorioamnionitis
- Maternal and Perinatal Health Interventions
- Gynecological conditions and treatments
- Neonatal Respiratory Health Research
- Pregnancy-related medical research
- Uterine Myomas and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Infant Development and Preterm Care
- Maternal and fetal healthcare
- Endometrial and Cervical Cancer Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and preeclampsia studies
- Posttraumatic Stress Disorder Research
- Ectopic Pregnancy Diagnosis and Management
- Pelvic floor disorders treatments
- Child Abuse and Trauma
- Patient Satisfaction in Healthcare
- Gestational Diabetes Research and Management
- Emergency and Acute Care Studies
- Ovarian function and disorders
- Antibiotic Use and Resistance
- Psoriasis: Treatment and Pathogenesis
- Neonatal and fetal brain pathology
- Pneumonia and Respiratory Infections
University Hospitals Bristol and Weston NHS Foundation Trust
2022-2024
University Hospitals Bristol NHS Foundation Trust
2017-2024
National Institute for Health Research
2017-2022
University of Amsterdam
2012-2021
Amsterdam University Medical Centers
2012-2021
NIHR Applied Research Collaboration West
2020
Academic Medical Center
2010-2019
Spaarne Gasthuis
2019
University Medical Center Utrecht
2008-2018
Máxima Medisch Centrum
2009-2018
Methotrexate and cyclosporine are well-known systemic therapies for moderate-to-severe chronic plaque psoriasis. We conduced a randomized, controlled trial comparing methotrexate in terms of effectiveness, side effects, the quality life.
In patients with severe secondary peritonitis, there are 2 surgical treatment strategies following an initial emergency laparotomy: planned relaparotomy and only when the patient's condition demands it ("on-demand"). The on-demand strategy may reduce mortality, morbidity, health care utilization, costs. However, randomized trials have not been performed.To compare patient outcome, costs of relaparotomy.Randomized, nonblinded clinical trial at academic 5 regional teaching hospitals in...
To compare the effectiveness of discontinuing treatment with amoxicillin after three days or eight in adults admitted to hospital mild moderate-severe community acquired pneumonia who substantially improved an initial days' treatment.Randomised, double blind, placebo controlled non-inferiority trial.Nine secondary and tertiary care hospitals Netherlands.Adults (pneumonia severity index score < = 110).Patients had intravenous were randomly assigned oral (n 63) 56) times daily for five...
Background At present, there is insufficient evidence to guide appropriate management of women with preterm prelabor rupture membranes (PPROM) near term. Methods and Findings We conducted an open-label randomized controlled trial in 60 hospitals The Netherlands, which included non-laboring >24 h PPROM between 34+0 37+0 wk gestation. Participants were randomly allocated a 1∶1 ratio induction labor (IoL) or expectant (EM) using block randomization. main outcome was neonatal sepsis. Secondary...
Purpose To investigate whether initial diagnostic laparoscopy can prevent futile primary cytoreductive surgery (PCS) by identifying patients with advanced-stage ovarian cancer in whom > 1 cm of residual disease will be left after PCS. Patients and Methods This multicenter, randomized controlled trial was undertaken within eight gynecologic centers the Netherlands. suspected who qualified for PCS were eligible. Participating randomly assigned to either or Laparoscopy used guide selection...
To estimate the performance of combining cervical length measurement with fetal fibronectin testing in predicting delivery women symptoms preterm labor.We conducted a prospective nationwide cohort study all 10 perinatal centers The Netherlands. Women labor between 24 and 34 weeks gestation intact membranes were included. In women, qualitative (0.050-microgram/mL cutoff) performed. Logistic regression was used to predict spontaneous within 7 days after testing. A risk less than 5%,...
Objective To develop a clinical prediction rule that can help the clinician to identify women at high and low risk for gestational diabetes mellitus (GDM) early in pregnancy order improve efficiency of GDM screening. Design We used data from prospective cohort study rule. Setting The original was conducted university hospital Netherlands. Population Nine hundred ninety‐five consecutive pregnant underwent screening GDM. Methods Using multiple logistic regression analysis, we constructed model...