A5069986166- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- NF-κB Signaling Pathways
- Herpesvirus Infections and Treatments
- T-cell and Retrovirus Studies
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- interferon and immune responses
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Immune Response and Inflammation
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
USC Norris Comprehensive Cancer Center
2021-2025
University of Southern California
2015-2024
Keck Hospital of USC
2020-2021
University of Louisiana at Lafayette
2012
UPMC Hillman Cancer Center
2005-2011
University of Pittsburgh
2005-2010
Palmetto Hematology Oncology
2010
The University of Texas Southwestern Medical Center
1999-2007
Southwestern Medical Center
1999-2007
University of Pittsburgh Medical Center
2007
Merkel cell polyomavirus (MCV) is a recently discovered human virus closely related to African green monkey lymphotropic polyomavirus. MCV DNA integrated in approximately 80% of carcinomas (MCC), neuroendocrine skin cancer linked lymphoid malignancies such as chronic lymphocytic leukemia (CLL). To assess infection and its association with diseases, we developed monoclonal antibody that specifically recognizes endogenous transfected large T (LT) antigen. We show expression LT protein...
Abstract We have cloned a TNFR family member from follicular dendritic cell (FDC)-like line, FDC-1. This molecule, FDC-derived receptor-1 (FDCR-1), is identical to osteoprotegerin (OPG), soluble cytokine that regulates osteoclast differentiation. Recently, OPG/FDCR-1 has been characterized as second receptor for activator of NF-κB ligand (RANKL)/TNF-related activation-induced (TRANCE), primarily T-cell restricted TNF augments (DC) function. In this report, we demonstrate membrane bound on...
The human herpesvirus 8 (HHV8, also called Kaposi's sarcoma-associated herpesvirus) has been linked to sarcoma and primary effusion lymphoma (PEL) in immunocompromised individuals. We demonstrate that PEL cell lines have a constitutively active NF-κB pathway, which is associated with persistent phosphorylation of IκBα. To elucidate the mechanism activation lines, we investigated role viral FLICE inhibitory protein (vFLIP) this process. report stable expression HHV8 vFLIP variety caused by...
Activation of the cascade proteolytic caspases has been identified as final common pathway apoptosis in diverse biological systems. We have isolated a gene, termed MRIT , that possesses overall sequence homology to FLICE (MACH), large prodomain caspase links aggregated complex death domain receptors tumor necrosis factor receptor family downstream caspases. However, unlike FLICE, C-terminal lacks catalytic consensus QAC(R/Q)G. Nonetheless activates caspase-dependent death. Using yeast...
The Kaposi's sarcoma-associated herpesvirus (KSHV, also called human 8) has been linked to KS and primary effusion lymphoma (PEL) in immunocompromised individuals. We report that PEL cell lines have constitutive active alternative NF-κB pathway demonstrate high-level expression of NF-κB2/p100 precursor its processed subunit p52. To elucidate the mechanism activation cells, we investigated role KSHV-encoded viral Fas-associated death domain-like IL-1β-converting enzyme inhibitory protein...
The DiseaseConnect (http://disease-connect.org) is a web server for analysis and visualization of comprehensive knowledge on mechanism-based disease connectivity. traditional classification system groups diseases with similar clinical symptoms phenotypic traits. Thus, entirely different pathologies could be grouped together, leading to treatment design. Such problems avoided if were classified based their molecular mechanisms. Connecting pathological mechanisms inspire novel strategies the...
COVID-19, caused by SARS-CoV-2, continues to be a major health problem since its first description in Wuhan, China, December 2019. Multiple drugs have been tried date the treatment of COVID-19. Critical COVID-19 and advancing therapeutics is an appreciation multiple stages this disease importance timing for investigation use various agents. We considered articles related indexed on PubMed published January 1, 2020-November 15, 2020, papers medRxiv preprint server. identified relevant...
The ectodermal dysplasia receptor (EDAR) is a recently isolated member of the tumor necrosis factor family that has been shown to play key role in process differentiation. We present evidence EDAR capable activating nuclear factor-kappaB, JNK, and caspase-independent cell death pathways these activities are impaired mutants lacking its domain or those associated with anhidrotic downless phenotype. Although possesses domain, it did not interact domain-containing adaptor proteins TRADD FADD....
Caspase-8 (CASP8) is an apoptosis inducing cysteine protease which activated through the formation of a death-inducing signaling complex when death receptors are complexed to their specific ligands. Recent reports indicate that CASP8 expression lost via combination promoter methylation and allelic loss in subset neuroblastomas. We investigated state gene lung tumors cell lines. RT-PCR studies indicated was most (27 34, 79%) small carcinoma (SCLC) lines, but retained all 22 non-SCLC (NSCLC)...
Abstract TNF‐related apoptosis‐inducing ligand (TRAIL) selectively induces programmed cell death (apoptosis) in various cancer cells but not normal cells. TRAIL is known to bind 4 different receptors, 2 proapoptotic ( DR4 and DR5 ), potentially antiapoptotic receptors lacking domains DcR1 DcR2 ). Aberrant promoter methylation resultant silencing of tumor suppressor genes play an important role the pathogenesis many types. Recently aberrant decoy was reported pediatric lines neuroblastomas....
Endothelial cells play a pivotal role in the inflammatory process by coordinating recruitment of to sites tissue injury. Lipopolysaccharide (LPS) activates many proinflammatory and procoagulant responses endothelial cells, injury is thought crucial pathogenesis septic shock due Gram-negative bacteria. The receptor used LPS signal has not been identified. It also known how induces injury/death. In this study, we demonstrate that mediates apoptosis FADD-dependent pathway. FADD death...
We have isolated a novel member of the TNFR family, designated TAJ, that is highly expressed during embryonic development. TAJ possesses unique cytoplasmic domain with no sequence homology to previously characterized members family. interacts TRAF family and activates JNK pathway when overexpressed in mammalian cells. Although it lacks death domain, capable inducing apoptosis by caspase-independent mechanism. Based on its expression profile signaling properties, may play an essential role
Propagation of signals from the T cell antigen receptor (TCR) involves a number adaptor molecules. SH2 domain–containing protein 76 (SLP-76) interacts with guanine nucleotide exchange factor Vav to activate nuclear activated cells (NF-AT), and its expression is required for normal development. We report cloning characterization novel Grb2-like molecule designated as Grb2-related lymphoid system (GrpL). Expression GrpL restricted hematopoietic tissues, it distinguished Grb2 by having...