A5046085286- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Congenital Diaphragmatic Hernia Studies
- Blood disorders and treatments
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Congenital Anomalies and Fetal Surgery
- Ectopic Pregnancy Diagnosis and Management
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- Blood transfusion and management
- Central Venous Catheters and Hemodialysis
- Neonatal and Maternal Infections
- Birth, Development, and Health
- Respiratory Support and Mechanisms
- Retinopathy of Prematurity Studies
- Parvovirus B19 Infection Studies
- Airway Management and Intubation Techniques
Leiden University Medical Center
2016-2025
Leiden University
2016-2025
Loyola University Medical Center
2014-2021
University Medical Center Groningen
2013-2019
University of Groningen
2019
Sanquin
2012-2018
Willem-Alexander Kinderziekenhuis
2013-2018
John Wiley & Sons (United Kingdom)
2018
Hudson Institute
2018
Pediatrics and Genetics
2007-2017
Platelet transfusions are commonly used to prevent bleeding in preterm infants with thrombocytopenia. Data lacking provide guidance regarding thresholds for prophylactic platelet neonates severe thrombocytopenia.In this multicenter trial, we randomly assigned born at less than 34 weeks of gestation whom thrombocytopenia developed receive a transfusion platelet-count 50,000 per cubic millimeter (high-threshold group) or 25,000 (low-threshold group). Bleeding was documented prospectively the...
In early-onset severe hemolytic disease of the fetus and newborn (HDFN), transplacental transfer maternal antierythrocyte IgG alloantibodies causes fetal anemia that leads to use high-risk intrauterine transfusions in order avoid hydrops death. Nipocalimab, an anti-neonatal Fc receptor blocker, inhibits lowers levels.
Objectives Thrombocytopenia is a frequent problem in neonatal sepsis and among the most predictive, independent risk factors for sepsis-associated mortality. This study aims to clarify occurrence, severity duration of thrombocytopenia sepsis. Study design A cohort was carried out all neonates with proven culture positive that were admitted tertiary NICU between 2006 2015 (n = 460). The recorded, as well major bleedings potential mortality Results Sepsis diagnosed 460 6551 (7%). Severe...
<b>Objective</b> To determine women's satisfaction with pain relief using patient controlled analgesia remifentanil compared epidural during labour. <b>Design</b> Multicentre randomised equivalence trial. <b>Setting</b> 15 hospitals in the Netherlands. <b>Participants</b> Women an intermediate to high obstetric risk intention deliver vaginally. exclude a clinically relevant difference of more than 10%, we needed include 1136 women. Because missing values for this number was increased 1400...
Monochorionic twins share a single placenta and are connected with each other through vascular anastomoses. Unbalanced inter-twin blood transfusion may lead to various complications, including twin-to-twin syndrome (TTTS) twin anemia polycythemia sequence (TAPS). TAPS was first described less than decade ago, the pathogenesis of results from slow donor recipient few minuscule This gradually leads in recipient, absence oligo-polyhydramnios (TOPS). occur spontaneously 3-5% monochorionic or...
To investigate the diagnostic accuracy of delta middle cerebral artery peak systolic velocity (MCA-PSV) > 0.5 multiples median (MoM) and compare its predictive value with that current MCA-PSV cut-off values 1.5 MoM in donor < 1.0 recipient, for diagnosis twin anemia-polycythemia sequence (TAPS) monochorionic pregnancy.This was a retrospective consecutive cohort study comprising all uncomplicated pregnancies postnatal TAPS managed between 2003 2017 Dutch national referral center fetal...
Assess mortality and neurodevelopmental outcomes at 2 years of corrected age in children who participated the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion - 2/Management Thrombocytopenia Special Subgroup) study, which reported that a higher platelet transfusion threshold was associated with significantly increased or major bleeding compared to lower one.Randomised clinical trial, enrolling from June 2011 August 2017. Follow-up complete by January 2020. Caregivers were not blinded;...
Background Preterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe compare our findings three recent randomised controlled trials understand how clinical practice relates the trial data. Methods From October December 2020, we performed an online among 597 neonatal intensive care units (NICUs) caring for with a gestational age (GA)...
Substandard or disrespectful care during labour should be of serious concern for healthcare professionals, as it can affect one the most important events in a woman's life. refers to use interventions that are not considered best-practice, inadequate execution interventions, situations where best-practice withheld from patients, there is lack adequate informed consent. Disrespectful forms verbal and non-verbal communication patients' dignity, individuality, privacy, intimacy, personal...
Objective To describe the outcome of pregnancies with fetal and neonatal alloimmune thrombocytopenia (FNAIT) in relation to invasiveness management protocol. Design Retrospective analysis prospectively collected data from a national cohort. Setting Leiden University Medical Centre, centre for severe red cell platelet alloimmunisation pregnancy. Population Ninety‐eight 85 women FNAIT having previous child ( n = 16) or without 82) an intracranial haemorrhage (ICH). Methods Our protocol evolved...
In Brief OBJECTIVE: To estimate the risk factors for adverse long-term neurodevelopment outcome in twin–twin transfusion syndrome treated with laser surgery. METHODS: Twin–twin cases surgery at three European centers from August 2000 to December 2005 were included this case-control study. Neurological, mental, and psychomotor development (using Bayley Scales of Infant Development, 2nd edition) was evaluated 2 years age. RESULTS: A total 212 pregnancies during study period. Overall mortality...
In Brief OBJECTIVE: To study perinatal mortality and neonatal morbidity in a large cohort of monoamniotic twin pregnancies with special emphasis to the gestational age-specific mortality. METHODS: The included delivered 10 centers Netherlands between January 2000 December 2007. RESULTS: A total 98 were included. rate (20 weeks gestation through 28 days life) was 19%; after exclusion fetuses lethal anomalies, 17%. After 32 gestation, only two complicated by (4%). incidence twin–twin...
In Brief OBJECTIVE: To study the placental angioarchitecture of monochorionic placentas with and without twin anemia–polycythemia sequence. METHODS: Eligible were all from gestations, not complicated by twin-to-twin transfusion syndrome resulting in double survival. The was conducted at two European Fetal Therapy Centers between 2002 2008. Placental evaluated using colored dye injection. Diagnosis sequence based on presence large intertwin hemoglobin difference degree amniotic fluid...