A5039654436- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Parvovirus B19 Infection Studies
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Pediatric Urology and Nephrology Studies
- Congenital Diaphragmatic Hernia Studies
- Gestational Diabetes Research and Management
- Renal and related cancers
- Congenital Anomalies and Fetal Surgery
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Cardiovascular Issues in Pregnancy
- Urological Disorders and Treatments
- Pregnancy-related medical research
- Congenital heart defects research
- Ethics and Legal Issues in Pediatric Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
University Medical Center Utrecht
2016-2025
Utrecht University
2016-2025
Wilhelmina Children's Hospital
2016-2025
University Medical Center
2019-2024
National Institute for Public Health and the Environment
2023
Vrije Universiteit Amsterdam
2001-2023
Erasmus MC
2019-2023
Erasmus University Rotterdam
2023
Amsterdam University Medical Centers
2023
University Hospital Heidelberg
2016-2020
The Netherlands launched a nationwide implementation study on non-invasive prenatal testing (NIPT) as first-tier test offered to all pregnant women. This started April 1, 2017 the TRIDENT-2 study, licensed by Dutch Ministry of Health. In first year, NIPT was performed in 73,239 pregnancies (42% pregnancies), 7,239 (4%) chose first-trimester combined testing, and 54% did not participate. number trisomies 21 (239, 0.33%), 18 (49, 0.07%), 13 (55, 0.08%) found this is comparable earlier studies,...
Objective To evaluate the clinical impact of nationwide implementation genome-wide non-invasive prenatal testing (NIPT) in pregnancies at increased risk for fetal trisomies 21, 18 and 13 (TRIDENT study). Method Women with elevated based on first trimester combined (FCT ≥ 1:200) or medical history, not advanced maternal age alone, were offered NIPT as contingent screening test, performed by Dutch University Medical laboratories. We analyzed uptake, test performance, redraw/failure rate,...
In the TRIDENT-2 study, all pregnant women in Netherlands are offered genome-wide non-invasive prenatal testing (GW-NIPT) with a choice of receiving either full screening or solely for common trisomies. Previous data showed that GW-NIPT can reliably detect trisomies general obstetric population and this test also other chromosomal abnormalities (additional findings). However, evidence regarding clinical impact additional findings is lacking. Therefore, we present follow-up results study to...
Women with complicated pregnancies often require hospital admission. Telemonitoring at home is a promising alternative that fulfils worldwide need in obstetric health care. Moreover, the COVID-19 pandemic has accelerated transformation to digital The aim of this study was evaluate safety, clinical effectiveness, patient satisfaction, and costs telemonitoring against care pregnancies.
Abstract Objectives To give an overview of the genetic and structural abnormalities occurring in fetuses with nuchal translucency (NT) measurement exceeding 95th percentile at first‐trimester screening to investigate which these would be missed if cell‐free fetal DNA (cfDNA) were used as a first‐tier test for chromosomal abnormalities. Methods This is national study including 1901 pregnancies NT≥95th referred seven university hospitals Netherlands between 1 January 2010 2016. All cases...
ABSTRACT Objective Fetal megacystis presents a challenge in terms of counseling and management because its varied etiology evolution. The aim this study was to present comprehensive overview the underlying etiologies structural anomalies associated with fetal megacystis. Methods This retrospective multicenter cases referred medicine unit one eight academic hospitals Netherlands diagnosis For each case, data on measurements urinary tract were collected. All available postmortem examinations...
To evaluate the application of non-invasive prenatal testing (NIPT) as an alternative to invasive diagnostic in pregnancies with abnormal ultrasound findings.This was a retrospective analysis 251 singleton and multiple at high risk for fetal chromosomal abnormality based on findings sonographic examination, which NIPT performed first-tier genetic test. by massively parallel sequencing cell-free DNA maternal plasma, allowing genome-wide detection whole-chromosome, well partial, autosomal...
Hospital admission during pregnancy complications is considered to be an event of significant impact. Besides conventional in-clinic maternal and fetal monitoring, recent technologies enable home-based telemonitoring with self-measurements in high risk pregnancy. This study part a feasibility pilot explore the usability acceptability aims gain insight experiences preferences pregnant women concerning novel strategy telemonitoring, opposed who were hospitalized pregnancy.Using secured...
In women at risk of developing preeclampsia, we evaluated the use a digital health platform for telemonitoring blood pressure and symptoms combined with minimal antenatal visit schedule. A case-control study chronic hypertension, history or maternal cardiac kidney disease. care path was designed reduced visits enhanced ([email protected]) daily symptom monitoring starting from 16 weeks gestation. Home-measurements were monitored in-hospital by obstetric professionals, taking actions upon...
Preterm birth is the leading cause of neonatal morbidity and mortality. The recurrence rate spontaneous preterm high, additional preventive measures are required. Our objective was to assess effectiveness low-dose aspirin compared placebo in prevention women with a previous birth.
Noninvasive prenatal testing by cell-free DNA analysis is offered to pregnant women worldwide screen for fetal aneuploidies. In noninvasive testing, the fraction of in maternal circulation measured as a quality control parameter. Given that originates from placenta, might also reflect placental health and pregnancy adaptation.
This study evaluates pregnant women's and healthcare professionals' preferences regarding specific prenatal screening diagnostic test characteristics.A discrete choice experiment was developed to assess for tests that differed in seven attributes: minimal gestational age, time results, level of information, detection rate, false positive miscarriage risk costs.The questionnaire completed by 596 (70.2%) women 297 (51.7%) professionals, whom 507 (85.1%) 283 (95.3%), respectively, were included...
Abstract Sex differences in endothelial cell (EC) biology may reflect intrinsic driven by chromosomes or sex steroid exposure and gender accumulated over life. We analysed EC gene expression data from boy–girl twins at birth non-twin adults to detect different stages of life, show that 14–25% the transcriptome is sex-biased. By combining both we identified are present maintained throughout those acquired Promisingly, found genes with an difference ECs more likely be targets steroids....
ABSTRACT Objective To propose a staging system for congenital lower urinary tract obstruction (LUTO) capable of predicting the severity condition and its prognosis. Methods This was national retrospective study carried out at eight Academic Hospitals in The Netherlands. We collected prenatal postnatal data fetuses high risk isolated LUTO that were managed conservatively. Postnatal renal function assessed by estimated glomerular filtration rate (eGFR), calculated using Schwartz formula,...
To develop a nationwide, evidence-based framework to support prenatal counseling in extreme prematurity, focusing on organization, decision-making, content, and style aspects.A nationwide multicenter RAND-modified Delphi method study was performed between November 2016 December 2017 the Netherlands. Firstly, recommendations were extracted from literature previous studies. Secondly, an expert panel (n = 21) with experienced parents, obstetricians, neonatologists rated importance for inclusion...