A5041316502- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Ultrasound and Hyperthermia Applications
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Hemodynamic Monitoring and Therapy
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Aortic aneurysm repair treatments
- Pericarditis and Cardiac Tamponade
- Kawasaki Disease and Coronary Complications
- Cardiomyopathy and Myosin Studies
University of Virginia Health System
2015-2024
University of Virginia
2014-2023
University Medical Centre Mannheim
2023
Heidelberg University
2023
Clinical Trial Investigators
2022
University of Virginia Medical Center
2001-2022
University of Michigan
2021
Neurological Surgery
2018
Barrow Neurological Institute
2018
Auckland City Hospital
2018
We hypothesized that successful reperfusion of an occluded infarct-related coronary artery even late after acute myocardial infarction would result in improved regional wall motion and such improvement might be related to the presence collateral blood flow within infarct bed.
BACKGROUND Although many patients with multivessel coronary artery disease (CAD) and severely depressed left ventricular (LV) function will benefit from bypass graft surgery (CABG), surgeons may be reluctant to perform CABG on these without evidence of myocardial viability in regions severe asynergy. We hypothesized that quantitative planar rest-redistribution 201Tl imaging would identify viable myocardium predict improved regional global after revascularization LV CAD. METHODS AND RESULTS...
Background Although residual myocardial viability in patients with coronary artery disease and extensive regional asynergy is associated improved ventricular function after bypass surgery, the relationship between clinical outcome surgery unclear. We hypothesized that poor predominantly viable myocardium have a better compared those less viability. Methods Results Seventy multivessel left ejection fractions <40% who underwent preoperative quantitative 201 Tl scintigraphy before were...
BACKGROUND Patency of the infarct-related artery (IRA) after acute myocardial infarction (AMI) may not reflect magnitude tissue perfusion. In animal models AMI, cellular necrosis has been associated with extensive capillary damage. Because contrast echocardiography (MCE) can define spatial distribution microvascular perfusion, we hypothesized that it could be used in patients recent AMI to distinguish regions have an intact microvasculature and thus are viable from those without viable....
Background —We hypothesized that coronary blood flow (CBF) reserve could be quantified noninvasively in humans using myocardial contrast echocardiography (MCE). Methods and Results —Eleven patients with normal epicardial arteries (group I) 19 single-vessel stenosis II) underwent quantitative angiography, MCE, CBF velocity measurements at rest during intravenous adenosine infusion. In group I patients, MCE-derived (MBF) (2.4±0.08) was similar to a Doppler wire (2.4±1.1). Patients single risk...
BACKGROUND We hypothesized that myocardial contrast echocardiography (MCE) can be used to both measure collateral blood flow as well assess the functional significance of collaterals in patients with acute infarction (AMI). METHODS AND RESULTS MCE was performed 33 recent AMI (12 +/- 7 days) and an occluded infarct-related artery (IRA), before after attempted percutaneous transluminal coronary angioplasty (PTCA). The size bed defined successful PTCA by injecting directly into opened IRA...
The American College of Cardiology Foundation (ACCF), Society for Cardiovascular Angiography and Interventions, Thoracic Surgeons, the Association Surgery, along with key specialty subspecialty societies, conducted an appropriateness review common clinical scenarios in which coronary revascularization is frequently considered. were developed to mimic situations encountered everyday practice included information on symptom status, extent medical therapy, risk level as assessed by noninvasive...
Abstract Objectives : The goal of this study was to determine the proportion patients with left main coronary disease (LMCD) unfavorable characteristics for percutaneous intervention (PCI). Background Published series suggest that LMCD can be treated percutaneously, however, in whom PCI is an option based on angiographic criteria unknown. Methods In 13,228 consecutive angiograms, 476 (3.6%) had ≤60% stenosis main. 232 unprotected LMCD, clinical and angiograms were reviewed six features...
The American College of Cardiology Foundation (ACCF), Society for Cardiovascular Angiography and Interventions, Thoracic Surgeons, the Association Surgery, along with key specialty subspecialty societies, conducted an update appropriate use criteria (AUC) coronary revascularization frequently considered. In initial document, 180 clinical scenarios were developed to mimic patient presentations encountered in everyday practice included information on symptom status, extent medical therapy,...
BACKGROUND Balloon angioplasty of atherosclerotic arteries results in activation the coagulation cascade. Several factors, including factor Xa and thrombin, are mitogenic for vascular smooth muscle cells vitro thus may play a role restenosis after balloon angioplasty. Specific inhibition can be achieved with recombinant antistasin (rATS) or tick anticoagulant peptide (rTAP). We hypothesized that would limit an rabbit model. METHODS AND RESULTS Focal femoral atherosclerosis was induced by air...