A5003812373- T-cell and Retrovirus Studies
- Blood Coagulation and Thrombosis Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Hemophilia Treatment and Research
- Viral-associated cancers and disorders
- Metabolism, Diabetes, and Cancer
- Silymarin and Mushroom Poisoning
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Phytochemicals and Antioxidant Activities
- Drug-Induced Hepatotoxicity and Protection
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Free Radicals and Antioxidants
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Bioactive Compounds and Antitumor Agents
- Ubiquitin and proteasome pathways
- bioluminescence and chemiluminescence research
- Platelet Disorders and Treatments
- 14-3-3 protein interactions
- Autoimmune and Inflammatory Disorders Research
- Protease and Inhibitor Mechanisms
- Natural product bioactivities and synthesis
- Ion Channels and Receptors
University of Illinois Chicago
2020-2025
Koneru Lakshmaiah Education Foundation
2024
Mount Sinai Medical Center
2024
University of Mississippi Medical Center
2011-2022
University of Southern California
2011-2021
University of Madras
2006-2019
Jackson Memorial Hospital
2015-2016
University of Mississippi
2015-2016
The University of Texas System
2014
The University of Texas Health Science Center at Tyler
2009-2012
AKT/PKB kinases transmit insulin and growth factor signals downstream of phosphatidylinositol 3-kinase (PI3K). AKT activation involves phosphorylation at two residues, Thr(308) Ser(473), mediated by PDK1 the mammalian target rapamycin complex 2 (mTORC2), respectively. Impaired is a key in metabolic disorders involving resistance, whereas hyperactivation linked to cancer pathogenesis. Here, we identify cytoplasmic NAD(+)-dependent deacetylase, Sirt2, as novel interactor, required for optimal...
Mutant p53 (mtp53) is an oncogene that drives cancer cell proliferation. Here we report mtp53 associates with the promoters of numerous nucleotide metabolism genes (NMG). Mtp53 knockdown reduces NMG expression and substantially depletes pools, which attenuates GTP-dependent protein activity invasion. Addition exogenous guanosine or GTP restores invasiveness cells, suggesting promotes invasion by increasing GTP. In addition, creates a dependency on nucleoside salvage pathway enzyme...
Abstract Hexokinase 2 (HK2), which catalyzes the first committed step in glucose metabolism, is induced cancer cells. HK2’s role tumorigenesis has been attributed to its kinase activity. Here, we describe a independent HK2 activity, contributes metastasis. binds and sequesters glycogen synthase 3 (GSK3) acts as scaffold forming ternary complex with regulatory subunit of protein A (PRKAR1a) GSK3β facilitate phosphorylation inhibition by PKA. Thus, functions an A-kinase anchoring (AKAP)....
Chemoprevention has emerged as a very effective preventive measure against carcinogenesis. Several bioactive compounds present in fruits and vegetables have revealed their cancer curative potential on benzo(a)pyrene (B(a)P) induced In the study, efficacy of quercetin level lipid peroxides, activities antioxidant enzymes tumor marker B(a)P experimental lung carcinogenesis Swiss albino mice was assessed. bearing animals there an increase weight, peroxidation such aryl hydrocarbon hydroxylase,...
Abstract Objectives: The aim of this study was to investigate mechanisms involved in the growth inhibitory effect silymarin, humanhepatocellular carcinoma. Materials and Methods: human hepatocellular carcinoma cell line HepG2 utilized MTT assay performed antiproliferative silymarin. Dual staining undertaken for ethidium bromide/acridine orange, propidium iodide DNA fragmentation studies were executed confirm presence apoptosis. Cell‐cycle analysis revealed by flow cytometry mitochondrial...
Abstract A simple, accurate, sensitive and robust assay that can rapidly specifically measure the death of target cells would have applications in many areas biomedicine particularly for development novel cellular- immune-therapeutics. In this study, we describe a cytotoxicity assay, termed Matador which takes advantage extreme brightness, stability glow-like characteristics recently discovered marine luciferases their engineered derivatives. The involves expression luciferase interest...
Highlights•AMPK activation is required to mitigate reactive oxygen species levels support metastasis•AMPK inhibits fatty acid synthesis (FAS) decrease NADPH consumption•AMPK supports oxidation (FAO) generate via malate conversion pyruvate•AMPK induces CD36 expression increase (FA) uptake and FAOSummaryAMPK's role in tumor initiation progression controversial. Here, we provide genetic evidence that AMPK for metastasis mouse models of breast cancer. In a model spontaneous cancer metastasis,...
Kaposi sarcoma-associated herpes virus (KSHV)-associated primary effusion lymphomas (PEL) have extremely poor prognosis when treated with conventional chemotherapy. KSHV-encoded viral FLICE-inhibitory protein (vFLIP) K13 binds to the IkappaB kinase (IKK) complex constitutively activate NF-κB pathway, which has been shown be essential for survival and proliferation of PEL cells. The molecular chaperone HSP90 is a component IKK required its activity.We analyzed effect inhibitors on cells...