A5037474329- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Organoselenium and organotellurium chemistry
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer therapeutics and mechanisms
- Catalytic Cross-Coupling Reactions
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Advanced Synthetic Organic Chemistry
- Synthesis and pharmacology of benzodiazepine derivatives
- Alkaloids: synthesis and pharmacology
- Crystallography and molecular interactions
- Biochemical effects in animals
- Cholinesterase and Neurodegenerative Diseases
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Synthesis of heterocyclic compounds
- Innovative Microfluidic and Catalytic Techniques Innovation
- Organic Chemistry Cycloaddition Reactions
- Organometallic Compounds Synthesis and Characterization
- Organic and Inorganic Chemical Reactions
- Nanomaterials for catalytic reactions
- Synthesis and Biological Evaluation
Indian Institute of Science Education and Research, Bhopal
2010-2021
University of Delhi
2016
A transition-metal-free synthetic method has been developed for the synthesis of unsymmetrical diaryl chalcogenides (S, Se, and Te) from dichalcogenides arenes under oxidative conditions by using potassium persulfate at room temperature. Variously substituted such as anisole, thioanisole, diphenyl ether, phenol, naphthol, di- trimethoxy benzenes, xylene, mesitylene, N,N-dimethylaniline, bromine-substituted arenes, naphthalene, underwent carbon–chalcogen bond-forming reaction to give in...
Synthesis of substituted phenanthridinones and dibenzoazepinones has been realized from 2-halo-benzamides in the presence potassium tert-butoxide a catalytic amount 1,10-phenanthroline or AIBN. This new carbon–carbon bond forming reaction gives direct access to various biaryl lactams containing six- seven-membered rings chemoselectively. Carbon–carbon coupling seems proceed by generation radical amide ring which leads C–H arylation aniline.
An efficient copper-catalyzed method for the synthesis of biologically important ebselen and related analogues containing a Se−N bond has been developed. This is first report catalytic process selenation formation reaction. Copper-catalyzed reaction tolerates functional groups such as amides, hydroxyls, ethers, nitro, fluorides, chlorides. The best results are obtained by using combination potassium carbonate base, iodo- or bromo-arylamide substrates, selenium powder, copper iodide catalyst.
A new reaction for the synthesis of dimethylisoindolinones has been presented from 2-halo-N-isopropyl-N-alkylbenzamide substrates and KO(t)Bu by selective C-C coupling an unreactive tertiary sp(3) C-H bond. The manifested excellent selectivity toward a bond over primary or sec Moreover, biaryl along with alkyl-aryl can be achieved in one pot using dihalobenzamides 5-phenylisoindolin-1-ones. It seems that proceeds via radical pathway which aryl translocates 1,5-hydrogen atom transfer (HAT),...
Benzamide ring-substituted, quinine-derived ebselen analogue is synthesized which exists in selenol form upon addition of PhSH. It catalyses oxidation PhSH with H<sub>2</sub>O<sub>2</sub> faster (10<sup>3</sup>-fold) than ebselen.
The role of radical initiators AMVN and AIBN has been studied in the potassium tert-butoxide mediated biaryl coupling reaction aryl iodides with unactivated arenes. Radical initiator promoted carbon–carbon bond formation expeditiously from iodide having various groups such as amino, methoxy, fluoro, methyl, trifluoromethyl arenes presence (4 equiv.) at 110 °C 2–5 h. Substituted toluene, xylene, anisole, fluorobenzene also proceeded to form biaryls under AMVN-initiated conditions. Moreover...
Abstract The presence of a chalcogen atom at the ortho ‐position phenols enhances their radical chain‐breaking activity. Here, copper(I)‐catalyzed reaction 2,6‐dibromo‐ and 2,6‐diiodophenols with diorganodiselenides has been studied for introduction two organoselenium substituents both ‐positions phenolic antioxidants, which afforded 2,6‐diorganoseleno‐substituted in 80–92% yields having electron‐donating CH 3 , electron‐withdrawing CN CHO functionalities. Additionally, groups also novel...
Abstract 33 examples
Diaryl disulfides, sulfides and aryl alkyl were synthesized from isothiazolones.This method expedient high yielding procedure for diaryl under different reaction conditions.The structure of the compounds was determined with NMR, Mass Spectrometry Infrared Spectroscopy.
Abstract One‐pot Cu‐catalyzed reaction is applied to synthesize a series of organo Se—N heterocycles from readily available halo‐amides and selenium powder.
Abstract KOtBu In DMSO can be efficiently used for the synthesis of unsymmetrical diaryl sulfides and selenides from dichalcogenides aryl bromides.
Abstract In some cases the reaction with diphenyldisulfide affords dithiolated products [cf.