A5103031432- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Pancreatitis Pathology and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Digestive system and related health
- Neuroendocrine Tumor Research Advances
- Molecular Biology Techniques and Applications
- Metastasis and carcinoma case studies
- Renal and related cancers
- Gastrointestinal motility and disorders
Centro de Investigación Biomédica en Red de Cáncer
2018-2025
Hospital Del Mar
2016-2025
Parc de Salut
2011-2025
Universitat Pompeu Fabra
2003-2025
Hospital del Mar Research Institute
2012-2024
Municipal Institute for Medical Research
2009-2024
Universitat Autònoma de Barcelona
2012-2023
University of Amsterdam
2023
Amsterdam University Medical Centers
2023
Cancer Center Amsterdam
2023
BackgroundRAS assessment is mandatory for therapy decision in metastatic colorectal cancer (mCRC) patients. This determination based on tumor tissue, however, genotyping of circulating (ct)DNA offers clear advantages as a minimally invasive method that represents heterogeneity. Our study aims to evaluate the use ctDNA an alternative determining baseline RAS status and subsequent monitoring mutations during component routine clinical practice.Patients methodsRAS mutational plasma was...
To compare perioperative outcomes of pancreatoduodenectomy (PD) performed through the laparoscopic route or by open surgery.Laparoscopic PD is being progressively in selected patients.An open-label single-center RCT was conducted between February 2013 and September 2017. The primary endpoint length hospital stay (LOS). Secondary endpoints were operative time, transfusion requirements, specific pancreatic complications (pancreatic biliary fistula, hemorrhage, delayed gastric emptying),...
Abstract Purpose: Patients with colorectal cancer who respond to the anti-EGFR antibody cetuximab often develop resistance within several months of initiating therapy. To design new lines treatment, molecular landscape resistant tumors must be ascertained. We investigated role mutations in EGFR signaling axis on acquisition patients and cellular models. Experimental Design: Tissue samples were obtained from 37 became refractory cetuximab. Colorectal cells sensitive treated until derivatives...
Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory B disseminated throughout the intestine but rare systemic lymphoid organs. In addition sharing gut-specific gene signature with IgA+ cells, some clonotypes switched IgA response T cell-independent or cell-dependent signals. These signals induced IgM...
The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking.In this international non-inferiority trial, we recruited adults from 35 centres 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) open (ODP). Both and pathologists blinded approach. Primary endpoint was...
Abstract A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence drug resistance. Here, we apply elemental imaging mapping CT biodistribution after therapy in residual colorectal and achieve a comprehensive analysis genetic program induced by oxaliplatin-based tumor microenvironment. We show that oxaliplatin is largely retained cancer-associated fibroblasts (CAFs) long time treatment ceased. determine accumulation CAFs intensifies...
Previous studies have highlighted the importance of an appropriate human epidermal growth factor receptor 2 (HER2) evaluation for proper identification patients eligible treatment with anti-HER2 targeted therapies. Today, relationship remains unclear between level HER2 amplification and outcome HER2-positive gastric cancer treated first-line chemotherapy trastuzumab. The aim this study was to determine whether gene determined by HER2/CEP17 ratio copy number could significantly predict some...
Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance standard therapies. A more comprehensive understanding complexity PDA pathobiology, especially role microenvironment in disease progression, should pave way for therapies improve patient response rates. In this study, we identify galectin-1 (Gal1), a glycan-binding protein that is highly overexpressed stroma, as major driver pancreatic...
Despite some advances, pancreatic ductal adenocarcinoma (PDAC) remains generally refractory to current treatments. Desmoplastic stroma, a consistent hallmark of PDAC, has emerged as major source therapeutic resistance and thus potentially promising targets for improved treatment. The glycan-binding protein galectin-1 (Gal1) is highly expressed in PDAC but its roles there have not been studied. Here we report functions molecular pathways Gal1 that mediate oncogenic properties this setting....
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss intestinal stem cells (ISCs). However, whether effect Notch is direct due to aberrant differentiation transit-amplifying into post-mitotic goblet unknown. To address this issue, we have generated composite tamoxifen-inducible intestine-specific genetic mouse models and analyzed expression markers. Importantly, found activation β-catenin partially rescues phenotype Rbpj deletion mutants, but not...
Recent studies suggest potential roles of the endocannabinoid system in gastrointestinal inflammation. Although cannabinoid CB(2) receptor expression is increased inflammatory disorders, presence and function remaining proteins colonic tissue not well characterized.Cannabinoid CB(1) receptors, enzymes for biosynthesis DAGLalpha, DAGLbeta NAPE-PLD, endocannabinoid-degradating FAAH MAGL were analysed both acute untreated active ulcerative pancolitis treated quiescent patients comparison with...
Over-expression of Snail1 gene transcriptional repressor promotes an epithelial-to-mesenchymal transition in epithelial tumour cell lines. Expression RNA has been associated to the pathogenesis a number malignancies; however, lack good monoclonal antibodies against this protein precluded definitive analysis protein. In study, we aimed determine expression factor colorectal tumours. Using well-characterized antibody developed our laboratories have analyzed by immunohistochemistry cohort 162...
Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that induced by MAP kinases BRAF and TAK1 promotes tumor growth independent canonical NF-κB signaling. Insights into sources activation its downstream substrates in nucleus remain to be defined. Here, we discover rapidly activated DNA damage ATM-ATR, but dependent on BRAF-TAK1-p38-MAPK, required for robust ATM efficient repair. Abolishing or activity attenuates ATM, Chk1, MDC1, Kap1, 53BP1 phosphorylation, compromises RIF1...
Approved anti-EGFR antibodies cetuximab and panitumumab provide significant clinical benefit in patients with metastatic colorectal cancer (MCRC). However, ultimately develop disease progression, often driven by acquisition of mutations the extracellular domain (ECD) EGFR. Sym004 is a novel 1:1 mixture two nonoverlapping mAbs that recently showed promising activity phase I trial MCRC. Our aim was to determine efficacy circumvent resistance EGFR ECD mutations.Functional studies were performed...
Abstract Background: Despite smoking being a well-established risk factor for pancreatic cancer, there is need to further characterize cancer according lifespan patterns and other features, such as tobacco type. Our aim was deeply investigate them within large European case–control study. Methods: Tobacco habits relevant information were obtained from 2,009 cases 1,532 controls recruited in the PanGenEU study using standardized tools. Multivariate logistic regression analysis performed...
Objectives To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing (LSDM)) and pancreatic cancer (PC) risk, to explore direction of causation through Mendelian randomisation (MR) analysis assess mediation role body mass index (BMI). Design Information about related factors was collected from 2018 PC cases 1540 controls PanGenEU (European Study into Digestive Illnesses Genetics) study. A subset had glycated haemoglobin,...