A5002322334- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- T-cell and B-cell Immunology
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Immune Cell Function and Interaction
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Acute Myocardial Infarction Research
- Chemokine receptors and signaling
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Sexual Differentiation and Disorders
- IL-33, ST2, and ILC Pathways
- Spatial Neglect and Hemispheric Dysfunction
- Single-cell and spatial transcriptomics
- TGF-β signaling in diseases
- Hormonal and reproductive studies
- Renal and Vascular Pathologies
- Diabetes and associated disorders
University of Virginia
2015-2024
Carter Center
2015-2024
Office of Public Health Genomics
2023
University of Virginia Health System
2005-2022
University of Virginia Medical Center
2022
Charlottesville Medical Research
2020-2022
Emory University
2022
Saint Luke's Hospital
2022
Ludwig-Maximilians-Universität München
2022
Beth Israel Deaconess Medical Center
2022
Visual object recognition was investigated in a group of eighty-one patients with right- or left-hemisphere lesions. Two tasks were used, one maximizing perceptual categorization by physical identity, the other semantic functional identity. The right-hemisphere showed impairment on task and impaired task. findings are discussed terms categorical stages recognition. A tentative model their cerebral organization is suggested.
The field of animal vocal communication has benefited greatly from improved understanding production mechanisms and specifically the generalization source–filter theory speech to non-human mammals. application enabled researchers decompose acoustic structure signals according their mode thereby predict variation that is caused by anatomical or physiological attributes caller. states result a two-stage production, with glottal wave generated in larynx (the source), being subsequently filtered...
Importance Drug-coated balloons offer a potentially beneficial treatment strategy for the management of coronary in-stent restenosis. However, none have been previously evaluated or approved use in circulation United States. Objective To evaluate whether paclitaxel-coated balloon is superior to an uncoated patients with restenosis undergoing percutaneous intervention. Design, Setting, and Participants AGENT IDE, multicenter randomized clinical trial, enrolled 600 (lesion length...
Objective- Three distinct human monocyte subsets have been identified based on the surface marker expression of CD14 and CD16. We hypothesized that monocytes were likely more heterogeneous in composition. Approach Results- used high dimensionality mass cytometry together with FlowSOM clustering algorithm to accurately identify define blood healthy subjects those coronary artery disease (CAD). To study behavior functionality newly defined subsets, we performed RNA sequencing, transwell...
Human monocyte subsets are defined as classical (CD14++CD16-), intermediate (CD14++CD16+), and nonclassical (CD14+CD16+). Alterations in subset frequencies associated with clinical outcomes, including cardiovascular disease, which circulating monocytes independently predict events. However, delineating mechanisms of function is hampered by inconsistent results among studies.We use cytometry time-of-flight mass to profile human using a panel 36 cell surface markers. Using the dimensionality...
Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here we show that atherogenesis Treg lose Foxp3 expression and their immunosuppressive function, leading conversion of a fraction these into follicular helper (Tfh) cells. We Tfh are pro-atherogenic depletion reduces atherosclerosis. Mechanistically, correlates with reduced IL-2Rα pSTAT5 levels increased IL-6Rα. In vitro, incubation naive oxLDL prevents differentiation Furthermore, injection...
Rationale: B cells contribute to atherosclerosis through subset-specific mechanisms. Whereas some controversy exists about the role of B-2 cells, B-1a are atheroprotective because secretion IgM antibodies independent antigen. B-1b a unique subset B-1 that respond specifically T-cell–independent antigens, have not been studied within context atherosclerosis. Objective: To determine whether produce and function protect against diet-induced Methods Results: We demonstrate sufficient...
Objective— Little is known about the role(s) B cells play in obesity-induced metabolic dysfunction. This study used a mouse with B-cell–specific deletion of Id3 (Id3 Bcell KO ) to identify B-cell functions involved consequences obesity. Approach and Results— Diet-induced obese mice demonstrated attenuated inflammation insulin resistance visceral adipose tissue (VAT), improved systemic glucose tolerance. VAT had increased B-1b elevated IgM natural antibodies oxidation-specific epitopes....
Preliminary semi-quantitative cardiovascular magnetic resonance (CMR) perfusion studies have demonstrated reduced myocardial reserve (MPR) in patients with angina and risk factors for microvascular disease (MVD), however fully quantitative CMR has not been studied. The purpose of this study is to evaluate whether identifies MPR population, investigate the relationship between epicardial atherosclerosis, left ventricular hypertrophy (LVH), extracellular volume (ECV), perfusion. Forty-six...
Objective— Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal)—the target allergen of delayed anaphylaxis red meat—is associated with disease. Approach Results— Total specific α-Gal were assayed on sera from 118 subjects who presented for cardiac catheterization underwent intravascular ultrasound. was detected in 26%, atheroma burden higher...
ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol accumulation and alters T cell homeostasis, which may contribute to progression of atherosclerosis. Here, we investigated how the selective loss ABCG1 in cells impacts atherosclerosis LDL receptor-deficient (LDLR-deficient) mice, a model disease. In LDLR-deficient mice fed high-cholesterol diet, cell-specific deficiency protected against atherosclerotic lesions. Furthermore, led 30% increase Treg percentages aorta...
Nonclassical monocytes (NCM) function to maintain vascular homeostasis by crawling or patrolling along the vessel wall. This subset of responds viruses, tumor cells, and other pathogens aid in protection host. In this study, we wished determine how early atherogenesis impacts NCM vasculature.To study role atherogenesis, quantified behaviors ApoE-/- (apolipoprotein E) C57BL/6J mice fed a Western diet. Using intravital imaging, found that from diet-fed display 4-fold increase activity within...
Rationale: B-1 cell-derived natural IgM antibodies against oxidation-specific epitopes on low-density lipoprotein are anti-inflammatory and atheroprotective. Bone marrow (BM) B-1a cells contribute abundantly to production, yet the unique repertoire of generated by BM factors maintaining population remain unexplored. CXCR4 (C-X-C motif chemokine receptor 4) has been implicated in human cardiovascular disease B-cell homeostasis, role cell regulating atheroprotective levels is unknown....
Abstract Background Increasing vasopressor dose is associated with increasing mortality in patients presenting acute myocardial infarction and cardiogenic shock (AMICS). It unknown whether the use of vasopressors independently harmful or if their secondary to decreasing intrinsic cardiac power output (CPO). Mechanical circulatory support (MCS) devices enhance CPO. We sought evaluate independent impact on survival National Cardiogenic Shock Initiative (NCSI). Methods The NCSI a single arm...
Circulating CD11c+ B cells, a novel subset of activated have been linked to autoimmunity and shown expand with age. Atherosclerosis is an age-associated disease that involves innate adaptive immune responses modified self-antigens. Yet, the expression CD11c on specific B-cell subtypes its link atherosclerosis are poorly understood. In this study, we characterized frequency cells in tissues mice aging. We observed increase spleen bone marrow ApoE −/− mice, was associated aortic plaque....
Catheter ablation of ventricular tachycardia (VT) can be limited by haemodynamic instability. In these cases, substrate-based is typically performed. An alternative to perform activation and entrainment mapping during VT supported a percutaneous left assist device (pVAD). We sought compare the complication success rates pVAD-assisted with scar-based techniques. Thirteen consecutive patients haemodynamically unstable underwent (pVAD group) were retrospectively compared 18-matched undergoing...
Adipose tissue surrounding major arteries (Perivascular adipose or PVAT) has long been thought to exist provide vessel support and insulation. Emerging evidence suggests that PVAT regulates artery physiology pathology, such as promoting atherosclerosis development through local production of inflammatory cytokines. Yet the immune subtypes in regulate inflammation are poorly characterized. B cells have emerged important regulation visceral atherosclerosis. cell-mediated effects on...