A5021966221- Congenital Heart Disease Studies
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Issues in Pregnancy
- Preterm Birth and Chorioamnionitis
- Congenital heart defects research
- Neonatal Respiratory Health Research
- Pregnancy-related medical research
- Neonatal and fetal brain pathology
- Congenital Anomalies and Fetal Surgery
- Birth, Development, and Health
- Ectopic Pregnancy Diagnosis and Management
- Tracheal and airway disorders
- Maternal and Perinatal Health Interventions
- Ultrasound in Clinical Applications
- Domain Adaptation and Few-Shot Learning
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Renal and related cancers
- Cardiac Arrhythmias and Treatments
- Maternal and fetal healthcare
- Tumors and Oncological Cases
Leiden University Medical Center
2016-2025
Leiden University
2014-2025
Amsterdam University Medical Centers
2023
Hudson Institute
2018-2021
John Wiley & Sons (United Kingdom)
2018-2021
Texas Children's Hospital
2019
Baylor College of Medicine
2019
University Medical Center Utrecht
2015-2018
Máxima Medisch Centrum
2018
University Medical Center
2018
The Netherlands launched a nationwide implementation study on non-invasive prenatal testing (NIPT) as first-tier test offered to all pregnant women. This started April 1, 2017 the TRIDENT-2 study, licensed by Dutch Ministry of Health. In first year, NIPT was performed in 73,239 pregnancies (42% pregnancies), 7,239 (4%) chose first-trimester combined testing, and 54% did not participate. number trisomies 21 (239, 0.33%), 18 (49, 0.07%), 13 (55, 0.08%) found this is comparable earlier studies,...
Objective Congenital heart disease ( CHD ) is the most common congenital malformation and causes major morbidity mortality. Prenatal detection improves neonatal condition before surgery, resulting in less In Netherlands a national prenatal screening programme was introduced 2007. This study evaluates effects of this programme. Design Geographical cohort study. Setting Large referral region three tertiary care centres. Population Fetuses infants diagnosed with severe born between 1 January...
Background At present, there is insufficient evidence to guide appropriate management of women with preterm prelabor rupture membranes (PPROM) near term. Methods and Findings We conducted an open-label randomized controlled trial in 60 hospitals The Netherlands, which included non-laboring >24 h PPROM between 34+0 37+0 wk gestation. Participants were randomly allocated a 1∶1 ratio induction labor (IoL) or expectant (EM) using block randomization. main outcome was neonatal sepsis. Secondary...
ABSTRACT Objective Congenital heart defects (CHD) are still missed frequently in prenatal screening programs, which can result severe morbidity or even death. The aim of this study was to evaluate the quality fetal images, obtained during second‐trimester standard anomaly scan (SAS) cases CHD, explore factors associated with a diagnosis. Methods In case–control study, all fetus born isolated CHD Northwestern region Netherlands, between 2015 and 2016, were extracted from PRECOR registry....
To estimate the performance of combining cervical length measurement with fetal fibronectin testing in predicting delivery women symptoms preterm labor.We conducted a prospective nationwide cohort study all 10 perinatal centers The Netherlands. Women labor between 24 and 34 weeks gestation intact membranes were included. In women, qualitative (0.050-microgram/mL cutoff) performed. Logistic regression was used to predict spontaneous within 7 days after testing. A risk less than 5%,...
<h3>Background</h3> Delayed umbilical cord clamping (DCC) affects the cardiopulmonary transition and blood volume in neonates immediately after birth. However, little is known of flow vessels birth during DCC. The objective to describe duration patterns through <h3>Methods</h3> Arterial venous was measured DCC using Doppler ultrasound uncomplicated term vaginal deliveries. Immediately birth, probe placed middle cord, pattern vein arteries were evaluated until clamping. <h3>Results</h3>...
Monochorionic twins share a single placenta and are connected with each other through vascular anastomoses. Unbalanced inter-twin blood transfusion may lead to various complications, including twin-to-twin syndrome (TTTS) twin anemia polycythemia sequence (TAPS). TAPS was first described less than decade ago, the pathogenesis of results from slow donor recipient few minuscule This gradually leads in recipient, absence oligo-polyhydramnios (TOPS). occur spontaneously 3-5% monochorionic or...
To investigate the diagnostic accuracy of delta middle cerebral artery peak systolic velocity (MCA-PSV) > 0.5 multiples median (MoM) and compare its predictive value with that current MCA-PSV cut-off values 1.5 MoM in donor < 1.0 recipient, for diagnosis twin anemia-polycythemia sequence (TAPS) monochorionic pregnancy.This was a retrospective consecutive cohort study comprising all uncomplicated pregnancies postnatal TAPS managed between 2003 2017 Dutch national referral center fetal...
Abstract Objective To evaluate which cytogenetic characteristics of confined placental mosaicism (CPM) detected in the first trimester chorionic villi and/or placentas terms chromosome aberration, cell lineage involved and trisomy origin will lead to fetal growth restriction low birthweight. Methods Cohort study using routinely collected perinatal data non‐invasive prenatal testing, sampling postnatal placentas. Results 215 CPM cases were found. Fetal (FGR) birthweight below 10 th percentile...
The aim of this study was to explore aspects the meaning home as experienced by very old single-living people in Sweden. A grounded theory approach used, and interviews were conducted with 40 men women aged 80–89. findings indicate that has a central place lives because it is where they live spend so much time. significance based on fact means many different things participants. theme comprises two key categories: security freedom. Each these three sub-categories. In security, are: living...
To evaluate the prenatal detection of transposition great arteries (TGA), after introduction a Dutch screening program in 2007, as well effect on pre- and postsurgical mortality morbidity.In geographical cohort study, all infants with TGA who were born between 1 January 2002 2012 included. The cases divided into two groups: those without diagnosis. Pre- was assessed, follow-up year. Presurgical morbidity assessed terms cardiovascular compromise, metabolic acidosis, renal and/or hepatic...
Congenital heart defects (CHD) are associated with genetic syndromes. Rapid aneuploidy testing and chromosome microarray analysis (CMA) standard care in fetal CHD. Many syndromes remain undetected these tests. This cohort study aims to estimate the frequency of causal variants, particular structural abnormalities sequence fetuses severe CHD at mid-gestation, aid prenatal counselling.Fetuses were extracted from PRECOR registry (2012-2016). We evaluated pre- postnatal results retrospectively...
Abstract Objectives To give an overview of the genetic and structural abnormalities occurring in fetuses with nuchal translucency (NT) measurement exceeding 95th percentile at first‐trimester screening to investigate which these would be missed if cell‐free fetal DNA (cfDNA) were used as a first‐tier test for chromosomal abnormalities. Methods This is national study including 1901 pregnancies NT≥95th referred seven university hospitals Netherlands between 1 January 2010 2016. All cases...
Objective To examine the accuracy of fetal echocardiography in diagnosing congenital heart disease (CHD) at medicine units three tertiary care centers. Methods This was a multicenter cohort study referrals between 2002 and 2012. Prenatal postnatal diagnoses were compared degree agreement classified as 'correct' (anatomy correct diagnosis led to similar outcome expected), 'discrepant' (anatomical discrepancies present but severity prognosis defect diagnosed correctly) or 'no similarity' (the...
Background Neonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal injury and adverse long‐term neurodevelopmental outcomes. Given the vital role of placenta fetal growth, we assessed incidence placental pathology explored its association total regional volumes, gyrification, after birth. Methods Results Placentas from 96 term singleton pregnancies severe were prospectively analyzed macroscopic microscopic pathology. We...
Transvaginal echocardiography is still rarely incorporated into the first-trimester ultrasound examination, despite fact that heart defects are most frequently encountered congenital malformation. This study was undertaken to explore possibilities of fetal in late first trimester.In 85 women with uncomplicated singleton pregnancies, three transvaginal examinations between 11+0 and 13+6 weeks' gestation were performed. The carried out at weekly intervals visualization several...
We investigated the predictive capacity of mid-trimester cervical length (CL) measurement for spontaneous and iatrogenic preterm birth.We performed a prospective observational cohort study in nulliparous women low-risk multiparous with singleton pregnancy between 16(+0) 21(+6) weeks gestation. assessed prognostic transvaginally measured CL birth (<37 weeks) using likelihood ratios (LR) receiver-operating-characteristic analysis. calculated numbers needed to screen prevent one assuming...
ABSTRACT Objectives To evaluate the long‐term neurodevelopmental and behavioral outcomes in surviving infants of pregnancies with spontaneous twin anemia–polycythemia sequence (TAPS), to compare outcome between donors recipients, investigate potential risk factors for impairment (NDI). Methods This was a retrospective study consecutive cohort spontaneous‐TAPS survivors delivered 2005 2017 at Leiden University Medical Center, The Netherlands. Neurological, motor, cognitive development were...