A5006626732- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Infectious Diseases and Mycology
- Genetic and rare skin diseases.
- Tumors and Oncological Cases
- Reconstructive Facial Surgery Techniques
- Hedgehog Signaling Pathway Studies
- Skin and Cellular Biology Research
- Genital Health and Disease
- Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Sarcoma Diagnosis and Treatment
- Nail Diseases and Treatments
- COVID-19 and healthcare impacts
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- Oral and Maxillofacial Pathology
- Cervical Cancer and HPV Research
- Vascular Tumors and Angiosarcomas
- Molecular Biology Techniques and Applications
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
Universitat de Barcelona
1998-2025
Hospital Clínic de Barcelona
2000-2025
Universitat Autònoma de Barcelona
2005-2024
Hospital Del Mar
2015-2024
Hospital del Mar Research Institute
2012-2023
Municipal Institute for Medical Research
2010-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2002-2023
Instituto de Salud Carlos III
2016-2023
Centre for Biomedical Network Research on Rare Diseases
2021-2023
RELX Group (United States)
2023
Activating mutations of the p110 alpha subunit PI3K (PIK3CA) oncogene have been identified in a broad spectrum malignant tumors. However, their role benign or preneoplastic conditions is unknown. FGF receptor 3 (FGFR3) are common skin lesions, either as embryonic epidermal nevi (EN) somatic seborrheic keratoses (SK). FGFR3 also low-grade bladder tumors, where they often occur association with PIK3CA mutations. Therefore, we examined exons 9 and 20 hotspot EN (n = 33) SK 62), two...
<h3>Background</h3> Activating <i>RAS</i> mutations in the germline cause rare developmental disorders such as Costello syndrome. Somatic are found approximately 30% of human cancers. Keratinocytic epidermal nevi (KEN) represent benign congenital skin lesions arranged along Blaschko9s lines. A subgroup KEN is caused by hotspot oncogenic <i>FGFR3</i> and <i>PIK3CA</i> mosaicism, but majority lack these mutations. <h3>Methods</h3> This study screened 72 for activating genes other oncogenes....
Abstract Dermatofibrosarcoma protuberans (DFSP) is characterized by the presence of t(17;22)(q22;q13) that leads to fusion COL1A1 and PDGFB genes. This translocation can be detected multiplex reverse transcriptase‐polymerase chain reaction (RT‐PCR) or fluorescence in situ hybridization (FISH) techniques. We have evaluated usefulness a dual color FISH probe strategy for COL1A1/PDGFB detection series 103 archival DFSPs compared obtained results with RT‐PCR analyses. were carried out on...
Malignant tumors result from the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Much less is known about changes benign tumors. Seborrheic keratoses (SK) are very frequent human epidermal without malignant potential. We performed a comprehensive mutational screen genes FGFR3-RAS-MAPK phosphoinositide 3-kinase (PI3K)-AKT pathways 175 SK, including multiple lesions each patient. SK commonly harbored bona fide oncogenic mutations FGFR3 , PIK3CA, KRAS HRAS EGFR AKT1...
Data on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well their relationship with severity COVID-19 are limited.Retrospective analysis a prospectively collected cohort patients infection in teaching hospital Barcelona, Spain, from 1 April to May 2020. Clinical, microbiological therapeutic characteristics, clinicopathological direct immunofluorescence immunohistochemical findings biopsies were analyzed.Fifty-eight out 2761 (2.1%) either consulting emergency...
Cutaneous squamous cell carcinoma (cSCC) is the second most common subtype of skin cancer. The scalp one frequently affected locations and associated with a higher rate complications, compared to other locations. In addition, it has characteristic thickness anatomical structure that may influence both growth pattern treatment primary cSCC; while clinical peripheral margins be easily achieved during surgery, vertical excision tumor limited by skull. Despite having unique anatomy, current...
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and frequently progresses from an actinic keratosis (AK), a sun-induced keratinocyte intraepithelial neoplasia (KIN). Epigenetic mechanisms involved in phenomenon of progression AK to cSCC remain be elicited. Expression microRNAs sun-exposed skin, was analysed by Agilent microarrays. DNA methylation miR-204 promoter determined bisulphite treatment pyrosequencing. Identification targets pathways accomplished HaCat...
The genetic alterations that drive the transition from actinic keratoses (AKs) to cutaneous squamous cell carcinomas (SCCs) have not been defined precisely. Amplification and/or overexpression of MYC proto-oncogene demonstrated in several human, malignant tumours including head and neck SCCs.To evaluate presence genomic aberrations both AKs SCCs.Skin biopsy specimens corresponding AKs, SCCs control samples were included two paraffin-embedded tissue microarrays. cytogenetic profile was...
No AccessJournal of UrologyInvestigative Urology1 Dec 2013mTOR Signaling Pathway in Penile Squamous Cell Carcinoma: pmTOR and peIF4E Over Expression Correlate with Aggressive Tumor Behavior Carla Ferrandiz-Pulido, Emili Masferrer, Agustin Toll, Javier Hernandez-Losa, Sergio Mojal, Ramon M. Pujol, Santiago y Cajal, Ines de Torres, Vicente Garcia-Patos Ferrandiz-PulidoCarla Ferrandiz-Pulido Department Dermatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain Facultat Medicina,...
Abstract: Programmed cell death ligand 1 (PD-L1) expression by tumor cells plays an important role in the inhibition of T cell–mediated immune response cancer. PD-L1 has been linked to poor prognosis a wide variety cancers. However, cutaneous squamous carcinoma (cSCC) scarcely studied, and its as biomarker remains controversial. The association metastatic risk series cSCC was assessed. CD8 immunostainings full excision sections 99 primary tumors 24 lymphatic metastases were...
The aim of this study was to compare tumour burden in patients who underwent surgery for melanoma and cutaneous squamous cell carcinoma during nationwide lockdown Spain due COVID-19 (for the period 14 March 13 June 2020) same dates 2019 before pandemic. In addition, associations between median (Breslow thickness maximum clinical diameter carcinoma) demographic, clinical, medical factors were analysed, building a multivariate linear regression model. During 3 months lockdown, there...
Dermoscopy is a useful tool for dermatologists to study melanocytic lesions. Its possible usefulness in the assessment of capillary nailfold morphological changes (capillaroscopy) has recently been advocated.To assess practical utility digital epiluminescence microscopy as capillaroscopic instrument patients with Raynaud phenomenon (RP). To compare sensitivity and specificity rates obtained by those previously reported conventional devices.Fifty-six consecutive primary RP (PRP; n = 5) or...
Background Oncogenesis in the oral cavity is believed to result from genetic alterations that cause a stepwise transformation of mucosa invasive carcinoma. In squamous cell carcinoma (OSCC) multiple cytogenetic abnormalities have been reported, but their practical significance remains uncertain. Objective To evaluate usefulness assessment CCND1, MYC, EGFR, ERBB2 and TP53 OSCC lymph node metastases. Methods Fifty-one consecutive samples OSCC, nine biopsies showing metastatic spread 16...