A5084438651- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Metabolism and Genetic Disorders
- Cardiac Arrest and Resuscitation
- Childhood Cancer Survivors' Quality of Life
- Family and Patient Care in Intensive Care Units
- Palliative Care and End-of-Life Issues
- Folate and B Vitamins Research
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- Emergency and Acute Care Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Congenital Diaphragmatic Hernia Studies
- Simulation-Based Education in Healthcare
- Respiratory Support and Mechanisms
- Gestational Diabetes Research and Management
- Child and Adolescent Health
- ATP Synthase and ATPases Research
- Delphi Technique in Research
- Airway Management and Intubation Techniques
- Diet and metabolism studies
- Neonatal Health and Biochemistry
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adolescent and Pediatric Healthcare
- Pregnancy and preeclampsia studies
Radboud University Nijmegen
2015-2024
Radboud University Medical Center
2015-2024
Amalia Kinderziekenhuis
2016-2024
University Medical Center
2019-2024
Radboud Institute for Molecular Life Sciences
2021-2023
Maastricht University
2019
University of Amsterdam
2019
Emma Kinderziekenhuis
2019
Vrije Universiteit Amsterdam
2019
University Medical Center Groningen
2019
<b>Background: </b> Based on a previous prospective clinical and biochemical study, consensus mitochondrial disease scoring system was established to facilitate the diagnosis in patients with suspected disorder. <b>Objective: To evaluate specificity of diagnostic system, we applied score 61 children multisystem oxidative phosphorylation disorder who underwent muscle biopsy were consecutively diagnosed genetic mutation. <b>Methods: We evaluated data 44 phosphorylation, carrying mutation or...
ContextShort-chain acyl-coenzyme A (CoA) dehydrogenase (SCAD) deficiency (SCADD) is an autosomal recessive, clinically heterogeneous disorder with only 22 case reports published so far. Screening for SCADD included in expanded newborn screening programs most US and Australian states.ObjectivesTo describe the genetic, biochemical, clinical characteristics of patients Netherlands their relatives to explore genotype phenotype relation.Design, Setting, ParticipantsRetrospective study involving...
<h3>Purpose:</h3> To identify the biochemical and molecular genetic defect in a 16-year-old patient presenting with apical hypertrophic cardiomyopathy neuropathy suspected for mitochondrial disorder. <h3>Methods:</h3> Measurement of energy-generating system (MEGS) capacity muscle enzyme analysis fibroblasts were performed. Relevant parts DNA analysed by sequencing. Transmitochondrial cybrids obtained fusion 143B206 TK<sup>−</sup> rho zero cells patient-derived enucleated fibroblasts....
Retention of resuscitation skills is usually assessed at a predefined moment, which enables participants to prepare themselves, possibly introducing bias. In this multicenter study, we evaluated the retention knowledge and in pediatric basic life support (PBLS) amongst 58 pediatricians residents with an unannounced examination. Practical PBLS were validated scoring instrument, theoretical 10-item multiple-choice test (MCQ). Participants self-assessed their capabilities using five-point...
To develop a nationwide, evidence-based framework to support prenatal counseling in extreme prematurity, focusing on organization, decision-making, content, and style aspects.A nationwide multicenter RAND-modified Delphi method study was performed between November 2016 December 2017 the Netherlands. Firstly, recommendations were extracted from literature previous studies. Secondly, an expert panel (n = 21) with experienced parents, obstetricians, neonatologists rated importance for inclusion...
Background: Cobalamin (Cbl) deficiency is a common clinical phenomenon, in particular among the elderly and possibly also infants. Methylmalonic acid (MMA) most sensitive specific marker of intracellular Cbl status, but its application hindered by limited methods available for accurate high-throughput MMA determination.
Decisions at the limits of viability about initiating care are challenging. We aimed to investigate physicians' preferences on treatment decisions, against background 2010 Dutch guideline offering active from 24+0/7 weeks gestational age (GA). Obstetricians' and neonatologists' opinions were compared. An online survey was conducted amongst all perinatal professionals (n = 205) 10 level III centers. Response rate 60 % 122). Comfort mostly recommended below intensive over 26+0/7 weeks. The...
<b><i>Introduction:</i></b> Laryngeal mask airway (LMA) use in neonatal resuscitation is limited despite existing evidence and recommendations. This survey investigated the knowledge experience of healthcare providers on LMA explored barriers solutions for implementation. <b><i>Methods:</i></b> online, cross-sectional involved professionals Union European Neonatal Perinatal Societies (UENPS). <b><i>Results:</i></b> A...
While game-based learning has demonstrated positive outcomes for some learners, its efficacy remains variable. Adaptive scaffolding may improve performance and self-regulation during training by optimizing cognitive load. Informed load theory, this study investigates whether adaptive based on interaction trace data influences performance, self-regulation, load, test engagement in a medical emergency game.
Background. Video-assisted real-time simulation (VARS) offers the possibility of developing competence in acute medicine a realistic and safe environment. We investigated effectiveness VARS model compared it with educational methods like Problem-Based Learning (PBL) Pediatric Advanced Life Support (PALS). Methods. 45 fourth-year medical students were randomized for three methods. Level knowledge self-efficacy measured before after intervention. Clinical performance was by blinded observer...
Since 2010, intensive care can be offered in the Netherlands at 24+0 weeks gestation (with parental consent) but Dutch guideline lacks recommendations on organization, content and preferred decision-making of counselling. Our aim is to explore prenatal counselling limits viability by perinatal professionals compare this current care.Online nationwide survey as part PreCo study (2013) amongst obstetricians neonatologists all level III centers (n = 205).The regarded focused domains both...
To investigate the main factors which facilitate or hinder end-of-life decision-making (EoLDM) in neonates and children.
To identify parents' information needs about impending very preterm birth and compare these to current practices in the Netherlands.
Prenatal counseling at the threshold of viability is a challenging yet critically important activity, and care guidelines differ across cultures. Studying how this task performed in actual clinical environment extremely difficult. In pilot study, we used simulation as methodology with 2 aims follows: first, to explore use incorporating standardized pregnant patient an investigative and, second, determine similarities differences content style prenatal between American Dutch neonatologists.We...