A5077195454- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Trypanosoma species research and implications
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cytokine Signaling Pathways and Interactions
- Cardiac Fibrosis and Remodeling
- Systemic Lupus Erythematosus Research
- Pleural and Pulmonary Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
- Occupational and environmental lung diseases
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Vagus Nerve Stimulation Research
- Cardiovascular Disease and Adiposity
- Peptidase Inhibition and Analysis
University of Virginia
2018-2024
Pacific Dental College and Hospital
2024
University of Virginia Health System
2016-2024
Bristol-Myers Squibb (United States)
2023
Carter Center
2021
The University of Texas Health Science Center at Tyler
2007-2014
The University of Texas System
2008-2013
Central Drug Research Institute
2004-2007
The adaptive immune response plays an important role in atherosclerosis. In to a high-fat/high-cholesterol (HF/HC) diet, marginal zone B (MZB) cells activate atheroprotective programme by regulating the differentiation and accumulation of 'poorly differentiated' T follicular helper (Tfh) cells. On other hand, Tfh germinal centre response, which promotes atherosclerosis through production class-switched high-affinity antibodies. We therefore investigated direct IL18
Unstable human artery plaques can suddenly rupture, leading to MI or stroke. Identification of blood markers associated with unstable plaque features is clearly needed. Humans symptomatic carotid atherosclerotic have increased infiltration CD56bright Natural Killer (NK) cells, yet whether subjects coronary frequencies circulating NK cells unknown. Coronary intravascular ultrasound (IVUS) was performed on presenting for medically-indicated angiography. 18 stratified into high and low percent...
Local derangements of fibrin turnover and plasminogen activator inhibitor (PAI)-1 have been implicated in the pathogenesis pleural injury. However, their role control organization has unclear. We found that a C57Bl/6j mouse model carbon black/bleomycin (CBB) injury demonstrates resulting rind formation (14 d). In transgenic mice overexpressing human PAI-1, intrapleural deposition was increased, but visceral thickness, lung volumes, compliance were comparable to wild type. CBB PAI-1(-/-)...
SUMMARY In this study, cDNA microarray analysis of a closely related species, Leishmania major , was used as screening tool to compare antimonial-resistant and susceptible clinical isolates donovani in order identify candidate genes on the basis antimony resistance. Clinically confirmed resistant isolate 39 sensitive 2001 were study. Many differentially regulated identified whose expression levels differ sodium gluconate (SAG)-treated patients. Interestingly, array, showing changes over...
A number of earlier studies reported the occurrence thrombotic complications, particularly disseminated intravascular coagulation and deep vein thrombosis, in tuberculosis (TB) patients. The aberrant expression tissue factor (TF), primary activator cascade, is known to be responsible for disorders many diseases including bacterial infections. Further, TF by cells monocyte/macrophage lineage also shown contribute development progression local systemic inflammatory reactions. In present study,...
4-hydroxy-2-nonenal (HNE) is one of the major aldehydes formed during lipid peroxidation and believed to play a role in pathogenesis atherosclerosis. The objective present study investigate effect HNE on tissue factor (TF) procoagulant activity expressed cell surfaces.TF antigen levels intact cells were measured using Xa generation TF monoclonal antibody binding assays, respectively. Exposure phosphatidylserine surface was analyzed thrombin assay or by fluorescent dye-conjugated annexin V....
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Tuberculosis (TB) is a chronic lung infectious disease characterized by severe inflammation and granulomatous lesion formation. Clinical manifestations of TB include hypercoagulable states thrombotic complications. We previously showed that Mycobacterium tuberculosis (M.tb) infection induces tissue factor (TF) expression in macrophages vitro. TF plays key role coagulation inflammation. In the present study, we investigated M.tb-induced inflammatory responses, mycobacterial growth...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulator of FVIIa. However, in vitro showed AT inhibit FVIIa effectively only when it was bound to tissue factor (TF). Circulating blood is known contain traces TF, at best. also binds endothelial cell protein C receptor (EPCR), but the role EPCR on inactivation by unknown. The present study designed investigate TF and vivo. Low human mice (low ∼1% expression mouse level) high (HTF, ∼100% were...
The subtypes and markers of human immune cells with the greatest inflammatory response to IL-1β are identified.
Abstract Aims In light of recent data regarding inflammatory signalling pathways in cardiovascular disease and the recently demonstrated impact pharmacologic inhibition interleukin-1β (IL-1β) heart failure, primary aim was to assess physiologic effects cardiac resynchronization therapy (CRT) on expression systemic inflammatory, immune-modulatory, metabolic, apoptotic genes peripheral blood mononuclear cells (PBMCs) patients with failure. Methods results We used RNA sequencing (RNA-Seq)...