A5008132324- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Autoimmune Bullous Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Autoimmune and Inflammatory Disorders
- Genetic and rare skin diseases.
- Vascular Tumors and Angiosarcomas
- Histiocytic Disorders and Treatments
- Polyomavirus and related diseases
- Skin Diseases and Diabetes
- Eosinophilic Disorders and Syndromes
- Dermatological and Skeletal Disorders
- Melanoma and MAPK Pathways
- Dermatological and COVID-19 studies
- Soft tissue tumor case studies
- Tumors and Oncological Cases
- Antenna Design and Analysis
- Full-Duplex Wireless Communications
- Sarcoma Diagnosis and Treatment
- Dermatologic Treatments and Research
- Skin and Cellular Biology Research
- Oral Health Pathology and Treatment
- Infectious Diseases and Mycology
- Lymphoma Diagnosis and Treatment
Hospital General de Catalunya
2017-2025
Universitat Internacional de Catalunya
2018-2025
Hospital Universitari Sagrat Cor
2018-2024
Hospital Quirónsalud Barcelona
2017-2024
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Oxfam
2023
Hudson Institute
2023
John Wiley & Sons (United Kingdom)
2023
Hospital Universitari Germans Trias i Pujol
2012-2021
Merkel cell polyomavirus (MCV) is a recently discovered human virus closely related to African green monkey lymphotropic polyomavirus. MCV DNA integrated in approximately 80% of carcinomas (MCC), neuroendocrine skin cancer linked lymphoid malignancies such as chronic lymphocytic leukemia (CLL). To assess infection and its association with diseases, we developed monoclonal antibody that specifically recognizes endogenous transfected large T (LT) antigen. We show expression LT protein...
Abstract Background Progression from actinic keratosis (AK) to invasive squamous cell carcinoma ( iSCC ) of the skin is thought occur after development full thickness epidermal neoplasia, as in classic pathway cervical cancer. Nevertheless, cutaneous may also directly arise a proliferation atypical basaloid cells limited mostly basal layer (AK I), akin what happens ‘differentiated pathway’ vulva, oral cavity and other locations. Objective To evaluate prevalence differentiated pathways ....
BackgroundMultiple studies have compared the performance of artificial intelligence (AI)–based models for automated skin cancer classification to human experts, thus setting cornerstone a successful translation AI-based tools into clinicopathological practice.ObjectiveThe objective study was systematically analyse current state research on reader involving melanoma and assess their potential clinical relevance by evaluating three main aspects: test set characteristics...
Mice lacking desmin produce muscle fibers with Z disks and normal sarcomeric organization. However, the muscles are mechanically fragile degenerate upon repeated contractions. We report here a human patient severe generalized myopathy aberrant intrasarcoplasmic accumulation of intermediate filaments. Muscle tissue from this lacks wild-type allele has gene mutation encoding 7-aa deletion within coiled-coil segment protein. show that recombinant harboring cannot form proper filament networks...
Insulin-dependent diabetes mellitus (IDDM), in which only the pancreatic beta cells are destroyed by autoimmune response, is paradigm of organ-specific autoimmunity. As a result combination factors, number immunohistologic/cellular/molecular studies pancreas IDDM very limited. We report here conducted pancreata two patients: one newly diagnosed (case 1) and long standing 2). In case 1, we demonstrated presence morphologically normal viable without evidence viral infection. both cases...
The vacuoles, E1-enzyme, X linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset disease (AID) due to postzygotic UBA1 variants.To investigate the presence of VEXAS among patients with undiagnosed AID. Additional studies evaluated mosaicism distribution circulating cytokines.Gene analyses were performed by both Sanger amplicon-based deep sequencing. Patients' data collected from their medical charts. Cytokines quantified Luminex.Genetic enrolled (n=42) identified 30...
Accurate melanoma diagnosis is crucial for patient outcomes and reliability of AI diagnostic tools. We assess interrater variability among eight expert pathologists reviewing histopathological images clinical metadata 792 melanoma-suspicious lesions prospectively collected at German hospitals. Moreover, we provide access to the largest panel-validated dataset featuring dermoscopic with metadata. Complete agreement achieved in 53.5% cases (424/792), a majority vote ( ≥ five pathologists)...
The amplitude death phenomenon has been experimentally observed with a pair of thermo-optical oscillators linearly coupled by heat transfer. A parametric analysis done and compared numerical simulations time delayed model. role the coupling strength is also discussed from experimental results.
ABSTRACT Dendritic cells (DCs) are specialized antigen-presenting cells. However, DCs exposed to human immunodeficiency virus type 1 (HIV-1) also able transmit a vigorous cytopathic infection CD4 + T cells, process that has been frequently related the ability of DC-SIGN bind HIV-1 envelope glycoproteins. The maturation can increase efficiency transmission through trans infection. We aimed comparatively study effect in monocyte-derived (MDDCs) and blood-derived myeloid during capture process....
Myeloid cells are key players in the recognition and response of host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid might also promote viral pathogenesis through trans-infection, a mechanism that promotes transmission to target via capture storage. The receptor Siglec-1 (CD169) potently enhances trans-infection is regulated by immune activating signals present throughout course such as interferon α (IFNα). Here we show IFNα-activated dendritic cells, monocytes...
New targeted therapies for cancer have been released in recent years, opening new horizons the treatment of patients with cancer. However, their related adverse events (AE) are not fully characterized. Hair repigmentation (HR) is a nondescribed effect secondary to anti-programmed cell death 1 (anti-PD-1) and ligand (anti-PD-L1 ) therapy lung (LC), opposition vitiligo reactions that develop during melanoma treatment.To describe event occurring anti-PD-1/anti-PD-L1 LC.A case series from...
Background: Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology in which skin involvement frequent. Objective: To review histological characteristics biopsies specific cutaneous lesions sarcoidosis and their relationship with clinical course. Patients methods: Biopsies from 32 patients were reviewed. Histological findings these analysed. Results: The initial the ten infiltrated nodule‐plaques, eight papules, four maculopapular eruptions, five scar sarcoidosis,...
Cell-to-cell virus transmission is one of the most efficient mechanisms human immunodeficiency (HIV) spread, requires CD4 and coreceptor expression in target cells, may also lead to syncytium formation cell death. Here, we show that addition this classical coreceptor-mediated transmission, contact between HIV-producing cells primary T lacking appropriate induced uptake HIV particles by absence membrane fusion or productive replication. required cellular contacts mediated binding gp120 intact...
Objective: Compared with cell-free viral infection, virological synapses increase HIV capture by target cells, infectivity and cytopathicity, are believed to be less sensitive antibody neutralization. We have evaluated the impact of antibodies against envelope glycoproteins (gp120 gp41) on cell-to-cell transmission. Methods: analyzed role trogocytosis in transmission inhibitory mechanisms antigp120 IgGb12 antigp41 4E10 2F5 using cocultures NL4-3 or BaL-infected MOLT/CCR5 cells primary CD4 T...