A5091534163- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Vascular Tumors and Angiosarcomas
- Ferroptosis and cancer prognosis
- Tumors and Oncological Cases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- Viral-associated cancers and disorders
- Colorectal Cancer Surgical Treatments
- CNS Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Innovations in Medical Education
- Medical Imaging and Pathology Studies
INCLIVA Health Research Institute
2016-2025
Instituto de Salud Carlos III
2019-2025
Centro de Investigación Biomédica en Red de Cáncer
2019-2025
Universitat de València
2014-2025
Hospital Clínico Universitario de Valencia
2016-2025
Biomedical Research Institute
2018-2023
In-Q-Tel
2016
BackgroundA high percentage of patients diagnosed with localized colon cancer (CC) will relapse after curative treatment. Although pathological staging currently guides our treatment decisions, there are no biomarkers determining minimal residual disease (MRD) and at risk being undertreated or even overtreated chemotherapy in this setting. Circulating-tumor DNA (ctDNA) can to be a useful tool better detect relapse.Patients methodsOne hundred fifty CC were prospectively enrolled study. Tumor...
Abstract A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence drug resistance. Here, we apply elemental imaging mapping CT biodistribution after therapy in residual colorectal and achieve a comprehensive analysis genetic program induced by oxaliplatin-based tumor microenvironment. We show that oxaliplatin is largely retained cancer-associated fibroblasts (CAFs) long time treatment ceased. determine accumulation CAFs intensifies...
Abstract About 50% of human epidermal growth factor receptor 2 (HER2)+ breast cancer patients do not benefit from HER2-targeted therapy and almost 20% them relapse after treatment. Here, we conduct a detailed analysis two independent cohorts HER2+ treated with trastuzumab to elucidate the mechanisms resistance anti-HER2 monoclonal antibodies. In addition, develop fully humanized immunocompetent model recapitulating ex vivo biological processes that associate patients’ response Thanks these...
Patient-derived organoids (PDOs) from advanced colorectal cancer (CRC) patients could be a key platform to predict drug response and discover new biomarkers. We aimed integrate PDO with multi-omics characterization beyond genomics.We generated 29 lines 22 CRC provided morphologic, genomic, transcriptomic characterization. performed sensitivity assays panel of both standard non-standard agents in five long-term cultures, integrated baseline proteomic by SWATH-MS RNA-seq analysis,...
Abstract Purpose: Despite the clinical advantage of combination trastuzumab and platinum-based chemotherapy in HER2-amplified tumors, resistance will eventually develop. The identification molecular mechanisms related to primary acquired is needed. Experimental Design: We generated lapatinib- trastuzumab-resistant clones deriving from two different gastric cancer cell lines. Molecular changes such as protein expression gene-expression profile were evaluated detect alterations that could be...
Tertiary lymphoid structures (TLSs) are thought to stimulate antitumor immunity and positively impact prognosis response immune checkpoint blockade. In gastric cancers (GCs), however, TLSs predominantly found in GC with poor limited treatment response. We, therefore, hypothesize that cell composition function of TLS depends on tumor location the environment.
Immune effector cell-associated neurotoxicity syndrome (ICANS) is common after chimeric antigen receptor T-cell (CAR-T) therapy. Objective. This study aimed to assess the impact of preinfusion electroencephalography (EEG) abnormalities and EEG findings at ICANS onset for predicting risk severity in 56 adult patients with refractory lymphoma undergoing CAR-T Study design. EEGs were conducted time lymphodepleting chemotherapy shortly ICANS. Results. Twenty-eight (50%) developed a median 6 days...
BackgroundThe molecular classification of gastric cancer recognises two subtypes prone to immune checkpoint blockade: the microsatellite unstable and Epstein-Barr virus (EBV)-related tumours. We aim assess concordance between immunohistochemistry PCR for status evaluation, explore value instability (MSI) EBV as predictive survival factors.Material methodsWe collected 246 consecutively diagnosed cases in all stages evaluated using mismatched repair (MMR) proteins PCR. expression was studied...
Abstract Introduction Gastric cancer (GC) burden is currently evolving with regional differences associated complex behavioural, environmental, and genetic risk factors. The LEGACy study a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal from European LATAM countries. Material methods Treatment-naïve advanced adenocarcinoma patients were recruited in seven Formalin-fixed...
To identify a cyclical pattern in short-term postoperative outcomes after colorectal cancer (CRC) surgery across the year. Observational study including all consecutive patients diagnosed with CRC who underwent oncological between January 2012 and December 2023. A time series was performed to possible cyclic of complications. Non-supervised learning techniques were used months similar outcome variables series. Multivariable analysis logistic binary regression conducted independent risk...
Abstract Background Chromosomal instability (CIN) is involved in about 70% of colorectal cancers (CRCs) and associated with poor prognosis drug resistance. From a clinical perspective, better knowledge these tumour’s biology will help to guide therapeutic strategies more effectively. Methods We used high-density chromosomal microarray analysis evaluate CIN level patient-derived organoids (PDOs) their original mCRC tissues. integrated the RNA-seq mass spectrometry-based proteomics data from...
Gastric cancer (GC) is recognized for intrinsic heterogeneity, although it similarly approached in Europe and Latin America (LATAM). The LEGACY project aimed to deepen GC molecular understanding through multi-omics analysis LATAM samples. Tumor samples were centrally reviewed histology, human epidermal growth factor receptor 2 (HER2) expression, mismatch repair-deficient (dMMR)/microsatellite instability (MSI) status. In addition, we assessed Epstein-Barr virus (EBV) status, programmed...
This study aimed to develop a prognostic model for colorectal cancer (CRC) patients using biomarkers from routine preoperative peripheral blood examinations combined with clinical factors. observational comprised CRC (stages I-III) who underwent curative surgery between January 2011 and December 2019. Study variables included patient demographics, tumour characteristics, immune/inflammatory markers tests. Cut-off thresholds continuous were determined maximally selected rank statistics....
ABSTRACT Introduction Current guidelines do not mandate CD19 tumor expression assessment before chimeric antigen receptor T‐cell (CAR‐T) therapy in large B‐cell lymphoma (LBCL) patients due to limitations of immunohistochemistry (IHC) or flow cytometry. Quantitative polymerase chain reaction (qPCR) offers a more sensitive alternative for detecting expression, with the primary advantage that mRNA can be easily extracted from paraffin‐embedded tissues. Methods & Results In our study, we...
Abstract Background Gastric cancer (GC) patients from European (EU) and especially Latin American (LATAM) countries are underrepresented in previous large-scale multi-omic studies that have identified clinically relevant subgroups. The LEGACY study aimed to profile the molecular immunological features of GCs EU LATAM countries. Methods Tumor biopsies 95 56 were profiled with immunohistochemistry (CD3, CD8, FOXP3, PD-L1, MSI HER2), Nanostring mRNA expression analyses, microbiome sequencing....
While only 15-25 percent of melanoma patients develop distant metastasis and die, this disease is still responsible for the majority skin cancer-related deaths. The availability adjuvant therapies makes selection high-risk essential. We evaluated intratumoral expression ten miRNAs in primary melanomas relation to its ability predict survival. To end, we correlated miRNA 132 cryopreserved metastatic tumors with clinicopathological factors clinical outcome. found sequential downregulation...
BackgroundColon cancer (CC) is a heterogeneous disease. Novel prognostic factors beyond pathological staging are required to accurately identify patients at higher risk of relapse. Integrating these new biological factors, such as plasma circulating tumour DNA (ctDNA), CDX2 staining, inflammation-associated cytokines and transcriptomic consensus molecular subtypes (CMS) classification, into multimodal approach may improve our accuracy in determining recurrence.MethodsOne hundred fifty...
Colitis-associated colorectal carcinoma (CAC) occurs in inflammatory bowel disease (IBD) because of the “chronic inflammation-dysplasia-cancer” carcinogenesis pathway characterized by p53 alterations early stages. Recently, gastric metaplasia (GM) has been described as initial event serrated cancer (CRC) process, resulting from chronic stress on colon mucosa. The aim study is to characterize CAC analyzing and microsatellite instability (MSI) explore their relationship with GM using a series...