A5054411650- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Prenatal Screening and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parvovirus B19 Infection Studies
- Lipid metabolism and disorders
- Bariatric Surgery and Outcomes
- Non-Invasive Vital Sign Monitoring
- Sleep and related disorders
- Cardiovascular and Diving-Related Complications
- Pregnancy and preeclampsia studies
- Family and Patient Care in Intensive Care Units
- Tumors and Oncological Cases
- Congenital Anomalies and Fetal Surgery
- Sleep and Work-Related Fatigue
- Peroxisome Proliferator-Activated Receptors
- Pediatric Pain Management Techniques
- Restless Legs Syndrome Research
- Diet and metabolism studies
- Abdominal Trauma and Injuries
- Cardiovascular Syncope and Autonomic Disorders
Eindhoven University of Technology
2024
Kempenhaeghe
2024
Stanford University
2023-2024
Stanford Medicine
2024
Palo Alto University
2024
OLVG
2021-2022
Academic Center for Dentistry Amsterdam
2022
University of Groningen
2017-2019
University Medical Center Groningen
2017-2019
Abstract Objectives To give an overview of the genetic and structural abnormalities occurring in fetuses with nuchal translucency (NT) measurement exceeding 95th percentile at first‐trimester screening to investigate which these would be missed if cell‐free fetal DNA (cfDNA) were used as a first‐tier test for chromosomal abnormalities. Methods This is national study including 1901 pregnancies NT≥95th referred seven university hospitals Netherlands between 1 January 2010 2016. All cases...
Determining interventions to manage obstructive sleep apnea (OSA) depends on clinical examination, polysomnography (PSG) results, and imaging analysis. There remains the need of a noninvasive cost-effective way correlate relevant upper airway anatomy with severity OSA direct treatment optimize outcome.
(1) To investigate if drug-induced sleep endoscopy (DISE) findings are predictive of surgical response for patients undergoing maxillomandibular advancement (MMA) obstructive apnea (OSA) and (2) to the value jaw thrust maneuver during DISE in terms MMA.
Data on adherence and outcome of upper airway stimulation (UAS) for patients with obstructive sleep apnea (OSA) are collected in an international registry (ADHERE). Previous publications report significant improvement self-reported objective OSA outcomes, durable effectiveness, high adherence. Debate remains whether the effectiveness UAS is influenced by preoperative severity; therefore, we aimed to evaluate this using data from ADHERE Registry.ADHERE a postmarket, ongoing, multicenter...
Numerous types of mandibular advancement devices (MADs) are available to treat patients with obstructive sleep apnea, varying from noncustom custom devices. Only a limited number studies have been performed determine whether MAD could be used predict treatment success MAD. In this study, we investigated the potential new-generation MAD, by comparing its effectiveness We hypothesized that is similar regard both objective (polysomnography) and self-reported (questionnaires, adherence, patient...
Mandibular Advancement Devices (MAD's) are oral appliances commonly used in treatment of Obstructive Sleep Apnea (OSA). OSA severity and certain other factors, such as BMI neck circumference, correlate with MAD therapy success. So far, the predictive value dental parameters, profile, molar-classification, overjet, overbite, maximal retrusion, protrusion protrusive range, has not been fully investigated.
The primary aim was to predict upper airway collapse sites found in drug-induced sleep endoscopy (DISE) from demographic, anthropometric, clinical examination, study, and snoring sound parameters patients with obstructive apnea (OSA). secondary identify the above-mentioned that are associated complete concentric of soft palate.
Background Weight-loss surgery is one of the recommended methods for treating obstructive sleep apnea (OSA) in obese patients. While weight reduction critical to relieve symptoms OSA, biochemical factors involved post-surgery improvement are still unknown. We aimed explore link between ANGPTL7 and OSA patients with different severity. Furthermore, we examined effect bariatric on level. Methods quantified levels circulating fasting plasma adipose tissue samples 88 participants before after...
Overnight sleep staging is an important part of the diagnosis various disorders. Polysomnography gold standard for staging, but less-obtrusive sensing modalities are emerging interest. Here, we developed and validated algorithm to perform “proxy” using cardiac respiratory signals derived from a chest-worn accelerometer. We collected data in two centers, accelerometer combination with full PSG. A total 323 participants were analyzed, aged 13–83 years, BMI 18–47 kg/m2. features then applied...
Surgery induced stress and anxiety in children parents can be reduced by providing preoperative information adapted to their needs. Aim of this study was evaluate the effects three different modalities (coloring page, mobile application videos) prepare for day-care surgery on postoperative pain experienced child, satisfaction parents.Prospective observational including that were offered specifically developed surgery. Results compared between used none (i.e., control group) versus one or...
Identification of phenotypes and endotypes contributes to a better understanding the complex pathophysiology heterogeneous clinical presentation obstructive sleep apnea. The general goal this dissertation was determine added value identification use potential predictors; risk factors associated with apnea influencing treatment outcome. By identifying predictors, specificity sensitivity diagnostic tools can be increased. In addition, these predictors provide guidance in choosing from options,...
Abstract Introduction Upper Airway Stimulation is an approved technology for the treatment of moderate to severe obstructive sleep apnea. Differences exist among specific indications use and/or coverage limits, with certain geographies supporting a broader AHI range (15-65 events/hr) compared others that are limited narrower (AHI 20-50 events/hr). This study provides comparison outcomes related these two groups. Methods retrospective analysis data sets: (1) STAR pivotal set, including only...
To describe fetal abnormalities associated with a nuchal translucency (NT)>95th percentile measured at first trimester screening and investigate which of these anomalies would be missed if cell free DNA (cfDNA) replaced an early scan. This is retrospective study including 1661 pregnancies from five academic hospitals in the Netherlands NT≥p95 between 01-01-2010 31-12-2015. All cases unknown pregnancy outcome were excluded. Pre- postnatal information, results karyotyping, detailed ultrasound...