A5069359188- Analytical chemistry methods development
- Mass Spectrometry Techniques and Applications
- Laser-induced spectroscopy and plasma
- Ion-surface interactions and analysis
- Marine and fisheries research
- Mercury impact and mitigation studies
- Analytical Chemistry and Sensors
- Fish Ecology and Management Studies
- Isotope Analysis in Ecology
- Fish biology, ecology, and behavior
- Fish Biology and Ecology Studies
- Advanced Chemical Sensor Technologies
- Semiconductor materials and devices
- Ichthyology and Marine Biology
- Archaeological and Historical Studies
- Archaeological and Geological Studies
- Metal and Thin Film Mechanics
- Analytical Chemistry and Chromatography
- Plasma Diagnostics and Applications
- Electrochemical Analysis and Applications
- Cultural Heritage Materials Analysis
- Diamond and Carbon-based Materials Research
- Medieval Architecture and Archaeology
- Coral and Marine Ecosystems Studies
- Laser Material Processing Techniques
Universidad de Oviedo
2016-2025
ETH Zurich
2005-2008
École Polytechnique Fédérale de Lausanne
2006
Abstract A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence drug resistance. Here, we apply elemental imaging mapping CT biodistribution after therapy in residual colorectal and achieve a comprehensive analysis genetic program induced by oxaliplatin-based tumor microenvironment. We show that oxaliplatin is largely retained cancer-associated fibroblasts (CAFs) long time treatment ceased. determine accumulation CAFs intensifies...
Inorganic mass spectrometric techniques and methods for direct solid analysis are widely required to obtain valuable information about the multi-elemental spatial distribution of major trace constituents and/or isotope ratio a sample in wide variety specimens, including environmental wastes, biological samples, geochemical materials, coatings semiconductors. The increasing need characterize complex materials industry (e.g. production control quality assurance processes), different fields...
The analytical figures of merit ultra-violet femtosecond laser ablation inductively coupled plasma mass spectrometry (UV-fs-LA-ICP-MS) using the 3rd and 4th harmonics Ti:Sapphire (∼265 ∼200 nm, respectively) were explored. For this purpose, elemental ratios aerosols produced by LA silicate glass (SRM NIST 610) studied under varying fluence conditions ranging from moderate values 2 J cm−2 up to 30 cm−2, taking into account e.g. laser-induced (66Zn/65Cu) particle size-related (238U/232Th)...
This review covers advances in atomic spectrometric techniques, including emission, absorption, fluorescence and mass spectrometry. Material on speciation coupled techniques is not covered as this included a separate ASU review.
The analytical potential of a nanosecond laser ablation inductively coupled plasma mass spectrometer system, equipped with an ultra-fast wash-out chamber, is critically investigated for fast and highly spatially resolved (∼μm) qualitative elemental distribution within single cells.
By combining a convolutional neural network (CNN) and laser induced breakdown spectroscopy, this study reports multi-task analysis method to simultaneously solve the problems of lithological recognition quantitative seven major chemical elements in rock analysis.
The relative success of platinum (Pt)-based chemotherapy comes at the cost severe adverse side effects and is associated with a high risk pro-oncogenic activation in tumor microenvironment. Here, we report synthesis C-POC, novel Pt(IV) cell-penetrating peptide conjugate showing reduced impact against nonmalignant cells. In vitro vivo evaluation using patient-derived organoids laser ablation inductively coupled plasma mass spectrometry indicates that C-POC maintains robust anticancer efficacy...
The quantification capabilities of iron-based samples were investigated using three commercially available ultraviolet (UV) nanosecond (ns) and femtosecond (fs) laser ablation systems coupled to inductively plasma mass spectrometry (LA-ICP-MS). A comparison pulsed (ArF* excimer, Nd:YAG Ti-sapphire) with different wavelengths pulse time durations (15 ns, 4 ns 150 fs, respectively) was performed. Minor trace elements determined 57Fe as internal standard element. Using similar spatial...
Direct solid analysis of bulk and thin coated glasses by pulsed radiofrequency (rf) glow discharge time-of-flight mass spectrometry (GD-TOFMS) is investigated. Modulated low pressure plasma created pulsed-rf-GD has been coupled to a fast TOFMS in order obtain complete spectra information from the different GD pulse domains (pre-peak, plateau afterglow). In particular, it was observed that analytes show highest atomic ion signals afterglow region some hundred microseconds after maximum Ar...
This review covers developments in 'Atomic Spectrometry'. It atomic emission, absorption, fluorescence and mass spectrometry, but excludes material on speciation coupled techniques which is included a separate review. should be read conjunction with the other related reviews series.1–6 A critical approach to selection of has been adopted, only novel instrumentation, methodology being included. Developments worthy note include photochemical electrochemical methods vapour generation, single...
The application of a new methodology for direct solid analysis fluorine by LIBS is evaluated. This approach, based on the nebulization Ca solution over fluorine-containing sample, allows F quantification using emission CaF molecular bands.
LA-ICP-MS has been used for the first time to study simultaneous elemental quantitative distribution of Ca, Fe, Cu and Zn in breast cancer samples.
This review covers advances in atomic spectrometric techniques, including emission, absorption, fluorescence and mass spectrometry. Material on speciation coupled techniques is not covered as this included a separate ASU review.
A novel ablation cell for laser inductively coupled plasma mass spectrometry (LA-ICP-MS) was developed. The "high efficiency aerosol dispersion" (HEAD) is based on the use of a directed gas flow expansion generated at site and venturi effect created by two nozzles to extract into main make up stream, which finally transports particles ICP. figures merit were evaluated glass SRM NIST 610 using different gases (Ar He). investigation capabilities this type extraction (using Nd:YAG laser, λ =...
The capabilities of ultraviolet femtosecond laser ablation inductively coupled plasma mass spectrometry (UV-fs-LA-ICPMS) for depth profile analysis thin metal coatings were evaluated. A standard sample consisting a single Cr layer 500 nm ± 5% on Ni substrate was used. fast washout obtained by high-efficiency aerosol dispersion cell (V ∼1 cm3), which allowed single-shot with increased resolution. Laser performed in helium at atmospheric pressure conditions. repetition rate 1 Hz and low...
The analytical potential of a radiofrequency glow discharge orthogonal time-of-flight mass spectrometer (RFGD-TOFMS) has been evaluated in both pulsed and non-pulsed modes. A certified reference steel was selected for this study. operating conditions the GD plasma (pressure applied power) were optimized terms sensitivity. Additionally, duty cycle pulse width parameters investigated RF mode. In case, high analyte ion signals improved signal to background ratios measured after end pulse,...
Despite the importance of diatoms in regulating climate and existence large opal-containing sediments key air-ocean exchange areas, most geochemical proxy records are based on carbonates. Among them, Boron (B) content isotopic composition have been widely used to reconstruct pH from foraminifera coral fossils. We assessed possibility a pH/CO2 seawater concentration control B diatom opal determine whether or not frustule concentrations could be as clarify algae physiological responses...