A5002551163- Acute Myeloid Leukemia Research
- Sphingolipid Metabolism and Signaling
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- DNA Repair Mechanisms
- Fungal and yeast genetics research
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Selenium in Biological Systems
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Crystallography and molecular interactions
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Trace Elements in Health
- Natural Antidiabetic Agents Studies
- Endoplasmic Reticulum Stress and Disease
- Genomics and Chromatin Dynamics
- Chronic Myeloid Leukemia Treatments
- RNA regulation and disease
- Curcumin's Biomedical Applications
Pennsylvania State University
2018-2024
Penn State Milton S. Hershey Medical Center
2020-2024
Kanya Maha Vidyalaya
2022
University of Lucknow
2022
Cancer Institute (WIA)
2021
Indian Institute of Science Education and Research, Bhopal
2013-2018
Bhopal Memorial Hospital & Research Centre
2016
Indian Institute of Science Bangalore
2014
Chaitanya Bharathi Institute of Technology
2014
Florida State University
2013
Ebselen is a synthetic, lipid‐soluble seleno‐organic compound. The high electrophilicity of ebselen enables it to react with multiple cysteine residues various proteins. Despite extensive research on ebselen, its target molecules and mechanism action remains less understood. We performed biochemical as well in vivo experiments employing budding yeast model organism understand the mode ebselen. growth curve analysis FACS (florescence activated cell sorting) assays revealed that exerts...
Desmostachya bipinnata Stapf (Poaceae/Gramineae) is an official drug of ayurvedic pharmacopoeia. Various parts this plant were used extensively in traditional and folklore medicine to cure various human ailments. The present study was aimed evaluate the antioxidant DNA damage protection activity hydroalcoholic extract both vitro vivo , provide scientific basis for usage plant. showed significant a dose-dependent manner with IC 50 value of<mml:math...
study (supplemental Table 11, Column D) are subject to restrictions set by the ORIEN network, and access is controlled M2Gen consortium.Requests these datasets should be directed https://www.oriencancer.org/request-an-account.
Secondary acute myeloid leukemia (sAML) is a heterogeneous malignant hematopoietic disease that arises either from an antecedent hematologic disorder (AHD) including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), aplastic anemia (AA), or as result of exposure to genotoxic chemotherapeutic agents radiotherapy (therapy related AML, tAML). sAML diagnosed when the number blasts &ge;20% in bone marrow peripheral blood, and it characterized by poor prognosis, resistance...
The clinical signs of multiple myeloma, a plasma cell (PC) dyscrasia, include bone loss, renal damage, and paraproteinemia. It can be defined as the uncontrolled growth malignant PCs within marrow. distinctive marrow milieu that regulates progression myeloma disease involves interactions between stromal cells, myeloid lymphoid cells. These cells affect immune system independently or because complicated web interconnections, which promotes development evasion. Due to importance these factors...
Mutations in the Senataxin gene, SETX are known to cause neurodegenerative disorders, ataxia with oculomotor apraxia type 2 (AOA2), and amyotrophic lateral sclerosis 4 (ALS4). However, mechanism underlying disease pathogenesis is still unclear. The N-terminal protein-interaction C-terminal RNA/DNA helicase domains conserved Saccharomyces cerevisiae homolog, Sen1p. Using genome-wide expression analysis, we first show alterations key cellular pathways such as: redox, unfolded protein response,...
Four coordination compounds of formulae [Cu(II)2(H2L(1))(HL(1))](ClO4)3·H2O (1), [Cu(II)2(H2L(2))(CH3OH)2](ClO4)2·2CH3OH (2), [Co(II)2(H2L(1))2](ClO4)4 (3) and [Co(II)2(H2L(2))2]·2H2O (4) were synthesized via self-assembly succinohydrazone derived ligands (H2L(1) = N',N'-4-bis(2-pyridyl)succinohydrazide, H4L(2) N',N'-4-bis(2-hydroxybenzylidene)succinohydrazide) Cu(2+) Co(2+) ions, respectively. The characterized by crystal structure determination, magnetic measurements biological activities....
Curcumin, a naturally occurring polyphenolic compound, is known to possess diverse pharmacological properties. There scarcity of literature documenting the exact mechanism by which curcumin modulates its biological effects. In present study, we have used yeast as model organism dissect underlying action curcumin. We found that mutants histone proteins and chromatin modifying enzymes were sensitive further supplementation iron resulted in reversal changes induced Additionally, treatment...
Allyl alcohol (AA) is one of the environmental pollutants used as a herbicide and industrial chemical. AA undergoes enzymatic oxidation in vivo to form Acrolein (Acr), highly reactive ubiquitous toxicant. The exposure AA/Acr has detrimental effects on cells fatal. In corroboration current literature describing toxicity, this study aimed investigate molecular cytotoxicity mechanisms using budding yeast eukaryotic model organism. Genome-wide transcriptome analysis treated with sublethal dose...
Abstract Valproic acid (VA) is a pharmacologically important histone deacetylase inhibitor that recently garnered attention as an anticancer agent. Since the molecular mechanisms behind multiple effects of VA are unclear, this study was aimed to unravel comprehensive cellular processes affected by and its targets in vivo using budding yeast model organism. Interestingly, genome-wide transcriptome analysis cells treated with showed differential regulation 30% genome. Functional enrichment...
Secondary acute myeloid leukemia (sAML) is a heterogeneous malignant hematopoietic disease that arises either from an antecedent hematologic disorder (AHD) including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), aplastic anemia (AA), or as result of exposure to genotoxic chemotherapeutic agents radiotherapy (therapy related AML, tAML). sAML diagnosed when the number blasts ≥20% in bone marrow peripheral blood, and it characterized by poor prognosis, resistance therapy...
Gene expression is a multi-step process which requires recruitment of several factors to promoters. One the factors, Sen1p an RNA/DNA helicase implicated in transcriptional termination and RNA processing yeast. In present study, we have identified novel function that regulates ribonucleotide reductase RNR1 gene, essential for maintaining genomic integrity. Cells with mutation domain or lacking N-terminal displayed drastic decrease basal level transcription gene showed enhanced sensitivity...
KP1019 ([trans-RuCl4(1H-indazole)2]; FFC14A) is one of the promising ruthenium-based anticancer drugs undergoing clinical trials. Despite pre-clinical and success KP1019, mode action various factors capable modulating its effects are largely unknown. Here, we used transcriptomics genetic screening approaches in budding yeast model deciphered targets plethora cellular pathways including signaling, metal homeostasis, vacuolar transport, lipid homeostasis that primarily targeted by KP1019. We...
Nutraceuticals are the food or a part of it that have some health beneficial effects with without nutritional values.For past several decades, these nutraceuticals been gaining importance as alternative supplemental medications along pharmaceuticals for prevention treatment wide-range diseases.These an attractive option over conventional therapies due to their less no side and values.Although effectiveness complementary has proven in Pre-/clinical trials, significant scientific debate is...
Despite several new therapeutic options for acute myeloid leukemia (AML), disease relapse remains a significant challenge. We have previously demonstrated that augmenting ceramides can counter various drug-resistance mechanisms, leading to enhanced cell death in cancer cells and extended survival animal models. Using nanoscale delivery system ceramide (ceramide nanoliposomes, CNL), we investigated the effect of CNL within standard care venetoclax/cytarabine (Ara-C) regimen. demonstrate...
Acute myelogenous leukemia (AML), the most prevalent acute and aggressive diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease. Because chemotherapy resistance is major obstacle to successful treatment, novel therapeutic intervention needed. Upregulated ceramide clearance via accelerated hydrolysis glycosylation has been shown be an element AML, problem considering crucial role plays eliciting apoptosis. Herein we employed agents that block determine if...
Essential oils (EOs) are defined as secondary metabolites of plants that volatile in nature and synthesized by various parts such buds, trichomes, bark, leaves, flowers, twigs, etc. They generally extracted through steam hydro distillation processes. The chemistry these essential is very complex mainly consists terpenes their oxygenated derivatives. color, aroma, volatility, lipophilicity some the salient features oils. Primarily, they used for flavoring purposes, but with advancement...
Chromatin regulates gene expression and genome maintenance, consists of histones other components. The post‐translational modification plays a key role in maintaining the structure function chromatin under different pathophysiological stress conditions. Here, we investigate functions previously unexplored amino acid residues H3 H4. To do so, screened library yeast histone mutants following DNA damage identified that substitution mutations (H3Q5A/E H3Q120A) H4 (H4Y88A/E H4R78K) render cells...