A5017878103- Microwave Engineering and Waveguides
- Antenna Design and Analysis
- Fungal and yeast genetics research
- Genomics and Chromatin Dynamics
- Advanced Antenna and Metasurface Technologies
- Endoplasmic Reticulum Stress and Disease
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- Electromagnetic Compatibility and Noise Suppression
- Microwave and Dielectric Measurement Techniques
- Protein Degradation and Inhibitors
- Crystallography and molecular interactions
- DNA Repair Mechanisms
- Radio Frequency Integrated Circuit Design
- Insect Resistance and Genetics
- Histone Deacetylase Inhibitors Research
- Hand Gesture Recognition Systems
- RNA Research and Splicing
- Advanced Power Amplifier Design
- RNA regulation and disease
- Beetle Biology and Toxicology Studies
- Heat shock proteins research
- Trace Elements in Health
- Semiconductor Lasers and Optical Devices
Indian Institute of Science Education and Research, Bhopal
2016-2025
LNM Institute of Information Technology
2008-2024
Central Electronics Engineering Research Institute
2011-2024
University of Delhi
2013-2024
Bhopal Memorial Hospital & Research Centre
2016
Indian Institute of Science Bangalore
2014
Florida State University
2013
Council of Scientific and Industrial Research
2011
Pennsylvania State University
2007-2009
Indian Institute of Technology Kanpur
1983-2005
Ebselen is a synthetic, lipid‐soluble seleno‐organic compound. The high electrophilicity of ebselen enables it to react with multiple cysteine residues various proteins. Despite extensive research on ebselen, its target molecules and mechanism action remains less understood. We performed biochemical as well in vivo experiments employing budding yeast model organism understand the mode ebselen. growth curve analysis FACS (florescence activated cell sorting) assays revealed that exerts...
DNA microarray and genetic studies of Saccharomyces cerevisiae have demonstrated that histone deacetylases (HDACs) are required for transcriptional activation repression, but the mechanism by which they activate transcription remains poorly understood. We show two HDACs, RPD3 HOS2, damage-inducible genes RNR3 HUG1. Using mutants specific Rpd3L complex, we complex is responsible regulating RNR3. Furthermore, unlike what was described GAL genes, regulates deacetylating nucleosomes at promoter,...
Benzamide ring-substituted, quinine-derived ebselen analogue is synthesized which exists in selenol form upon addition of PhSH. It catalyses oxidation PhSH with H<sub>2</sub>O<sub>2</sub> faster (10<sup>3</sup>-fold) than ebselen.
The translocation of proteins from the cytoplasm to endoplasmic reticulum occurs via a conserved Sec61 protein channel. Previously, we reported that mutations in histones cause downregulation CUP1 copper metallothionein and exposure inhibits activity Sec61. However, role epigenetic dysregulation on channel is not clear. Identification cellular factors regulating metabolism needed as can human diseases. In this study, elucidate intricate relationship between homeostasis Sec61-mediated...
Abstract —This paper presents an optimized design for&#xD; conventional non-field plate and field AlN/β-Ga2O3&#xD; metal oxide semiconductor high electron mobility transis&#xD;tor (MOSHEMT). The transparent β-Ga2O3 with ultra wide&#xD; bandgap, is crucial to enhance the performance efficiency of&#xD; proposed device design. This property positions it as a strong&#xD; contender replace GaN SiC in power applications.&#xD; A comparative analysis of AlN/β-Ga2O3...
ABSTRACT Yeast flocculation relies on cell surface flocculin proteins encoded by the sub‐telomeric gene, FLO1 . The expression of is antagonistically regulated Tup1‐Cyc8 repressor complex and Swi‐Snf co‐activator complexes. role hyperacetylated N‐terminal amino acid residues histone H3 H4 well established in transcription other genes. However, sub‐domains within tails are yet to be identified mechanism which they regulate completely unexplored. Upon screening different stretch deletion...
Abstract A versatile fluorescent probe, PITE, based on alkyl‐substituted pyridoindole (PI) and tetraphenylethylene (TE), which exhibits facile pH‐induced fluorescence switching in solution, as nanoparticles, the solid state, is presented. Strong well solution aggregated allow sensing of toxic acid vapors. Fluorescence “off–on” PITE through exposure to trifluoroacetic triethylamine vapor visualized by naked eye. unified picture switchable obtained comprehensive spectroscopic investigations...
Abstract A new type of fractal‐shaped microstrip patch antenna for ultra‐wideband (UWB) applications and with sufficient rejection in the WLAN band is presented. The radiating placed on a 1.6 mm thick low‐cost FR‐4 epoxy substrate fed using symmetric coplanar waveguide. size proposed terms wavelength 0.189 λ 0 × 0.197 . sectorial‐circular slot used to create notch. An impedance bandwidth 11.76 GHz (from 2.19 13.95 GHz) achieved, along achieving from 4.67 6.21 GHz. Nearly omnidirectional...
Clipping of histone tails has been reported in several organisms. However, the significance and regulation tail clipping largely remains unclear. According to recent discoveries H3 found be involved gene expression chromatin dynamics. Earlier we had provided evidence tissue-specific proteolytic processing White Leghorn chicken liver nuclei. In this study identify a novel activity glutamate dehydrogenase (GDH) as H3-specific protease tissue. This is regulated by divalent ions thiol-disulfide...
Mutations in the Senataxin gene, SETX are known to cause neurodegenerative disorders, ataxia with oculomotor apraxia type 2 (AOA2), and amyotrophic lateral sclerosis 4 (ALS4). However, mechanism underlying disease pathogenesis is still unclear. The N-terminal protein-interaction C-terminal RNA/DNA helicase domains conserved Saccharomyces cerevisiae homolog, Sen1p. Using genome-wide expression analysis, we first show alterations key cellular pathways such as: redox, unfolded protein response,...
Four coordination compounds of formulae [Cu(II)2(H2L(1))(HL(1))](ClO4)3·H2O (1), [Cu(II)2(H2L(2))(CH3OH)2](ClO4)2·2CH3OH (2), [Co(II)2(H2L(1))2](ClO4)4 (3) and [Co(II)2(H2L(2))2]·2H2O (4) were synthesized via self-assembly succinohydrazone derived ligands (H2L(1) = N',N'-4-bis(2-pyridyl)succinohydrazide, H4L(2) N',N'-4-bis(2-hydroxybenzylidene)succinohydrazide) Cu(2+) Co(2+) ions, respectively. The characterized by crystal structure determination, magnetic measurements biological activities....
New quasi-static models for the computer-aided design (CAD) and analysis of open suspended inverted microstrip lines are reported. The obtained through generalizing those reported earlier applicable up to epsilon/sub r/= 20, thereby covering all practically used substrate materials these structures. also cover a larger range dimension ratios accurate within 0.6 percent 1 synthesis.
Until recently, microstrip filter designs were being done with full metallic ground-plane present on one side of the substrate. The state-of-the-art, however, changed when deliberately created defects in ground (called Defected Ground Structures or, simply, DGS) introduced, to further improve performance. This paper presents four original design examples low-pass and band-pass filters without DGS. Design methodology, optimization details, fabrication experimentally-obtained data are...
Curcumin, a naturally occurring polyphenolic compound, is known to possess diverse pharmacological properties. There scarcity of literature documenting the exact mechanism by which curcumin modulates its biological effects. In present study, we have used yeast as model organism dissect underlying action curcumin. We found that mutants histone proteins and chromatin modifying enzymes were sensitive further supplementation iron resulted in reversal changes induced Additionally, treatment...