A5061720639- Neonatal Respiratory Health Research
- Central Venous Catheters and Hemodialysis
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Childhood Cancer Survivors' Quality of Life
- Child Abuse and Related Trauma
- Gene Regulatory Network Analysis
- Lymphatic Disorders and Treatments
- Streptococcal Infections and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Operations and Scheduling Optimization
- Gastroesophageal reflux and treatments
- Palliative Care and End-of-Life Issues
- Assisted Reproductive Technology and Twin Pregnancy
- Genomic variations and chromosomal abnormalities
- Modeling and Simulation Systems
- Renal and related cancers
Radboud University Nijmegen
2010-2025
Radboud University Medical Center
2010-2025
Amalia Kinderziekenhuis
2018-2025
Radboud Institute for Molecular Life Sciences
2022-2023
Creative Commons
2022
In preterm neonates the immune system is thought to be less developed at birth, but very little known about actual size of lymphocyte subpopulations, and even maturation these subpopulations during first months after a premature birth. To evaluate development in infants 3 we performed prospective longitudinal study two hospitals Netherlands. Preterm (n = 38) all post-menstrual ages were included blood samples taken from cord blood, 1 week, 6 weeks, months. Lymphocyte measured by four-colour...
Abstract Neonatology care, the care for premature and severely ill babies, is increasingly confronted with capacity challenges. The entire perinatal chain, including Neonatal Intensive Care Unit (NICU), operates at high occupation levels. This results in refusals, leading to undesirable transports other centers or even abroad, which affects quality of length stay, safety these places a heavy burden on patients, their families, involved caregivers. In this work we assess improvement potential...
Abstract Congenital diaphragmatic hernia (CDH) is a disorder of the development lung and diaphragm associated with pulmonary hypoplasia hypertension. Denys–Drash syndrome (DDS) well‐known caused by several different germline mutations in WT1‐gene. CDH DDS rare. We present third case clinical features same, rare Arg366His mutation WT1‐gene, as reported other two known cases. This report provides additional evidence that WT1 can result hernia. © 2008 Wiley‐Liss, Inc.
<i>Background:</i> Congenital chylothorax (CC) is a severe congenital disorder characterized by the collection of chyle in pleural space. Recent case reports suggest that use octreotide treatment CC may be useful. <i>Objective:</i> To evaluate effect on effusions CC. <i>Methods:</i> Hospital records 7 patients with CC, who were admitted to Neonatal Intensive Care Unit Radboud University Nijmegen Medical Centre between 2006 and 2010 treated octreotide,...
Prenatal counseling at the threshold of viability is a challenging yet critically important activity, and care guidelines differ across cultures. Studying how this task performed in actual clinical environment extremely difficult. In pilot study, we used simulation as methodology with 2 aims follows: first, to explore use incorporating standardized pregnant patient an investigative and, second, determine similarities differences content style prenatal between American Dutch neonatologists.We...
Wolf-Hirschhorn syndrome is characterized by severe growth and mental retardation, microcephaly, seizures 'Greek helmet' facies, caused partial deletion of the short arm chromosome 4. Growth charts are given from 0-4 years age, based on study 101 individuals. Use these specific recommended, because standard inapplicable for patients with WHS.
There has been no evidence to show whether care bundles of preventive measures reduce central line-associated bloodstream infection (CLABSI) in peripherally inserted catheters using the modified Seldinger technique, which requires more specific skills than traditional technique. The aim this study was address that gap our knowledge and determine other variables influenced outcome.This prospective observational conducted on a neonatal intensive unit. We observed incidence CLABSI 45 newborn...
The Newborn Life Support (NLS) guideline aims to provide healthcare professionals a consistent approach during neonatal resuscitation. Adherence this and analogous guidelines has repetitively been proven be difficult.This study evaluates adherence using novel augmented reality (Microsoft HoloLens) electronic decision support tool standardized simulated resuscitation compared with subjects working from memory alone.In randomized controlled pilot study, 18 responsible for were the intervention...
Central line-associated bloodstream infections (CLABSI) are a main focus of infection prevention and control initiatives in neonatal care. Standardised surveillance CLABSI enables intra- interfacility comparisons which can contribute to quality improvement. To date, there is no national registration system for care the Netherlands several criteria used local monitoring incidence rates. achieve standardised we conducted consensus procedure with regard nationwide (SC). A modified Delphi...
The establishment of an epidemiological overview provides valuable insights needed for the (future) dissemination infection-prevention initiatives.
Acute care providers intervening on fragile patients face many knowledge and information related challenges. Explanation based causal chains of events has limitations when applied to complex physiological systems, model-driven educational software may overwhelm the learner with information. We introduce a new concept technology facilitate understanding, reasoning, communication in clinical environment. The aim is grasp physiology more intuitive way. An EM representation relevant physiologic...
Maintaining an optimal acid base is important for the patient. The theory underlying acid-base balance can be challenging clinicians and educators. These considerations justify creating simulations that include realistic changes to partial pressure of carbon dioxide, pH, bicarbonate ion concentration in a range conditions. Our explanatory simulation application requires model derives these variables from total dioxide content runs real time. presented derived Stewart model, which based on...